Abstract: A male element of a fluidic coupling intended to be coupled with a female element. The male element includes a ring, defining an annular space and in which ring radial housings are formed. Locking balls are received in the radial housings and are able to move radially between an inward position and an outward position. The balls are retained within their respective radial housings by narrowings having inner and outer projections provided where each respective radial housing meets the inner and outer faces of the ring. The ring has a first part and a second annular part, which parts are secured to one another. Longitudinal slots are provided in one of either the first or second parts of the ring.

Abstract: Drive mechanism configured for moving a wiper arm, the drive mechanism comprising a support assembly configured to cooperate with a wiper shaft extending according to a primary axis to allow a rotation of the wiper shaft with respect the support assembly according to the primary axis; a rotating assembly configured to be mounted in a rotationally fixed manner with the wiper shaft, the rotating assembly including at least one cylindrical bearing extending according to a secondary axis, the secondary axis being transverse to the primary axis; an inclination adjustment assembly including an inclination shaft configured to be fixed to the wiper arm and to cooperate with the at least one cylindrical bearing so as to be allowed to rotate according to the secondary axis, the inclination adjustment assembly further including a radial pin mounted on the inclination shaft and configured to cooperate with a biasing element of the support assembly.

Abstract: The invention relates to the field of personalized medicine, and the ability to administer targeted therapies consequently to biomarkers functional identification. In particular, the invention relates to the field of clinical applicable methods for the characterization, and especially the functional evaluation, of genetic variants in a patient. In particular, the invention relates to the field of the characterization, and classification, of variants of uncertain significance (VUS) or other unreported variants in patients. The in vitro method presented here is effective for the characterization of the functional impact of genetic variants in a patient, in particular of VUS, such as BRCA1 and BRCA2 VUS. The inventors have shown that this experimental framework can be used to obtain the necessary biological evidence of VUS function required for the prescription of targeted treatment within three weeks, which is compatible with use in clinical application.

Abstract: The present invention belongs to the field of improved personalized medicine. More precisely, the present invention relates to a method for progressively optimizing the 5-FU dose administered by continuous infusion in patients treated by a FOLFIRI regimen or a similar regimen, based on the 5-FU plasmatic concentration measured during the previous 5-FU continuous infusion and on a herein described decision algorithm. The present invention also relates to a method for treating a cancer patient in which the 5-FU dose administered in continuous infusion in each FOLFIRI or similar treatment cycle is optimized using the decision algorithm according to the invention.

Abstract: The present invention belongs to the field of improved personalized medicine. More precisely, the present invention relates to a method for progressively optimizing the 5-FU dose administered by continuous infusion in patients treated by a FOLFOX regimen or a similar regimen, based on the 5-FU plasmatic concentration measured during the previous 5-FU continuous infusion and on a herein described decision algorithm. The present invention also relates to a method for treating a cancer patient in which the 5-FU dose administered in continuous infusion in each FOLFOX or similar treatment cycle is optimized using the decision algorithm according to the invention.

Abstract: The present invention belongs to the field of improved personalized medicine. More precisely, the present invention relates to a method for progressively optimizing the 5-FU dose administered by continuous infusion in patients treated by a FOLFIRI regimen or a similar regimen, based on the 5-FU plasmatic concentration measured during the previous 5-FU continuous infusion and on a herein described decision algorithm. The present invention also relates to a method for treating a cancer patient in which the 5-FU dose administered in continuous infusion in each FOLFIRI or similar treatment cycle is optimized using the decision algorithm according to the invention.

Abstract: The invention relates to a method for controlling the homogeneity of the temperature of metallurgical products (B) in a reheating furnace (5) fitted with lateral burners. According to said method, the lateral burners are operated by on/off control, and the operating time and the down time of each burner is regulated in order to obtain the desired temperature. Inshot burners (1-4) are used as the lateral burners. Said burners are operated either at a speed which is close to the maximum speed or at the maximum speed, and the ignition order of the burners (1-4) is selected in such a way as to stimulate the stirring and circulation of the fumes in order to reduce the hot spot of the flame and to improve the homogeneity of the temperature of the walls of the furnace and the products.

Abstract: The invention relates to a method for controlling the homogeneity of the temperature of metallurgical products (B) in a reheating furnace (5) fitted with lateral burners. According to said method, the lateral burners are operated by on/off control, and the operating time and the down time of each burner is regulated in order to obtain the desired temperature. Inshot burners (1-4) are used as the lateral burners. Said burners are operated either at a speed which is close to the maximum speed or at the maximum speed, and the ignition order of the burners (1-4) is selected in such a way as to stimulate the stirring and circulation of the fumes in order to reduce the hot spot of the flame and to improve the homogeneity of the temperature of the walls of the furnace and the products.

Abstract: The invention relates to products comprising calcium, injectable magnesium and an injectable product which releases oxalate during the metabolism thereof as a combination that can be used for simultaneous, sequential or separate administration in anticancer and antiviral therapies.

Abstract: A method is disclosed for preheating a metal strip in at least one direct fired preheating section of a furnace for limiting the oxidation of the metal strip. The method includes installing burners in the preheating section along its length for establishing a plurality of preheating sub-zones of unit length corresponding to one burner. The air and fuel settings for each burner are adjusted in accordance with a desired heat demand. Subsequent steps include operating a variable number of downstream burners at full power to establish a preheating zone of variable length to produce the desired heat demand, and extinguishing a second variable number of upstream burners to establish a corresponding variable recovery zone.

Abstract: A fuse-holder clip including two lugs designed to define a space for receiving a fuse cartridge with circular cross-section. The lugs are folded along lines parallel to a central axis of the cartridge when the cartridge is placed in the clip such that each lug forms two electrical and mechanical lines of contact for engaging and supporting the cartridge with the two lines being globally parallel to the axis.

Abstract: Process for preheating metal, especially steel strip in direct-fired preheating sections for the purpose of limiting the oxidation of the heated metal strip, whatever the production configurations, which consists in using a preheating zone that can be divided, along its length, into a plurality of zones of unit length corresponding to one burner, it being possible for each of the said burners to be operated individually under fixed conditions so as to accurately adjust its air/gas setting, and therefore the resulting atmosphere in the furnace, wherein a certain number of burners starting from the downstream end of the preheating zone are ignited, the length of the furnace zone affected by the ignition of the said burners and the length of the recovery zone, i.e. the zone in which the burners are extinguished, being variable depending on the heat demand and in that each burner operates at full power and with a constant air/gas setting.

Abstract: The invention relates to a method for measuring the enzymatic activity of a convertase, wherein:(a) a biological sample containing the convertase is brought into contact with a labeled peptide substrate consisting of at least 10 AA, reproducing or mimicking the sequence of the precursor at the excision site, and(b) after conversion, the enzymatic activity of the sample is measured by determining the percentage of labeled conversion fragments relative to one or more standards.