Abstract: Devices and methods useful for balancing high-pressure spools of gas turbine engines are disclosed. An exemplary device may comprise: an input shaft configured to be coupled to an output of an accessory gear box driven by a high-pressure spool of a gas turbine engine; a first trigger rotatably coupled to the input shaft at a first speed ratio; and a sensor configured to detect the trigger at each revolution of the trigger. The first speed ratio may permit a rotational speed of the first trigger to be substantially the same as a rotational speed of the high-pressure spool. Upon detection of the trigger, the sensor may generate one or more signals representative of each associated revolution of the high-pressure spool of the gas turbine engine.

Abstract: Devices and methods useful for balancing high-pressure spools of gas turbine engines are disclosed. An exemplary device may comprise: an input shaft configured to be coupled to an output of an accessory gear box driven by a high-pressure spool of a gas turbine engine; a first trigger rotatably coupled to the input shaft at a first speed ratio; and a sensor configured to detect the trigger at each revolution of the trigger. The first speed ratio may permit a rotational speed of the first trigger to be substantially the same as a rotational speed of the high-pressure spool. Upon detection of the trigger, the sensor may generate one or more signals representative of each associated revolution of the high-pressure spool of the gas turbine engine.

Abstract: A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(?O)— or —O—; Y is an optionally substituted C1-5 alkylene group; X is selected from SR3 or NR4R5, wherein, R3, or R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(?O)—NR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl gro

Abstract: Compounds of formula I: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N; and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; and where Z is selected from S, O, C(?O), CH2 and NH are disclosed for use in inhibiting DNA-PK.

Abstract: The invention relates to the use of compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, in the preparation of a medicament for inhibiting the activity of DNA-PK, wherein R1 and R2 are independently hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; X and Y are selected from CR4 and O, O and CR?4 and NR?4 and N, where the unsaturation is in the appropriate place in the ring, and where one of R3 and R4 or R?4 is an optionally substituted C3-20 heteroaryl or C5-20 aryl group, and the other of R3 and R4 or R?4 is H, or R3 and R4 or R?4 together are —A—B—, which collectively represent a fused optionally substituted aromatic ring. The compounds also selectively inhibit the activity of DNA-PK compared to PI 3-kinase and/or ATM.

Abstract: A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(?O)— or —O—; Y is an optionally substituted C1-5 alkylene group; X is selected from SR3 or NR4R5, wherein, R3, or R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(?O)—NR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl gro

Abstract: A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(?O)— or —O—; Y is an optionally substituted C1-5 alkylene group; X is selected from SR3 or NR4R5, wherein, R3, or R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(?O)—NR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl

Abstract: Apparatus for use in a storage and retrieval system for product held in containers is provided. The apparatus includes multiple, parallel spaced-apart support members (41) defining a plurality of rows (20), each adapted to support a base of a plurality of containers thereby forming a container store. One or more conveying means (44) is engageable with containers in a row (20) to transport the containers longitudinally within that row, the conveying means (44) movable transverse and below the rows. One or more loading means (45) is movable transverse to the rows (20) along an end of the rows to enable loading of one or more containers into a selected row. A computer control system automatically controls operation of the loading means and conveying means. The loading means (45) may include a transfer conveyor (49) extending beneath at least a portion of said rows and moveable transverse to said rows below said rows.

Abstract: The invention relates to the use of compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, in the preparation of a medicament for inhibiting the activity of DNA-PK, wherein R1 and R2 are independently hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; X and Y are selected from CR4 and O, O and CR?4 and NR?4 and N, where the unsaturation is in the appropriate place in the ring, and where one of R3 and R4 or R?4 is an optionally substituted C3-20 heteroaryl or C5-20 aryl group, and the other of R3 and R4 or R?4 is H, or R3 and R4 or R?4 together are -A-B—, which collectively represent a fused optionally substituted aromatic ring. The compounds also selectively inhibit the activity of DNA-PK compared to PI 3-kinase and/or ATM.

Abstract: The present invention provides compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein R1 and R2 are independently hydrogen, an option ally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and R3 is an optionally substituted C3-20 heterocyclyl or C5-20 aryl group, and their use as pharmaceuticals, particularly in treating diseases which are retroviral mediated or ameliorated by the inhibition of DNA-PK,

Abstract: A method for storing and transporting containers is provided. The method includes arranging containers in a container store (101A, 101B) in one or more rows of stacks or partial stacks. Stacks or partial stacks are transported by engaging with one or more containers using a movable engagement means (19) that engages with the containers from their side. The engagement means (19) moves the containers next to the rows before moving them along the row to a required location for placement on a partial stack or on a support surface. Also provided is apparatus for transporting containers and a method of container handling that involves only removing and storing excess containers from a flow of containers in order to fulfill an order.

Abstract: The invention relates to the use of compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, in the preparation of a medicament for inhibiting the activity of DNA-PK, wherein R1 and R2 are independently hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; X and Y are selected from CR4 and O, O and CR′4 and NR″4 and N, where the unsaturation is in the appropriate place in the ring, and where one of R3 and R4 or R′4 is an optionally substituted C3-20 heteroaryl or C5-20 aryl group, and the other of R3 and R4 or R′4 is H, or R3 and R4 or R″4 together are —A—B—, which collectively represent a fused optionally substituted aromatic ring.

Abstract: Protecting coverings are provided for glass windows and the like. The protective coverings comprise a fiber reinforced polymeric fabric flexible enough to be rolled upon itself.

Abstract: Protective coverings are provided for glass windows and the like. The protective coverings comprise impact and puncture resistant protective panels formed from strand material which includes reinforcing fibers and polymeric material.

Abstract: An appliance backsplash assembly includes an appliance housing with a top member. A control housing assembly includes a rear wall and a pair of end caps mounted adjacent the rear portion of the top member. The control housing also includes a control panel assembly with a mounting plate and a cover. The mounting plate has tabs spaced across its bottom edge with slots therein. The cover includes tabs spaced apart across its bottom edge and received in the slots in the mounting plate tabs. The mounting plate tabs are received slots in the rear portion of the top member so that the mounting plate can be pivoted to a position exposing one of its faces. Controls are mounted to the mounting plate through that face to be removable when that face is exposed.

Abstract: A top assembly for an appliance, such as a top loading clothes washer, includes a top support member. A top panel is attached to and positioned over the support member. The top panel terminates forward of the rear of the support member and includes a rear portion extending side to side of the support member. A control housing includes an assembly of a rear wall and end caps. The end caps are mounted on the support member and extend rearward of the rear portion of the top panel and the rear wall extends across the rear of the support member. The control housing also includes a control panel assembly mounted on the rear portion of the top panel and attached to the rear wall and end cap assembly.