Abstract: Cartridge-based thermocyclers can include cartridges that are configured to move a fluid between distinct chambers. In some cases, the cartridge-based thermocyclers can be used for thermocycling a sample fluid comprising a deoxyribonucleic acid (DNA) target to perform polymerase chain reaction (PCR). Individual chambers can be heated, cooled, and/or compressed to mix fluid within the chamber or to propel fluid in the chamber into another chamber. The cartridges can have a laminate construction. The cartridges can be configured to enable multiplexed thermocycling and/or detection.

Abstract: Cartridge-based thermocyclers can include cartridges that are configured to move a fluid between distinct chambers. In some cases, the cartridge-based thermocyclers can be used for thermocycling a sample fluid comprising a deoxyribonucleic acid (DNA) target to perform polymerase chain reaction (PCR). Individual chambers can be heated, cooled, and/or compressed to mix fluid within the chamber or to propel fluid in the chamber into another chamber. The cartridges can have a laminate construction. The cartridges can be configured to enable multiplexed thermocycling and/or detection.

Abstract: Cartridge-based thermocyclers can include cartridges that are configured to move a fluid between distinct chambers. In some cases, the cartridge-based thermocyclers can be used for thermocycling a sample fluid comprising a deoxyribonucleic acid (DNA) target to perform polymerase chain reaction (PCR). Individual chambers can be heated, cooled, and/or compressed to mix fluid within the chamber or to propel fluid in the chamber into another chamber. The cartridges can have a laminate construction. The cartridges can be configured to enable multiplexed thermocycling and/or detection.

Abstract: Cartridge-based thermocyclers can include cartridges that are configured to move a fluid between distinct chambers. In some cases, the cartridge-based thermocyclers can be used for thermocycling a sample fluid comprising a deoxyribonucleic acid (DNA) target to perform polymerase chain reaction (PCR). Individual chambers can be heated, cooled, and/or compressed to mix fluid within the chamber or to propel fluid in the chamber into another chamber. The cartridges can have a laminate construction. The cartridges can be configured to enable multiplexed thermocycling and/or detection.

Abstract: A device for monitoring human feet can include: a transmissive sheet configured to bear at least 90 kg supported at a height of no more than 23 cm, and a foot image capture system below the sheet. An optical image sensor can capture a field of view including at least 250 cm2 of the surface of the sheet. The device can have a central reflective element positioned below the sheet directly above the sensor and two outer mirrors such that two fields of view at least 250 cm2 each can be focused onto the sensor by a lens. Foot sole images can be automatically captured when a patient stands on the device. Images can be transmitted to a database and associated with the patient by analyzing the images for a unique predetermined metric.

Abstract: The present invention pertains to a device and method for imaging of a human foot including a transmissive sheet with an upper surface configured to accommodate a sole of the foot, a light source positioned below the sheet for emitting light toward the sheet, and an optical path controller in the sheet or coupled to the sheet for altering a path of the light causing internal reflection of the light toward a predetermined region of the foot. The image can be analyzed for a predetermined characteristic associated with a human patient, and determination made whether the characteristic in the image matches the patient. Brightness in the image can be analyzed for tissue moisture information.

Abstract: The present disclosure provides systems and methods for the optical detection of a plurality of labeled substrates in an assay. The various aspects of the optical detection systems enable the simultaneous detection of the plurality of labeled substrates. These systems are particularly useful in the detection of nucleic acids during an amplifications reaction.

Abstract: Cartridge-based thermocyclers can include cartridges that are configured to move a fluid between distinct chambers. In some cases, the cartridge-based thermocyclers can be used for thermocycling a sample fluid comprising a deoxyribonucleic acid (DNA) target to perform polymerase chain reaction (PCR). Individual chambers can be heated, cooled, and/or compressed to mix fluid within the chamber or to propel fluid in the chamber into another chamber. The cartridges can have a laminate construction. The cartridges can be configured to enable multiplexed thermocycling and/or detection.

Abstract: The present invention pertains to a device and method for imaging of a human foot including a transmissive sheet with an upper surface configured to accommodate a sole of the foot, a light source positioned below the sheet for emitting light toward the sheet, and an optical path controller in the sheet or coupled to the sheet for altering a path of the light causing internal reflection of the light toward a predetermined region of the foot. The image can be analyzed for a predetermined characteristic associated with a human patient, and determination made whether the characteristic in the image matches the patient. Brightness in the image can be analyzed for tissue moisture information.

Abstract: The present invention pertains to a device and method for monitoring of human feet including a transmissive sheet configured to bear at least 90 kg supported at a height of no more than 23 cm and having a foot image capture system below the sheet wherein an optical image sensor can capture a field of view including at least 250 cm2 of the surface of the sheet. The device can have a central reflective element positioned below the sheet directly above the sensor and two outer mirrors such that two fields of view at least 250 cm2 each can be focused onto the sensor by a lens. Foot sole images can be automatically captured when the patient stands on the device. Images can be transmitted to a database and associated with a patient by analyzing the images for a unique predetermined metric.

Abstract: A dewatering screen is manufactured by laying screen wires (40) in the parallel grooves (18) of a number of support members (13) so as to form a frusto-conical wire array. The support members (13) are movable inwardly to release the screen wire array, after the wire array has been bound by continuously welding a support rod (44) to the screen wires (40) as the support rod (44) is wrapped about the wire array.