Patents by Inventor Alan D. Strickland
Alan D. Strickland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20140286894Abstract: The present disclosure relates generally to crosslinked cation-binding polymers comprising monomers containing carboxylic acid groups, wherein the polymer contains calcium and/or magnesium cations that are counterions to about 15% to about 35% of the carboxylic acid groups in the polymer. The present disclosure also relates to methods of preparation of the polymers, and compositions, formulations, and dosage forms containing the polymers, and methods of using the polymers, compositions, formulations, and/or dosage forms to treat various diseases or disorders, including those involving ion and/or fluid imbalances.Type: ApplicationFiled: January 10, 2012Publication date: September 25, 2014Applicant: Sorbent Therapeutics, Inc.Inventors: Alan D. Strickland, George M. Grass
-
Publication number: 20130195975Abstract: The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states. In one embodiment, the subject method involves ingesting an enterically coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polymers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, from the G.I. tract.Type: ApplicationFiled: August 20, 2012Publication date: August 1, 2013Applicant: SORBENT THERAPEUTICS, INC.Inventors: Jaime Simon, Alan D. Strickland
-
Patent number: 8263112Abstract: The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states. In one embodiment, the subject method involves ingesting an enterically coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polymers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, from the G.I. tract.Type: GrantFiled: May 6, 2004Date of Patent: September 11, 2012Assignee: Sorbent Therapeutics, Inc.Inventors: Jaime Simon, Alan D. Strickland
-
Patent number: 7794994Abstract: Described are enzyme systems specific for acetone and methods of using these enzyme systems to detect acetone in biological or environmental samples. Biosensors containing these enzyme systems are disclosed, in which detection of acetone may be achieved by linking electrochemical, photometric, or other detection means to one or more acetone-specific enzyme reactions or pathways. Methods of using such acetone-specific biosensors include subject management of weight loss, disease detection, and bioavailability monitoring of therapeutics.Type: GrantFiled: November 8, 2002Date of Patent: September 14, 2010Assignee: Kemeta, LLCInventors: Paul E. Cranley, Jeffrey R. Allen, Kristine L. Danowski, James A. McIntyre, Theodore E. Miller, Jr., Bettina M. Rosner, Alan D. Strickland, Venkiteswaran Subramanian, Larry Sun
-
Publication number: 20090258088Abstract: This invention has as one of its aspects a method to provide a safe an effective treatment for synovectomy. The method involves the administration a material to the affected joint, allowing the material to localize in the synovial membrane, and then applying an external stimulus that interacts with the material to provide therapy. The materials of this invention are preferably particles, which are either magnetic or contain a heavy element. The external stimuli of this invention includes an alternating magnetic field to heat magnetic particles, infrared laser to heat heavy elements, or electromagnetic ionizing radiation (X- or gamma-radiation) that interacts with heavy elements to produce a localized radiation dose.Type: ApplicationFiled: October 24, 2007Publication date: October 15, 2009Applicant: Iso Therapeutics Group LLCInventors: R. Keith Frank, Kenneth McMillan, Jaime Simon, Alan D. Strickland
-
Publication number: 20090252675Abstract: The compounds used in this method for the treatment of bladder cancer comprise a radioisotope particle emitter, such as alpha- or beta-emitters or low energy gamma-emitters, associated with a chelating agent (for metallic radioisotopes) or other compound (by covalent bond for iodine or other non-metals) selected such that these permit delivery of the radionuclide by an I.V. injection that is then cleared into the bladder by the kidneys. Furthermore, it is expected that these radioisotopes are formulated with customary pharmaceutically-acceptable salts, adjuvants, binders, desiccants, diluents, and excipients.Type: ApplicationFiled: March 23, 2007Publication date: October 8, 2009Inventors: R. Keith Frank, Daniel J. Macey, Jaime Simon, Alan D. Strickland
-
Patent number: 7045116Abstract: This invention relates to medical uses of radiopharmaceuticals. Specifically, the present invention relates to the use of radiopharmaceuticals to treat osteomyelitis. The present invention provides improved system and methods of for the direct delivery of radiopharmaceuticals to the site of osteomyelitis.Type: GrantFiled: December 11, 2002Date of Patent: May 16, 2006Assignee: Dow Global Technologies Inc.Inventors: Dana W. Simon, Alan D. Strickland, Jaime Simon, Daniel J. Macey, R. Keith Frank, Kenneth McMillan
-
Patent number: 6908609Abstract: The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states. In one embodiment, the subject method involves ingesting an enterically coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polymers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, from the G.I. tract.Type: GrantFiled: November 6, 2001Date of Patent: June 21, 2005Assignee: Dow Global Technologies Inc.Inventors: Jaime Simon, Alan D. Strickland
-
Patent number: 6861044Abstract: The present invention concerns the use of a radioiodinated phenolic compound of the formula wherein: m and n are independently 0, 1, 2 or 3, X is a group that is negatively or positively charged at physiological pH, R, R1, R2 and R3 are independently hydrogen, C1-C4 alkyl, or a carboxyl group, and I* is 123I, 131I or 125I, and its pharmaceutically-acceptable salts. The compound is formulated and used in vivo in an animal in brachytherapy in an implantable catheter. In addition, due to the rapid renal clearance of these compounds, they may be used to study renal function. A process to prepare these compounds is also disclosed.Type: GrantFiled: December 18, 2001Date of Patent: March 1, 2005Assignee: The Dow Chemical CompanyInventors: Jaime Simon, R. Keith Frank, Alan D. Strickland
-
Publication number: 20040170600Abstract: The present invention is directed to a water-soluble polyether glycol polymer having: a structural backbone of carbon atoms and oxygen atoms where there are at least two consecutive carbon atoms present between each oxygen atom; a moiety on the backbone of the polymer or a functionalized derivative on the polymer, that is cationic at physiological pH and permits complexation with phosphate or oxalate; and an average molecular weight from about 5,000 to about 750,000 Daltons. These polymers are formulated for oral dosage to reduce the phosphonate or oxalate levels in an animal. The process of preparing these polymers and the method of reducing gastrointestinal absorption of phosphate and oxalate are included.Type: ApplicationFiled: March 2, 2004Publication date: September 2, 2004Inventors: Jaime Simon, Tipton Thomas Masterson, Alan D. Strickland, Martha L. Hilton
-
Publication number: 20030228256Abstract: A method for achieving hemolymphopoietic chimerism is disclosed. The method involves the steps of administering to a recipient a bone seeking radiopharmaceutical; transplanting bone marrow-derived cells into the recipient; and transiently suppressing lymphocyte response so as to induce hemolymphopoietic chimerism. The method is useful for decreasing rejection of transplanted organs, tissues or cells and for treating autoimmune diseases. The present invention has the advantage of inducing hemolymphopoietic chimerism without the need for external radiation or harsh cytotoxic drugs. The present invention has the additional advantage of significantly prolonging tolerance to an organ, cell, or tissue transplant.Type: ApplicationFiled: December 10, 2002Publication date: December 11, 2003Inventors: Luca A. Inverardi, Camillo Ricordi, Giovanni Paganelli, Aldo N. Serafini, Jaime Simon, Alan D. Strickland
-
Publication number: 20030202958Abstract: Dialysis solutions comprising aqueous solutions including physiologically acceptable salts and a polyglycol osmotic agent are disclosed. The subject solutions provide an improved osmotic gradient resulting in reduced dialysis times and/or reduced volumes of required dialysis solution. Moreover, the subject osmotic agents do not significantly migrate into the patient's blood over the time period of dialysis nor are the subject osmotic agents as susceptible to forming detrimental degradation products during gamma sterilization. The use of free radical scavengers is also described along with the use of a filter to reduce the introduction of bacteria into the peritoneal cavity.Type: ApplicationFiled: March 25, 2003Publication date: October 30, 2003Inventors: Alan D. Strickland, Jaime Simon
-
Patent number: 6609068Abstract: A medical breath component analyzer which maintains a data-base profile of a patient over time. The apparatus may be used chronically by a patient so that a baseline status for that patient may be determined. Acute variations from the baseline are identified as clinically significant. The acquired data can be reported to the patient using the device at home and transmitted electronically to a physician or health care provider. The method and apparatus helps a patient modify health related behaviors, particularly weight loss for diabetic patients. A breath component and information on the psychological or emotional state of the patient are correlated, and information is provided to the patient based on the correlation between the breath component and the patient's emotional state. Other physiologic parameter may also be measured, such as a blood component, temperature, cardiovascular condition or pulse rate, a urine component, a physical activity sensor, weight, or body fat composition sensor.Type: GrantFiled: March 5, 2001Date of Patent: August 19, 2003Assignee: Dow Global Technologies Inc.Inventors: Paul E. Cranley, James D. Tate, Ted E. Miller, Alan D. Strickland, Charles J. McDonald, Michael J. Bartels, Alan K. Schrock, Scott P. Crane
-
Publication number: 20030118508Abstract: This invention relates to medical uses of radiopharmaceuticals. Specifically, the present invention relates to the use of radiopharmaceuticals to treat osteomyelitis. The present invention provides improved system and methods of for the direct delivery of radiopharmaceuticals to the site of osteomyelitis.Type: ApplicationFiled: December 11, 2002Publication date: June 26, 2003Inventors: Dana W. Simon, Alan D. Strickland, Jaime Simon, Daniel J. Macey, R. Keith Frank, Kenneth McMillan
-
Patent number: 6506364Abstract: The present invention concerns the use of a radioiodinated phenolic compound of the formula wherein: m and n are independently 0, 1, 2 or 3, X is a group that is negatively or positively charged at physiological pH, R, R1, R2 and R3 are independently hydrogen, C1-C4 alkyl, or a carboxyl group, and I* is 123I, 131I or 125I, and its pharmaceutically-acceptable salts. The compound is formulated and used in vivo in an animal in brachytherapy in an implantable catheter. In addition, due to the rapid renal clearance of these compounds, they may be used to study renal function. A process to prepare these compounds is also disclosed.Type: GrantFiled: September 28, 2000Date of Patent: January 14, 2003Assignee: The Dow Chemical CompanyInventors: Jaime Simon, Alan D. Strickland, R. Keith Frank
-
Patent number: 6506363Abstract: The present invention concerns the use of a radioiodinated phenolic compound of the formula wherein: m and n are independently 0, 1, 2 or 3, X is a group that is negatively or positively charged at physiological pH, R, R1, R2 and R3 are independently hydrogen, C1-C4 alkyl, or a carboxyl group, and I* is 123I, 131I or 125I, and its pharmaceutically-acceptable salts. The compound is formulated and used in vivo in an animal in brachytherapy in an implantable catheter. In addition, due to the rapid renal clearance of these compounds, they may be used to study renal function. A process to prepare these compounds is also disclosed.Type: GrantFiled: September 28, 2000Date of Patent: January 14, 2003Assignee: The Dow Chemical CompanyInventors: Jaime Simon, R. Keith Frank, Alan D. Strickland
-
Patent number: 6465690Abstract: A process for preparing polyamino monosuccinic acids, salts or chelates thereof by (a) reacting a maleic or fumaric acid ester or mixtures thereof with a polyamino compound in a primary alcohol as a solvent, (b) hydrolyzing the product obtained in step (a), and (c) separating the primary alcohol. The use of a primary alcohol as the solvent results in a markedly purer polyamino monosuccinic acid product and simpler reaction conditions than when the solvent is a secondary or tertiary alcohol.Type: GrantFiled: February 23, 2000Date of Patent: October 15, 2002Assignee: The Dow Chemical CompanyInventors: Alan D. Strickland, David A. Wilson, Brian D. Burkholder, Druce K. Crump
-
Publication number: 20020146386Abstract: The subject invention is a method and material for removing fluid from the intestinal tract of a host and may be useful in treating animals or human patients suffering from fluid overload states. In one embodiment, the subject method involves ingesting an enterically coated non-systemic, non-toxic, non-digestible, water absorbing polymer which absorbs fluid while passing through the intestinal tract. The polymer is excreted in the feces wherein the polymer and absorbed fluid is removed from the body. Preferred polymers include super absorbent acrylic acid polymers, preferably provided in bead form. The polymers may include functional groups for selectively removing blood borne waste products, e.g. urea, from the G.I. tract.Type: ApplicationFiled: November 6, 2001Publication date: October 10, 2002Inventors: Jaime Simon, Alan D. Strickland
-
Publication number: 20020081662Abstract: The present invention concerns the use of a radioiodinated phenolic compound of the formula 1Type: ApplicationFiled: December 18, 2001Publication date: June 27, 2002Inventors: Jaime Simon, R. Keith Frank, Alan D. Strickland
-
Publication number: 20020064511Abstract: The present invention is directed to a water-soluble polyether glycol polymer having: a structural backbone of carbon atoms and oxygen atoms where there are at least two consecutive carbon atoms present between each oxygen atom; a moiety on the backbone of the polymer or a functionalized derivative on the polymer, that is cationic at physiological pH and permits complexation with phosphate or oxalate; and an average molecular weight from about 5,000 to about 750,000 Daltons. These polymers are formulated for oral dosage to reduce the phosphonate or oxalate levels in an animal. The process of preparing these polymers and the method of reducing gastrointestinal absorption of phosphate and oxalate are included.Type: ApplicationFiled: June 26, 2001Publication date: May 30, 2002Inventors: Jaime Simon, Alan D. Strickland, Tipton Thomas Masterson, Martha L. Hilton