Abstract: The present disclosure provides methods of treating a disease or disorder in a patient comprising administering 5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione (“Compound (1)”), or a pharmaceutically acceptable salt thereof, to the patient, wherein the patient achieves a threshold steady-state plasma concentration of Compound (1). The present disclosure also provides methods of administering a therapeutically effective amount of Compound (1), or a pharmaceutically acceptable salt thereof, to a patient. Compound (1) is a PPAR-? agonist that is used to treat a variety of diseases and disorders including, but not limited to, nonalcoholic steatohepatitis and central nervous system diseases, e.g., X-linked adrenoleukodystrophy, Friedreich's Ataxia.

Abstract: The present invention relates to a wireless communication system for controlling one or more remote automated mining assets. The system includes a high-altitude platform including at least one high altitude communication apparatus, and for communicating control messages for the mining assets. A low-altitude platform includes at least one low altitude communication apparatus, and is suitable for communicating control messages for the mining assets. Preferably, the high-altitude platform is a long-term communications platform whereas the low-altitude platform is a short-term communications platform that can be more rapidly deployed and flexibly restructured.

Abstract: There is proposed a bladed rotor for a turbo-machine, the rotor having a rotational axis and including a hub defining a plurality of circumferentially spaced-apart slots around its periphery. Each slot slideably receives a root portion of a respective rotor blade, the root portion of each blade defining a radially inwardly open retaining groove within which a respective region of a retaining ring locates to retain the blades in said slots. The retaining ring also engages within a plurality of radially inwardly open hub grooves formed around the hub. The retaining ring engages each said hub groove such that a radial gap is defined between the retaining ring and a radially outermost region of each hub groove.

Abstract: There is proposed a bladed rotor for a turbo-machine, the rotor having a rotational axis and including a hub defining a plurality of circumferentially spaced-apart slots around its periphery. Each slot slideably receives a root portion of a respective rotor blade, the root portion of each blade defining a radially inwardly open retaining groove within which a respective region of a retaining ring locates to retain the blades in said slots. The retaining ring also engages within a plurality of radially inwardly open hub grooves formed around the hub. The retaining ring engages each said hub groove such that a radial gap is defined between the retaining ring and a radially outermost region of each hub groove .

Abstract: A blasting method for beneficiating minerals comprising mining of a geological body (10) including a value portion (20) having at least a threshold content of a mineral to be extracted and a waste portion (30) relatively lean in content of a mineral to be extracted wherein mining comprises controlled blasting of the geological body (10) such that the value portion (20) fragments differently than the waste portion (30), the difference in fragmentation between the value portion (20) and the waste portion (30) enabling separation of a mineral stream concentrated in the mineral to be extracted from the waste portion (30).

Abstract: Disclosed is the compound (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol and pharmaceutically acceptable salts and solvates thereof, pharmaceutical compositions comprising them, and processes for their preparation; also disclosed is a method of treating depression, attention deficit hyperactivity disorder (ADHD), obesity, migraine, pain, sexual dysfunction, Parkinson's disease, Alzheimer's disease, addiction to cocaine or tobacco products, seasonal affective disorder, chronic fatigue, narcolepsy or cognitive impairment using such compound, salts, solvates or compositions.

Abstract: Disclosed is the compound (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol and pharmaceutically acceptable salts and solvates thereof, pharmaceutical compositions comprising them, and processes for their preparation; also disclosed is a method of treating depression, attention deficit hyperactivity disorder (ADHD), obesity, migraine, pain, sexual dysfunction, Parkinson's disease, Alzheimer's disease, addiction to cocaine or tobacco products, seasonal affective disorder, chronic fatigue, narcolepsy or cognitive impairment using such compound, salts, solvates or compositions.

Abstract: The present invention provides a chewable ranitidine tablet comprising ranitidine, or a physiologically acceptable salt thereof, a chewable base selected from sucrose, glucose, lactose, maltose, or a mixture thereof, a flavouring and, optionally, an intense sweetener and a process for its preparation.