Patents by Inventor Alain Laurent
Alain Laurent has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20100221261Abstract: Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I or II or a salt thereof, in which R1, R2, R3, R100, R200, R300, A, A1, BG, Q and Q1 are substituents described herein. Also disclosed is the use of compounds of Formula I and II to treat proliferative disorders such as cancer.Type: ApplicationFiled: November 17, 2009Publication date: September 2, 2010Applicant: Aegera Therapeutics, Inc.Inventors: Alain Boudreault, James Jaquith, Patrick Bureau, John W. Gillard, Alain Laurent
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Publication number: 20100203012Abstract: Disclosed herein is a compound of Formula 1: or a salt thereof, in which R1, R1a, R100, R100a, R2, R200, R3, R300, A, A1, Q, Q1 and BG are as defined herein. Also disclosed is the use of the compounds of Formula 1 to treat disorders of dysregulated apoptosis, such as cancer and cellular proliferative disorders.Type: ApplicationFiled: May 30, 2008Publication date: August 12, 2010Applicant: Aegera Therapeutics, Inc.Inventors: Alain Laurent, Patrick Bureau, James Jaquith, John Gillard, Yannick Rose
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Patent number: 7772177Abstract: The present invention is directed towards an isomer, an enantiomer, a diastereoisomer, or a tautomer of a pyrrolidine compound represented by Formula I: in which the substituents R1, R1a, R2, R2a, R3, A and Q are defined herein; or a prodrug, or a salt thereof, and which bind to IAP BIR domains. In particular, the compounds are useful in treating proliferative disorders such as cancer.Type: GrantFiled: May 16, 2006Date of Patent: August 10, 2010Assignee: Aegera Therapeutics, Inc.Inventors: Scott Jarvis, Alain Boudreault, Patrick Bureau, James Jaquith, Alain Laurent, Delphine Labit
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Publication number: 20100145014Abstract: The present invention relates to an automated polymer synthesis apparatus for synthesizing a polymer chain onto a solid substrates by sequentially adding polymer building blocks as well as to a method for synthesizing polymers on solid substrates by sequentially reacting polymer building blocks with reactive groups. The invention further relates to a biochip comprising a solid substrate with reactive groups where biomolecules are attached to and the remaining reactive groups are transformed into chemically inert species.Type: ApplicationFiled: December 9, 2009Publication date: June 10, 2010Inventors: Alain LAURENT, Philippe Sarra-Bournet, Olivier Aude, Paul Morgavi, Bernard Mandrand, Marc Cuzin
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Publication number: 20100136538Abstract: The present invention relates to a labeling reagent of formula: in which: R1 represents at least one detectable label, L and A are each a linker arm, n is an integer equal to 1, and u is an integer between 0 and 2. The present invention also describes a method of synthesizing said markers and also applications for the labeling of biological molecules, more particularly nucleic acids, with a labeling reagent bearing diazo and nitro functions. The invention is particularly suitable for use in the diagnostics field.Type: ApplicationFiled: June 9, 2008Publication date: June 3, 2010Applicants: Biomerieux, CNRS, Universite De StrasbourgInventors: Alain Laurent, Ali Laayoun, Mitsuharu Kotera
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Publication number: 20100086976Abstract: The present invention concerns a method for decontaminating a solution of any nucleic acid present in said solution, comprising the following steps: for a sufficient period, subjecting the solution to the action of at least one type of molecule having the property of degrading the nucleic acids by fragmentation, termed a fragmentation molecule, until said nucleic acids, termed contaminating nucleic acids, have been completely degraded; and stopping the activity of the fragmentation molecule. The invention also concerns the use of said treated solution. The preferred application of the invention is in the field of diagnostics.Type: ApplicationFiled: March 28, 2008Publication date: April 8, 2010Applicant: BioMerieuxInventors: Glaucia Paranhos-Baccala, Alain Laurent, Ali Laayoun
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Patent number: 7645741Abstract: Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I or II or a salt thereof, in which R1, R2, R3, R100, R200, R300, A, A1, BG, Q and Q1 are substituents described herein. Also disclosed is the use of compounds of Formula I and II to treat proliferative disorders such as cancer.Type: GrantFiled: November 1, 2007Date of Patent: January 12, 2010Assignee: Aegera Therapeutics, Inc.Inventors: Alain Boudreault, James B. Jaquith, Patrick Bureau, John W. Gillard, Alain Laurent
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Publication number: 20090311688Abstract: The present invention relates to a labeled oligonucleotide comprising a first nucleotide segment and a second nucleotide segment, complementary to a target sequence, characterized in that it comprises a fluorophore, a quencher and at least one alpha-anomeric nucleoside. The invention also relates to the use of such an oligonucleotide and also to a process using such an oligonucleotide.Type: ApplicationFiled: September 26, 2007Publication date: December 17, 2009Applicant: BIOMERIEUXInventors: Eloy Bernal-Mendez, Ali Laayoun, Alain Laurent
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Patent number: 7589118Abstract: Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I: or a salt thereof, in which R1, R2, R100, R200, A, A1, B, B1, BG, n, Q and Q1 are substituents described. Also disclosed is the use of compounds of Formula 1 to treat proliferative disorders.Type: GrantFiled: October 20, 2006Date of Patent: September 15, 2009Assignee: Aegera Therapeutics, Inc.Inventors: Alain Laurent, Kim Hewitt, Stephen Morris
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Patent number: 7579320Abstract: Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I or II or a salt thereof, in which R1, R2, R3, R100, R200, R300, A, A1, BG, Q and Q1 are substituents described herein. Also disclosed is the use of compounds of Formula I and II to treat proliferative disorders such as cancer.Type: GrantFiled: March 16, 2007Date of Patent: August 25, 2009Assignee: Aegera Therapeutics, Inc.Inventors: Alain Boudreault, James B. Jaquith, Alain Laurent
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Publication number: 20090192140Abstract: Disclosed herein is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I: or a prodrug, or a pharmaceutically acceptable salt, or labeled with a detectable label or an affinity tag thereof; wherein R1, R1a, R100, R100a, R2, R200, W, B, and W1 are defined herein. Also disclosed are methods of using compounds of Formula I to treat proliferative disorders such as cancer.Type: ApplicationFiled: May 16, 2007Publication date: July 30, 2009Applicant: Aegera Therapeutics Inc.Inventors: Alain Laurent, Scott Jarvis, Patrick Bureau, Alain Boudreault, James Jaquith
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Patent number: 7566754Abstract: The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least one hydrophilic monomer having one ethylenically unsaturated double bond and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group. The crosslinkable copolymers of the invention are especially useful for the manufacture of biomedical mouldings, for example ophthalmic mouldings such as in particular contact lenses.Type: GrantFiled: August 10, 2007Date of Patent: July 28, 2009Assignee: Novartis AGInventors: Beat Müller, Alain Laurent, Veerle Coessens, Aaldert Rens Molenberg
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Patent number: 7547724Abstract: Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I: or a salt thereof, in which R1, R2, R100, R200, A, A1, B, B1, BG, n, Q and Q1 are substituents described. Also disclosed is the use of compounds of Formula 1 to treat proliferative disorders.Type: GrantFiled: December 1, 2006Date of Patent: June 16, 2009Assignee: Aegera Therpeutics, Inc.Inventors: Alain Laurent, Kim E. Hewitt, Stephen Morris, Patrick Bureau, Alain Boudreault, Scott Jarvis, James Jaquith
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Publication number: 20090117575Abstract: The present invention relates to a detection probe acting by molecular recognition of a target sequence, comprising successively in the 5?-3? direction: a first nucleotide segment comprising a sterically hindering structure at its 5? end, and a second nucleotide segment, complementary to the target sequence.Type: ApplicationFiled: April 23, 2007Publication date: May 7, 2009Applicant: BIOMERIEUXInventors: Eloy Bernal-Mendez, Ali Laayoun, Alain Laurent
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Patent number: 7446186Abstract: The invention relates to novel pyrrole derivatives of the formula (I) which make it possible to immobilize and address oligonucleotides by electropolymerization. Said invention also relates to thus produced electroactive polymers and to methods for using them for detecting, identifying and dosing analytes in a sample. (I) wherein R1 is one type of oligonucleotide, Y is S or O, X is a spacer arm selected from —(CH2)—O—, —(CH2)<SB>P</SB>O—[(CH2)2—O]q—, —(CH2)r; —CO—NR?—(CH2)r—O—, —CH2r—NCH3—(CH2)r—O—, —CH2)rCO—NR?—[CH2)2—O]s—, —(CH2)rNCH3[(CH2)2—O]<SB>S</SB>—, R? is H or CH3, n is an integer number ranging from 1 to 5, p is an integer number ranging from 1 to 2, q is an integer number ranging from 1 to 4, r is an integer number ranging from 1 to 3, r? is an integer number ranging from 1 to 3, s is an integer number ranging from 1 to 3, n, p, q, r, r? and s are identical or different, a pyrrole cycle is substituted in a position 2, 3, 4 or 5.Type: GrantFiled: December 16, 2003Date of Patent: November 4, 2008Assignee: BiomerieuxInventors: Bernard Mandrand, Daniela Zsoldos, Alain Laurent, Carole Chaix, Nicolas Spinelli
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Publication number: 20080021127Abstract: The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least one hydrophilic monomer having one ethylenically unsaturated double bond and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group. The crosslinkable copolymers of the invention are especially useful for the manufacture of biomedical mouldings, for example ophthalmic mouldings such as in particular contact lenses.Type: ApplicationFiled: August 10, 2007Publication date: January 24, 2008Inventors: Beat Muller, Alain Laurent, Veerle Coessens, Aaldert Molenberg
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Publication number: 20080014207Abstract: Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I: or a salt thereof, in which R1, R2, R100, R200, A, A1, B, B1, BG, n, Q and Q1 are substituents described. Also disclosed is the use of compounds of Formula 1 to treat proliferative disorders.Type: ApplicationFiled: December 1, 2006Publication date: January 17, 2008Applicant: AEGERA THERAPEUTICS, INC.Inventors: Alain Laurent, Kim Hewitt, Stephen Morris, Patrick Bureau, Alain Boudreault, Scott Jarvis, James Jaquith
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Publication number: 20070219140Abstract: Disclosed is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I: or a salt thereof, in which R1, R2, R100, R200, A, A1, B, B1, BG, n, Q and Q1 are substitutents described. Also disclosed is the use of compounds of Formula 1 to treat proliferative disorders.Type: ApplicationFiled: December 4, 2006Publication date: September 20, 2007Applicant: AEGERA THERAPEUTICS, INC.Inventors: Alain Laurent, Kim Hewitt, Stephen Morris, Patrick Bureau, Alain Boudreault, Scott Jarvis, James Jaquith
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Patent number: 7268189Abstract: The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least one hydrophilic monomer having one ethylenically unsaturated double bond and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group. The crosslinkable copolymers of the invention are especially useful for the manufacture of biomedical mouldings, for example ophthalmic mouldings such as in particular contact lenses.Type: GrantFiled: March 21, 2006Date of Patent: September 11, 2007Assignee: Novartis AGInventors: Beat Müller, Alain Laurent, Veerle Coessens, Aaldert Rens Molenberg
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Patent number: 7238750Abstract: The invention relates to novel crosslinkable copolymers which are obtainable by (a) copolymerizing at least one hydrophilic monomer having one ethylenically unsaturated double bond and at least one crosslinker comprising two or more ethylenically unsaturated double bonds in the presence of a chain transfer agent having a functional group; and (b) reacting one or more functional groups of the resulting copolymer with an organic compound having an ethylenically unsaturated group. The crosslinkable copolymers of the invention are especially useful for the manufacture of biomedical mouldings, for example ophthalmic mouldings such as in particular contact lenses.Type: GrantFiled: June 14, 2006Date of Patent: July 3, 2007Assignee: Novartis AGInventors: Beat Müller, Alain Laurent, Veerle Coessens, Aaldert Rens Molenberg