Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for updating a molecular database. In one aspect, a method includes: receiving data representing a sequence of molecular nucleotides, where the data specifies a base of each molecular nucleotide and synthetic modifications to one or more components of one or more molecular nucleotides in the sequence; generating a user interface presentation that presents: i) for each base in the sequence, a base character that represents the base of the molecular nucleotide, and ii) for each of the one or more molecular nucleotides having one or more components that are synthetically modified, a group of symbols adjacent to the base character that represents the base of the molecular nucleotide, where each symbol in the group of symbols represents a respective synthetic modification; and providing the user interface presentation to a user device for display to a user.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for updating a molecular database. In one aspect, a method comprises: receiving a request to update a target molecule component stored in the molecular database; updating the data defining a target molecule represented by the target molecule component; identifying a set of target component links that reference the target molecule component; identifying, for each of the target component links, a respective validation criterion associated with the target component link; determining, for each of the target component links, a new validation status for the target component link by evaluating the validation criterion associated with the target component link; and updating the current validation status of each target component link to the new validation status for the target component link.