Abstract: The combination of: an underground valve for a supply line and having an underground actuator through which a state of the valve can be changed to control flow within the supply line; and a conduit assembly embedded in ground material and defining an access passage through which above ground access can be obtained to the valve actuator. The conduit assembly has an adaptor assembly with a body made from a non-metal material and having at least a first connector. The valve has at least a second connector. The first and second connectors cooperate to maintain the body operatively connected to the valve. A first conduit part is configured to connect to the body and bound a portion of the access passage accessible through an entry opening remote from the valve.

Abstract: The combination of an underground valve, for a supply line and having an underground actuator through which a state of the valve can be changed to control flow within the supply line, and a conduit assembly defining an access passage through which above ground access can be gained to the valve actuator. The conduit assembly further has a cap that can be selectively changed between: a) a first state wherein the cap blocks an entry opening; and b) a second state wherein above ground access can be gained to the valve actuator through the entry opening and access passage. A part of the cap and another part of the conduit assembly interact and are relatively moved as the cap is changed between the first and second states. At least one of: a) the part of the cap; and b) the another part of the conduit assembly is made from a non-metal material.

Abstract: The combination of: a) an underground valve for a supply line and having an underground actuator through which the state of the valve can be changed to control flow within the supply line; and b) a conduit assembly embedded in ground material and defining an access passage through which above ground access can be obtained to the valve actuator. The conduit assembly has a cap that can be selectively changed between: a) a first state wherein the cap blocks the entry opening; and b) a second state wherein above ground access can be gained to the valve actuator. The conduit assembly has an upper conduit part and a lower conduit part. The upper and lower conduit parts are interconnected and configured so that they move axially guidingly against and relative to each other so as to vary an effective combined axial length of the upper and lower conduit parts in response to forces generated by the ground material.

Abstract: A method of repairing an existing conduit assembly embedded in ground material. The conduit assembly has an axial length and defines an access passage through which above ground access can be obtained to an underground valve actuator. The method includes the steps of: removing a portion of the length of the conduit assembly to expose an upper edge defined by a remaining portion of the conduit assembly; providing a repair assembly with a conduit piece having an entry opening; engaging the conduit piece and the remaining portion of the conduit assembly; moving the conduit piece guidingly in an axial direction against the remaining portion of the conduit assembly to thereby situate the entry opening at a desired axial location; and placing a cap on the conduit piece to thereby block the entry opening.

Abstract: The combination of: an underground valve for a supply line and having an underground actuator through which a state of the valve can be changed to control flow within the supply line; and a conduit assembly embedded in ground material and defining an access passage through which above ground access can be obtained to the valve actuator. The conduit assembly has an adaptor assembly with a body made from a non-metal material and having at least a first connector. The valve has at least a second connector. The first and second connectors cooperate to maintain the body operatively connected to the valve. A first conduit part is configured to connect to the body and bound a portion of the access passage accessible through an entry opening remote from the valve.

Abstract: The present invention relates to benzofuro[3,2-c]pyridine and azepine analogs as serotonin sub-type 6 (5-HT6) modulators, pharmaceutical compositions including these compounds, methods of preparation, and use thereof. These compounds are useful in the treatment of central nervous system disorders including obesity, metabolic syndrome, cognition, schizophrenia, attention deficit hyperactivity disorder, bipolar disorder, rare and orphan diseases, and sleep disorders. The subject compounds have the structure of formula (I) with the substituents being described herein.

Abstract: Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described.

Abstract: The present invention relates to epiminocycloalkyl[b]indole derivatives as serotonin sub-type 6 (5-HT6) modulators, pharmaceutical compositions including these compounds, and methods of preparation and use thereof. These compounds are useful in the treatment of central nervous system disorders including obesity, metabolic syndrome, cognition, and schizophrenia. The subject compounds have the structure of formula (I) with the substituents being described herein.

Abstract: The present invention relates to benzofuro[3,2-c]pyridine and azepine analogs as serotonin sub-type 6 (5-HT6) modulators, pharmaceutical compositions including these compounds, methods of preparation, and use thereof. These compounds are useful in the treatment of central nervous system disorders including obesity, metabolic syndrome, cognition, schizophrenia, attention deficit hyperactivity disorder, bipolar disorder, rare and orphan diseases, and sleep disorders. The subject compounds have the structure of formula (I) with the substituents being described herein.

Abstract: The present invention relates to tetrahydro-azacarboline derivatives of formula (I): having the substituents as described herein which are melanin-concentrating hormone (MCH-1) receptor antagonists. The present invention also relates to pharmaceutical compositions including these compounds, and methods of preparation and use thereof.

Abstract: Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.

Abstract: The present invention relates to epiminocycloalkyl[b]indole derivatives as serotonin sub-type 6 (5-HT6) modulators, pharmaceutical compositions including these compounds, and methods of preparation and use thereof. These compounds are useful in the treatment of central nervous system disorders including obesity, metabolic syndrome, cognition, and schizophrenia. The subject compounds have the structure of formula (I) with the substituents being described herein.

Abstract: Methods for using 6-aminoimidazo[1,2-b]pyridazine analogs are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of 6-aminoimidazo[1,2-b]pyridazine analogs, are disclosed herein.

Abstract: Methods for using aminopyrazine analogs to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of aminopyrazine analogs, are also disclosed.

Abstract: Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.

Abstract: A tensioning system for a cleaning blade having a frame, a blade support, and a ratchet system. The blade support is movable around a first axis in a first direction to increase cleaning blade pressure and an opposite second direction. The ratchet system has (a) a first ratchet assembly with at least one ratchet surface facing in a first circumferential direction and (b) a second ratchet assembly having a first plurality of ratchet surfaces facing in a second circumferential direction. At least a part of one of the first and second ratchet assemblies is deformable to allow the blade support to pivot in the first direction to cause the one ratchet surface to (a) move past each of the ratchet surfaces of the blade support moves in the first direction and (b) abut one of the ratchet surfaces to block movement in the second direction.

Abstract: Methods for using 6-aminoimidazo[1,2-b]pyridazine analogs are disclosed herein to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of 6-aminoimidazo[1,2-b]pyridazine analogs, are disclosed herein.

Abstract: The invention relates to nicotinamide derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The nicotinamide derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic, respiratory diseases, disorders and conditions, as well as wounds.

Abstract: The invention relates to nicotinamide derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The nicotinamide derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic, respiratory diseases, disorders and conditions, as well as wounds.

Abstract: The invention relates to nicotinamide derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The nicotinamide derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic, respiratory diseases, disorders and conditions, as well as wounds.