Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: An apparatus for handling hot coal is provided, comprising —a cooling structure arranged to receive coal from a process chamber and to cool the coal in an atmosphere impeding ignition; and —a pneumatic conveyor system arranged to move coal by air pressure; wherein the cooling structure is configured to cool the coal to a surface temperature allowing the pneumatic conveyor system to convey the coal across a predetermined distance without the coal igniting.

Abstract: A torrefaction method comprises forwarding biomass through a process chamber; heating the biomass in the process chamber to a predetermined temperature and pyrolyzing the biomass to release syngas from the biomass, wherein the syngas contains at least 20% of the power contained in the flow of the biomass; and oxidizing the syngas to heat the biomass in the process chamber.

Abstract: A method to accumulate and pre-treat waste water prior to further processing. The method comprises accumulating waste water in a first and second tank and selectively adding further influent waste water to the first or second tank to such that the resultant pH from combining the influent waste water with the accumulated waste water results in a pH close to a target pH.

Abstract: Systems, methods, and devices directed to a button and corresponding applicator for an animal identification tag are provided. The applicator is employed to attach a button-tag assembly to the ear of an animal. The button includes a solid core embedded in the body of the button as well as a bladed edge at the tip of the core.

Abstract: A spray gun (1) has a fluid reservoir (11) with a removable liner (13) received in a container (12) having a detachable lid (15). The liner (13), which may be thermo/vacuum-formed from a planar material, has a shape that corresponds to and is a close fit within the interior of the container (12) and collapses as fluid is withdrawn from within the liner (13) during operation of the spray gun (1). The lid (15) has an outlet (16) connected to an inlet on the spray gun (1) for transfer of liquid from the reservoir (11) to the spray gun (1) and the container (12) has a vent (12A) in the base end for admitting air between the container (12) and the liner (13) as liquid is withdrawn from within the liner (13).

Abstract: The present invention relates generally to a protective helmet that includes a shell defining a shell exterior and a shell interior configured to protectively receive a wearer's head. The helmet also includes an internal support disposed in the shell interior in supportive association with the shell for supporting the shell on the wearer's head, and an adjustment member associated with the internal support for adjusting the size of the internal support to fit to the wearer's head. The adjustment member and the shell are configured and dimensioned such that the adjustment member is operable to adjust the internal support from outside the shell while the helmet is mounted on the wearer's head.

Abstract: A device connected between a source of power and at least one load for selectively providing power from the source of power to the at least one load to operate in an area responsive to an environmental condition in the area. In one embodiment, the device includes a home mode, an away mode, and a custom mode, and a user interface for selecting one of the home mode and the custom mode to be operated.

Abstract: A spray gun (1) has a fluid reservoir (11) with a removable liner (13) received in a container (12) having a detachable lid (15). The liner (13), which may be thermo/vacuum-formed from a planar material, has a shape that corresponds to and is a close fit within the interior of the container (12) and collapses as fluid is withdrawn from within the liner (13) during operation of the spray gun (1). The lid (15) has an outlet (16) connected to an inlet on the spray gun (1) for transfer of liquid from the reservoir (11) to the spray gun (1) and the container (12) has a vent (12A) in the base end for admitting air between the container (12) and the liner (13) as liquid is withdrawn from within the liner (13).

Abstract: A spray gun (1) has a fluid reservoir (11) with a removable liner (13) received in a container (12) having a detachable lid (15). The liner (13), which may be thermo/vacuum-formed from a planar material, has a shape that corresponds to and is a close fit within the interior of the container (12) and collapses as fluid is withdrawn from within the liner (13) during operation of the spray gun (1). The lid (15) has an outlet (16) connected to an inlet on the spray gun (1) for transfer of liquid from the reservoir (11) to the spray gun (1) and the container (12) has a vent (12A) in the base end for admitting air between the container (12) and the liner (13) as liquid is withdrawn from within the liner (13).

Abstract: A calibration cartridge (20) for an automated media library (60) comprises a cartridge case (30) having a calibration surface (35) and an electromagnetic transmissive channel (40). The electromagnetic transmissive channel transmits electromagnetic radiation incident upon the calibration surface at a radiation reception port (42) in a first position of the calibration cartridge so that the electromagnetic radiation travels interiorily through the calibration case and exits from the calibration cartridge at a radiation exit aperture (44) in a second position on the calibration surface. The calibration cartridge is usable in an automated information storage library which comprises plural cartridge-accommodating cells (64) and a drive (68).

Abstract: A calibration cartridge (20) for an automated media library (60) comprises a cartridge case (30) having a calibration surface (35) and an electromagnetic transmissive channel (40). The electromagnetic transmissive channel transmits electromagnetic radiation incident upon the calibration surface at a radiation reception port (42) in a first position of the calibration cartridge so that the electromagnetic radiation travels interiorily through the calibration case and exits from the calibration cartridge at a radiation exit aperture (44) in a second position on the calibration surface. The calibration cartridge is usable in an automated information storage library which comprises plural cartridge-accommodating cells (64) and a drive (68).

Abstract: A pipe coupling for the joining of plain end plastic or metallic pipe that includes an annular follower, a tubular middle ring extending between opposite followers, an annular gasket within the follower contiguous to the middle ring and a restrainer unit within the follower comprising a lock ring having a plurality of arcuately spaced radial slots for slideably supporting individual gripper segments that are operative during tightening installation of the follower about a received pipe end to effect a penetrating restraining grip against the surface of the pipe end.

Abstract: This relates to coaxial magnetrons and to a tuning arrangement for the stabilizing cavity including a fixed tuning element and a movable tuning element which is continuously and unidirectionally displaceable for repetitive cooperation with the fixed element. The arrangement is particularly suitable for "ditherable" or frequency-agile megnetrons.