Abstract: A set of unsolicited e-mail messages is collected and “finger printed” by either sampling the unsolicited message and using portions of the samples to form the identifier or by hashing a portion of the message. These “finger prints” are used to construct an unsolicited message database. The client's e-mail messages are processed in off-line manner by periodically fetching their messages; “finger printing” each message in a manner identical to the unsolicited messages; checking to see if the “finger print” is in the unsolicited message database; discarding any messages with a “finger print” in the unsolicited message database; and forwarding any message with a “finger print” not in the unsolicited message database to the “clean” POP server.

Abstract: The electronic-to-optical multiplexer takes n electronic inputs Xi where i=0 to n?1; converts Xi into optical signals Yi each with a different wavelength; wavelength multiplexes Yi; samples Yi with an optical frame sync signal having a period of n*p seconds and a pulse width w; wavelength demultiplexes Yi; staggers Yi by i*p seconds; wavelength multiplexes Yi; gates an optical clock signal with Yi; and uses the gated optical clock signal as the optical output. The optical-to-electronic demultiplexer takes n optical sources Zi each with a different wavelength; wavelength multiplexes Zi; gates Zi with the input of the optical-to-electronic demultiplexer; wavelength demultiplexes Zi; staggers Zi by (n?i)*p seconds; wavelength multiplexes Zi; gates Zi with the frame sync signal delayed by (n?1)*p seconds; wavelength demultiplexes Zi; detects Zi with detectors DECTi; and uses the output of DECTi as the electronic outputs.

Abstract: A calendar system including a bound component having a plurality of sheets of paper and a binding mechanism binding the plurality of sheets together. Each sheet includes a calendar portion printed thereon, with each calendar portion of each sheet being of substantially the same size and format. The system further includes a generally translucent insert configured to be directly releasably coupled to the binding mechanism such that the insert is positionable on top of one of the sheets such that the calendar portion of the underlying sheet is visible through the insert. The system includes a permanent writing instrument configured to dispense permanent markings on the insert when the insert is written upon by the writing instrument, and erasing means for erasing permanent markings from the insert.

Abstract: The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.

Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.

Abstract: The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract: A reciprocating and deflecting swing device for the roller of a cylindrical emery-polishing machine includes a motor fixing base having its inner side provided with a lower holder engaged thereon with an upper holder, with an emery-tape roller fitted in the upper holder. A shaft-coupling unit is connected between the shaft of a motor and the emery-tape roller. A speed-reducing device is installed with the motor fixing base, having an input terminal connected to the shaft-coupling unit by a belt. A rod-connecting unit is pivotally provided between the speed-reducing device and the upper holder. Power of the motor is transmitted to the emery-tape roller and the speed-reducing device respectively by the shaft-coupling unit and the belt. The rod-connecting unit is driven to actuate the upper holder and the emery-tape roller to swing to and fro biasly.

Abstract: The invention is related to phosphonate substituted compounds having immuno-modulatory activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract: A reciprocating and deflecting swing device for the roller of a cylindrical emery-polishing machine includes a motor fixing base having its inner side provided with a lower holder engaged thereon with an upper holder, with an emery-tape roller fitted in the upper holder. A shaft-coupling unit is connected between the shaft of a motor and the emery-tape roller. A speed-reducing device is installed with the motor fixing base, having an input terminal connected to the shaft-coupling unit by a belt. A rod-connecting unit is pivotally provided between the speed-reducing device and the upper holder. Power of the motor is transmitted to the emery-tape roller and the speed-reducing device respectively by the shaft-coupling unit and the belt. The rod-connecting unit is driven to actuate the upper holder and the emery-tape roller to swing to and fro biasly.

Abstract: The invention is related to phosphorus substituted nucleoside compounds and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract: The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

Abstract: The present invention provides compounds, compositions and methods for the inhibition or treatment of conditions or disorders modulated by the STAT transcription factors, particularly STAT4 and STAT6. Additionally, the compounds are useful for the diagnosis of conditions dependent on STAT signaling.

Abstract: The present invention provides compounds, compositions and methods for the inhibition or treatment of conditions or disorders modulated by the STAT transcription factors, particularly STAT4 and STAT6. Additionally, the compounds are useful for the diagnosis of conditions dependent on STAT signaling.

Abstract: Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.

Abstract: A keyboard assembly includes an interface facility having a USB plug for coupling to computer facility and an interface switching device coupled to the USB plug. A keyboard facility includes an interface device coupled to the interface facility, an electric power supply device coupled to the interface device to receive electric power from the computer facility, and a keyboard matrix device to detect and send signals of the keyboard assembly to the computer facility. A blue tooth facility is coupled to the interface facility, and includes a signal transforming device and an antenna to receive and send signals.

Abstract: The present invention provides compounds, compositions and methods for the inhibition or treatment of conditions or disorders modulated by the STAT transcription factors, particularly STAT4 and STAT6. Additionally, the compounds are useful for the diagnosis of conditions dependent on STAT signaling.

Abstract: A N input and N output, scalable switching network (80) is implemented with an array of log base x of N rows and N/x columns of routers (40-68); where each router has 2x ports and where the rows of routers are connected to each other via a blocking compensated cyclic group mapping interconnect (49 and 59). A N input and N output, bi-directional scalable switching network (90) is implemented with an array of log base x of (N/2) rows and (N/2)/x columns of routers (40-68); where each router has 2x ports, and where the rows of routers are connected to each other via a blocking compensated cyclic group mapping interconnect (49 and 59). The routers provide destination routing. The levels of blocking compensated cyclic group mapping interconnect provide connectivity between the rows of routers.

Abstract: In a supercomputer that employs a large number of processors operating in parallel, groups of processors are assembled in clusters. Each processor in a cluster is provided with an array of lasers, a different one targeted for a particular detector associated with a specific processor of a different cluster. The detectors associated with the processors in the different cluster are assembled into an array of detectors. A processor wishing to communicate with a processor in a different cluster excites the laser in its associated array that is targeted to the detector of the processor with which it intends to communicate. The patterns of light of the various laser arrays are superimposed into one pattern focused on the detector array by means of an optical tunnel and a spherical lens.

Abstract: A Sagnac gate-based self-routing optical signal switching node demultiplexes each channel of data bits of an N channel multiplexed optical data signal to one of a plurality of output terminals in accordance with the routing bit(s) of each data channel received in the N channel multiplexed optical data signal. In one embodiment, each data channel includes multiple routing bits enabling greater demultiplexer selectivity.

Abstract: An optical communication system includes an optical transmitter which transmits data symbols as pairs of optical pulses having 1) a first predetermined time separation representing a first inputted signal and 2) a second predetermined time separation representing a second inputted signal. The first optical pulse of each pair of pulses may be synchronized to a clock signal of the transmitter. The clock signal operates at a rate which insures that the inter-data symbol spacing is greater than the spacing between the pulses of a symbol pulse pair. The receiver generates a first output signal in response to a pair of pulses having a first predetermined time separation and generates a second output signal in response to a pair of pulses having a second predetermined time separation. The receiver combines the first and second output signal to recover a clock or strobe signal. Sagnac switches are used to implement optical AND circuits utilized in the transmitter and receiver.