Patents by Inventor Alain Nicolas
Alain Nicolas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11795465Abstract: The present invention relates to new transcriptional promoters that are functional during meiosis. It thus provides new tools, methods and compositions for the expression of proteins during meiosis in a eukaryotic cell, and more particularly in a plant cell.Type: GrantFiled: May 23, 2019Date of Patent: October 24, 2023Assignees: MEIOGENIX, INTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, ECOLE NORMALE SUPERIEURE DE LYONInventors: Giacomo Bastianelli, Alain Nicolas, Peter Rogowsky
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Publication number: 20230239459Abstract: An imaging pixel formed by a photodetector connected to a reading circuit comprising: an integration capacitance, a transistor for resetting the integration capacitance, a coupling transistor between the photodetector and the integration capacitance, a memorisation capacitance, a second transistor for resetting the memorisation capacitance, a memorisation switch between the integration capacitance and the memorisation capacitance, to enable different configurations corresponding to different phases of assessing parameters of the pixel and in particular a ratio R=Cint/Cmem.Type: ApplicationFiled: January 24, 2023Publication date: July 27, 2023Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventor: Jean-Alain NICOLAS
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Publication number: 20230174960Abstract: The present invention relates to a fusion protein comprising a domain of a nuclease from the class II CRISPR system, and a Spo11 domain, wherein both domains of the fusion protein have deficient nuclease activity, as well as the use of this protein to induce targeted meiotic recombinations in a eukaryotic cell.Type: ApplicationFiled: May 20, 2021Publication date: June 8, 2023Inventors: ALEXANDRE SERERO, ALAIN NICOLAS
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Publication number: 20230145351Abstract: Imager readout circuit comprising: an active reset stage of the integration capacitor equipped with a first current amplifier, a buffered direct injection bias stage of the photodetector equipped with transistors forming a second current amplifier, a switching circuit comprising a coupling stage integrated in the readout circuit, the switching circuit being controlled by control signals and being configured to: during a reset phase of the integration capacitor corresponding to a first state of said control signals: couple said first current source to the integration capacitor and activate the first current amplifier while uncoupling said second current source of the photodetector and deactivating the second amplifier, during an integration phase of a current from the photodiode and corresponding to a second state of said control signals, couple said second current source to the photodetector and activate the second current amplifier while uncoupling said first current source of the integration capacitor anType: ApplicationFiled: October 31, 2022Publication date: May 11, 2023Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventor: Jean-Alain NICOLAS
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Publication number: 20220162647Abstract: The present invention relates to a fusion protein comprising a Cas9 domain and a Spo11 domain, as well as the use of this protein to induce targeted meiotic recombinations in a eukaryotic cell.Type: ApplicationFiled: February 14, 2022Publication date: May 26, 2022Inventors: GIACOMO BASTIANELLI, ALEXANDRE SERERO, ALAIN NICOLAS
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Patent number: 11332218Abstract: An attachment of a stockless anchor on the sea floor encourages flukes to tilt as soon as the vessel pulls away, while maintaining stability on the floor. The weight of the flukes act as a pivot with the crown of the stockless anchor that, when placed on the floor, causes the anchor to become attached by being buried in the floor when the vessel pulls away. The attachment comprises two claws fastened to the flanks of the flukes at or in close proximity of the crown on the pivot axis of the flukes, thereby enabling them to tilt and become attached immediately in the floor as soon as the anchor is placed on the floor. When the vessel pulls away the anchor is open and becomes attached immediately. An attachment to the floor avoids or reduces dragging of the anchor on the floor.Type: GrantFiled: July 1, 2020Date of Patent: May 17, 2022Inventor: Alain Nicolas Maurin
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Patent number: 11248240Abstract: The present invention relates to a fusion protein comprising a Cas9 domain and a Spo11 domain, as well as the use of this protein to induce targeted meiotic recombinations in a eukaryotic cell.Type: GrantFiled: January 29, 2016Date of Patent: February 15, 2022Assignees: MEIOGENIX, INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, SORBONNE UNIVERSITEInventors: Giacomo Bastianelli, Alexandre Serero, Alain Nicolas
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Patent number: 11240459Abstract: External biasing control unit for a reading circuit of an infrared photodetector element, the control unit being able to adopt: a first configuration wherein it sends a first set of biasing signals to a first stage of the reading circuit so that this first stage adopts a first operating mode corresponding to a first biasing mode of the photodetector, in particular a direct injection mode, a second configuration wherein it sends a second set of biasing signals to said first stage, the signals in the second set being designed so that said first stage adopts a second operating mode corresponding to a second biasing mode of the photodetector, in particular a buffer direct injection mode.Type: GrantFiled: October 28, 2020Date of Patent: February 1, 2022Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventor: Jean-Alain Nicolas
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Publication number: 20210230619Abstract: The present invention relates to new transcriptional promoters that are functional during meiosis. It thus provides new tools, methods and compositions for the expression of proteins during meiosis in a eukaryotic cell, and more particularly in a plant cell.Type: ApplicationFiled: May 23, 2019Publication date: July 29, 2021Inventors: GIACOMO BASTIANELLI, ALAIN NICOLAS, PETER ROGOWSKY
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Publication number: 20210136306Abstract: External biasing control unit for a reading circuit of an infrared photodetector element, the control unit being able to adopt: a first configuration wherein it sends a first set of biasing signals to a first stage of the reading circuit so that this first stage adopts a first operating mode corresponding to a first biasing mode of the photodetector, in particular a direct injection mode, a second configuration wherein it sends a second set of biasing signals to said first stage, the signals in the second set being designed so that said first stage adopts a second operating mode corresponding to a second biasing mode of the photodetector, in particular a buffer direct injection mode.Type: ApplicationFiled: October 28, 2020Publication date: May 6, 2021Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventor: Jean-Alain NICOLAS
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Patent number: 10844367Abstract: The present invention relates to a method for improving an industrial yeast strain of industrial interest, particularly a sterile hybrid strain, without resorting to recombinant DNA techniques.Type: GrantFiled: November 29, 2013Date of Patent: November 24, 2020Assignees: INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE NICE SOPHIA ANTIPOLIS, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)Inventors: Alain Nicolas, Gianni Liti
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Publication number: 20200361570Abstract: An attachment of a stockless anchor on the sea floor encourages flukes to tilt as soon as the vessel pulls away, while maintaining stability on the floor. The weight of the flukes act as a pivot with the crown of the stockless anchor that, when placed on the floor, causes the anchor to become attached by being buried in the floor when the vessel pulls away. The attachment comprises two claws fastened to the flanks of the flukes at or in close proximity of the crown on the pivot axis of the flukes, thereby enabling them to tilt and become attached immediately in the floor as soon as the anchor is placed on the floor. When the vessel pulls away the anchor is open and becomes attached immediately. An attachment to the floor avoids or reduces dragging of the anchor on the floor.Type: ApplicationFiled: July 1, 2020Publication date: November 19, 2020Inventor: Alain Nicolas Maurin
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Patent number: 10766575Abstract: An attachment of a stockless anchor on the sea floor encourages flukes to tilt as soon as the vessel pulls away, while maintaining stability on the floor. The weight of the flukes act as a pivot with the crown of the stockless anchor that, when placed on the floor, causes the anchor to become attached by being buried in the floor when the vessel pulls away. The attachment comprises two claws fastened to the flanks of the flukes at or in close proximity of the crown on the pivot axis of the flukes, thereby enabling them to tilt and become attached immediately in the floor as soon as the anchor is placed on the floor. When the vessel pulls away the anchor is open and becomes attached immediately. An attachment to the floor avoids or reduces dragging of the anchor on the floor.Type: GrantFiled: September 7, 2016Date of Patent: September 8, 2020Inventor: Alain Nicolas Maurin
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Patent number: 10348284Abstract: A summing circuit, including a capacitor, a switching circuit capable of connecting the capacitor between a first node (ana) and a second node (ref), between a third node and the second node in a first connection direction or between the third node and the second node in a second connection direction, an integrator coupled to the third node, a hysteresis comparator coupled to the output of the integrator, and a counter coupled to the output of the hysteresis comparator.Type: GrantFiled: September 25, 2017Date of Patent: July 9, 2019Assignee: Commissariat à l'Énergie Atomique et aux Énergies AlternativesInventors: Jean-Pierre Rostaing, Bertrand Dupont, Nicolas Monnier, Jean-Alain Nicolas
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Publication number: 20190039693Abstract: An attachment of a stockless anchor on the sea floor encourages flukes to tilt as soon as the vessel pulls away, while maintaining stability on the floor. The weight of the flukes act as a pivot with the crown of the stockless anchor that, when placed on the floor, causes the anchor to become attached by being buried in the floor when the vessel pulls away. The attachment comprises two claws fastened to the flanks of the flukes at or in close proximity of the crown on the pivot axis of the flukes, thereby enabling them to tilt and become attached immediately in the floor as soon as the anchor is placed on the floor. When the vessel pulls away the anchor is open and becomes attached immediately. An attachment to the floor avoids or reduces dragging of the anchor on the floor.Type: ApplicationFiled: September 7, 2016Publication date: February 7, 2019Inventor: Alain Nicolas MAURIN
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Publication number: 20180091129Abstract: A summing circuit, including a capacitor, a switching circuit capable of connecting the capacitor between a first node (ana) and a second node (ref), between a third node and the second node in a first connection direction or between the third node and the second node in a second connection direction, an integrator coupled to the third node, a hysteresis comparator coupled to the output of the integrator, and a counter coupled to the output of the hysteresis comparator.Type: ApplicationFiled: September 25, 2017Publication date: March 29, 2018Applicant: Commissariat à l'Énergie Atomique et aux Énergies AlternativesInventors: Jean-Pierre Rostaing, Bertrand Dupont, Nicolas Monnier, Jean-Alain Nicolas
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Publication number: 20180023091Abstract: The present invention relates to a fusion protein comprising a Cas9 domain and a Spo11 domain, as well as the use of this protein to induce targeted meiotic recombinations in a eukaryotic cell.Type: ApplicationFiled: January 29, 2016Publication date: January 25, 2018Applicants: MEIOGENIX, INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)Inventors: GIACOMO BASTIANELLI, ALEXANDRE SERERO, ALAIN NICOLAS
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Publication number: 20150307868Abstract: The present invention relates to a method for improving an industrial yeast strain of industrial interest, particularly a sterile hybrid strain, without resorting to recombinant DNA techniquesType: ApplicationFiled: November 29, 2013Publication date: October 29, 2015Inventors: ALAIN NICOLAS, GIANNI LITI
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Patent number: 8232836Abstract: The invention relates to an integrated circuit comprising a succession of N identical elementary circuits (CE1, CE2, . . . CEN), juxtaposed in the order of their rank j varying from 1 to N, N being at least equal to 50, and all having to receive two reference potentials Vref and V0 supplied by two conductors. An upstream input of the second conductor is situated geographically on the side of the rank 1 of the succession of juxtaposed circuits, and an upstream input of the first conductor is situated geographically on the side of the rank N of the succession of juxtaposed circuits. This reduces the error in the potential difference applied to the elementary circuits all along the succession, an error that originates from the non-zero resistance of the conductors. The integrated circuit is applicable to analog-digital converters or digital-analog converters with high resolution.Type: GrantFiled: January 28, 2009Date of Patent: July 31, 2012Assignee: E2V SemiconductorsInventors: Jean-Alain Nicolas, Richard Morisson
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Patent number: 7999713Abstract: The invention relates to fast, high resolution, analog digital converters, and more particularly those which possess at least one conversion stage of “flash” type. The converter according to the invention uses N differential amplifiers with four inputs. The amplifier of rank j receives the input voltage to be converted Vep?Ven on two first inputs, and a reference potential difference on two other inputs. The reference potential difference is obtained between two taps of networks of resistors that are identical operating in parallel and supplied between a high voltage source and a low current source; the taps for an amplifier are respectively a tap Pj of rank j of a first network and a tap P?N?j+1 of rank N?j+1 of a second network. This reduces the first and second order non-linearity effects due to the fact that the differential amplifiers consume an input current tapped off from the networks of resistors.Type: GrantFiled: March 13, 2008Date of Patent: August 16, 2011Assignee: E2V SemiconductorsInventors: Jean-Alain Nicolas, Richard Morisson