Patents by Inventor Alan F. Wahl

Alan F. Wahl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bispecific binding proteins that bind CD40 and mesothelin
    Patent number: 10233258
    Abstract: The present disclosure provides bispecific proteins that bind to two antigens, as well as their compositions, uses, and methods of making.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: March 19, 2019
    Assignee: AbbVie Biotherapeutics Inc.
    Inventors: Yoshiko Akamatsu, Patricia Culp, Charles M. Forsyth, Ping Y. Huang, David Powers, Alan F. Wahl, Shiming Ye
  • BISPECIFIC BINDING PROTEINS
    Publication number: 20180194862
    Abstract: The present disclosure provides bispecific proteins that bind to two antigens, as well as their compositions, uses, and methods of making.
    Type: Application
    Filed: February 23, 2018
    Publication date: July 12, 2018
    Inventors: Yoshiko AKAMATSU, Patricia CULP, Charles M. FORSYTH, Ping Y. HUANG, David POWERS, Alan F. WAHL, Shiming YE
  • BISPECIFIC BINDING PROTEINS
    Publication number: 20170342169
    Abstract: The present disclosure provides bispecific proteins that bind to two antigens, as well as their compositions, uses, and methods of making.
    Type: Application
    Filed: May 26, 2017
    Publication date: November 30, 2017
    Inventors: Yoshiko AKAMATSU, Patricia Culp, Charles M. Forsyth, Ping Y. Huang, David Powers, Alan F. Wahl, Shiming Ye
  • Treatment of renal cell carcinoma with anti-CD70 antibody-drug conjugates
    Patent number: 9345785
    Abstract: Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing a cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: May 24, 2016
    Assignee: Seattle Genetics, Inc.
    Inventors: Che-Leung Law, Alan F. Wahl, Nathalie Scholler, Linda A. Pestano
  • Anti-CD70 antibody and its use for the treatment of cancer and immune disorders
    Patent number: 9051372
    Abstract: Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunosuppressive without conjugation to a therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody or derivative. Also disclosed are methods for the treatment and prevention of CD70-expressing cancers and immunological disorders comprising administering to a subject the CD70-binding agent.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: June 9, 2015
    Assignee: Seattle Genetics, Inc.
    Inventors: Che-Leung Law, Julie McEarchern, Alan F. Wahl
  • Treatment of immune disorders with anti-CD70 antibody
    Patent number: 8647624
    Abstract: Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunosuppressive without conjugation to a therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody or derivative. Also disclosed are methods for the treatment and prevention of CD70-expressing cancers and immunological disorders comprising administering to a subject the CD70-binding agent.
    Type: Grant
    Filed: January 18, 2008
    Date of Patent: February 11, 2014
    Assignee: Seattle Genetics, Inc.
    Inventors: Che-Leung Law, Julie McEarchern, Alan F. Wahl
  • Treatment of B-cell cancers with anti-CD70 antibody-drug conjugates
    Patent number: 8609104
    Abstract: Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of a CD70-expressing cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: December 17, 2013
    Assignee: Seattle Genetics, Inc.
    Inventors: Che-leung Law, Alan F. Wahl, Nathalie Scholler, Linda A. Pestano
  • Anti-CD70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders
    Patent number: 8535678
    Abstract: Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: September 17, 2013
    Assignee: Seattle Genetics, Inc.
    Inventors: Cheu-leung Law, Alan F. Wahl, Nathalie Scholler, Linda A. Pestano
  • Methods of treating drug-resistant cancers
    Patent number: 8512707
    Abstract: Methods of treating a refractory or drug resistant cancer, cell proliferative disorder and tumor cells are provided.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: August 20, 2013
    Assignee: Seattle Genetics, Inc.
    Inventors: Svetlana O. Doronina, Charles G. Cerveny, Alan F. Wahl
  • Anti-CD70 antibody and its use for the treatment and prevention of cancer and immune disorders
    Patent number: 8337838
    Abstract: Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunomodulatory without conjugation to a therapeutic agents as well as pharmaceutical compositions and kits comprising the antibody or derivative. Also disclosed are methods for the treatment and prevention of CD70-expressing cancers and immunological disorders comprising administering the CD70 binding agents to a subject.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: December 25, 2012
    Assignee: Seattle Genetics, Inc.
    Inventors: Che-Leung Law, Julie McEarchern, Alan F. Wahl
  • Anti-CD70 Antibody and Its Use for the Treatment and Prevention of Cancer and Immune Disorders
    Publication number: 20120294863
    Abstract: Disclosed are CD70 binding agents, such as anti-CD70 antibodies and derivatives, that induce a cytotoxic, cytostatic or immunomodulatory without conjugation to a therapeutic agents as well as pharmaceutical compositions and kits comprising the antibody or derivative. Also disclosed are methods for the treatment and prevention of CD70-expressing cancers and immunological disorders comprising administering the CD70 binding agents to a subject.
    Type: Application
    Filed: August 3, 2012
    Publication date: November 22, 2012
    Applicant: Seattle Genetics, Inc.
    Inventors: Che-Leung Law, Julie McEarchern, Alan F. Wahl
  • Anti-CD70 Antibody-Drug Conjugates and Their Use for the Treatment of Cancer and Immune Disorders
    Publication number: 20120288512
    Abstract: Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.
    Type: Application
    Filed: May 31, 2012
    Publication date: November 15, 2012
    Applicant: Seattle Genetics, Inc.
    Inventors: Che-Leung Law, Alan F. Wahl, Nathalie Scholler, Linda A. Pestano
  • Treatment of B-Cell Cancers With Anti-CD70 Antibody-Drug Conjugates
    Publication number: 20120251559
    Abstract: Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of a CD70-expressing cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
    Type: Application
    Filed: June 7, 2012
    Publication date: October 4, 2012
    Applicant: Seattle Genetics, Inc.
    Inventors: Che-Leung Law, Alan F. Wahl, Nathalie Scholler, Linda A. Pestano
  • THERAPEUTIC COMPOSITIONS AND METHODS
    Publication number: 20120121505
    Abstract: The present application provides novel binding proteins, including human binding proteins that specifically bind to the human ErbB2.
    Type: Application
    Filed: January 12, 2012
    Publication date: May 17, 2012
    Inventors: Davinder Singh Gill, Laird Bloom, Maximillian T. Follettie, Fionnuala McAleese, Sreekumar Kodangattil, John Francis DiJoseph, Nitin K. Damle, Peter R. Baum, Peter A. Thompson, John C. Kumer, Alan F. Wahl, Paul A. Algate, Sateesh Kumar Natarajan
  • Methods for augmenting an immune response using anti-CD40 antibodies
    Patent number: 7824683
    Abstract: The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiates the binding of CD40 to CD40 ligand.
    Type: Grant
    Filed: December 28, 2009
    Date of Patent: November 2, 2010
    Assignee: Seattle Genetics, Inc.
    Inventors: Clay B. Siegall, Alan F. Wahl, Joseph A. Francisco, Henry Perry Fell, Jr.
  • METHODS OF TREATING DRUG-RESISTANT CANCERS
    Publication number: 20100260786
    Abstract: Methods of treating a refractory or drug resistant cancer, cell proliferative disorder and tumor cells are provided.
    Type: Application
    Filed: April 19, 2010
    Publication date: October 14, 2010
    Applicant: Seattle Genetics, Inc.
    Inventors: Svetlana O. Doronina, Charles G. Cerveny, Alan F. Wahl
  • ANTI-CD70 ANTIBODY-DRUG CONJUGATES AND THEIR USE FOR THE TREATMENT OF CANCER AND IMMUNE DISORDERS
    Publication number: 20100183636
    Abstract: Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, immunosuppressive, or other therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing cancers and immunological disorders, comprising administering to a subject the disclosed pharmaceutical compositions.
    Type: Application
    Filed: May 15, 2009
    Publication date: July 22, 2010
    Applicant: Seattle Genetics, Inc.
    Inventors: Che-leung Law, Alan F. Wahl, Nathalie Scholler, Linda A. Pestano
  • TREATMENT OF RENAL CELL CARCINOMA WITH ANTI-CD70 ANTIBODY-DRUG CONJUGATES
    Publication number: 20100158910
    Abstract: Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic, therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of CD70-expressing a cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
    Type: Application
    Filed: December 10, 2009
    Publication date: June 24, 2010
    Applicant: Seattle Genetics, Inc.
    Inventors: Che-Leung Law, Alan F. Wahl, Nathalie Scholler, Linda A. Pestano
  • METHODS FOR AUGMENTING AN IMMUNE RESPONSE USING ANTI-CD40 ANTIBODIES
    Publication number: 20100158906
    Abstract: The present invention relates to methods and compositions for the prevention and treatment of cancer, inflammatory diseases and disorders or deficiencies of the immune system. The methods of the invention comprise administering a CD40 binding protein that potentiates the binding of CD40 to CD40 ligand.
    Type: Application
    Filed: December 28, 2009
    Publication date: June 24, 2010
    Applicant: Seattle Genetics, Inc.
    Inventors: Clay B. Siegall, Alan F. Wahl, Joseph A. Francisco, Henry Perry Fell, JR.
  • TREATMENT OF B-CELL CANCERS WITH ANTI-CD70 ANTIBODY-DRUG CONJUGATES
    Publication number: 20100150925
    Abstract: Disclosed are anti-CD70 antibodies and derivatives thereof conjugated to cytotoxic therapeutic agents, as well as pharmaceutical compositions and kits comprising the antibody- and antibody derivative-drug conjugates. Also disclosed are methods, for the treatment of a CD70-expressing cancer, comprising administering to a subject the disclosed pharmaceutical compositions.
    Type: Application
    Filed: December 10, 2009
    Publication date: June 17, 2010
    Applicant: Seattle Genetics, Inc.
    Inventors: Che-Leung Law, Alan F. Wahl, Nathalie Scholler, Linda A. Pestano