Patents by Inventor Alan J. Mautone
Alan J. Mautone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170151173Abstract: A prophylactic method for preventing otitis media or Eustachian tube dysfunction, or reducing the severity of symptoms thereof, decreasing the risk of future otitis media, with or without ear infection, and associated effects including acute or permanent hearing loss, speech and balance problems, behavior problems and sleep problems caused by acute, intermittent episodic, recurrent or chronic otitis media, and the need for surgical interventions involving myringotomy such as ear tubes for chronic middle ear effusions, or tympanic membrane perforation for acute drainage of effusion from the middle ear and ventilation of the middle ear, through the nasal delivery of surfactant to the Eustachian tube(s).Type: ApplicationFiled: November 30, 2016Publication date: June 1, 2017Applicant: Otic Pharma Inc.Inventors: Gregory J. Flesher, Catherine Crisp Turkel, Alan J. Mautone, Sujana S. Chandrasekhar
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Patent number: 7064132Abstract: A compound, process and method for increasing external auditory canal patency while simultaneously preventing the occurrence of otitis externa is disclosed wherein an aerosolized mixture of lipid crystals comprised of a mixture of one or more lipids surfactants and one or more spreading agents selected from the group consisting of sterols, lipids, fatty acids, cholesteryl esters, phospholipids, carbohydrates, nucleic acids and proteins, in powder form, and one or more fluorocarbon propellants is administered directly to the external auditory canal. Upon administration, the propellant(s) are evaporated from the mixture and the lipid crystals are deposited upon an air/liquid interface resident upon epithelial tissue lining the external auditory canal.Type: GrantFiled: December 11, 2001Date of Patent: June 20, 2006Assignee: Scientific Development and Research, Inc.Inventor: Alan J. Mautone
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Patent number: 6676930Abstract: A process, composition and method for increasing and enhancing mammalian eustachian tube lumen patency and pressure equalization performance is disclosed wherein an aerosolized mixture of lipid crystals comprised of a mixture of one or more lipids surfactants and one or more spreading agents selected from the group consisting of sterols, lipids, fatty acids, cholesteryl esters, phospholipids, carbohydrates, and proteins, in powder form, and one or more propellants, in which the lipid surfactants and spreading agents are not soluble, are administered through a mammalian airway orifice. Upon administration, the propellant(s) are evaporated from the mixture and the lipid crystals are deposited within a subject mammalian eustachian tube whereupon said lipid crystals come into contact with lumen surfaces of the tube forming an amorphous spread film thereupon substantially decreasing the opening pressure of the lumen.Type: GrantFiled: December 4, 2001Date of Patent: January 13, 2004Assignee: Scientific Development and Research, Inc.Inventor: Alan J. Mautone
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Publication number: 20040001868Abstract: A process, composition and method for increasing and enhancing mammalian eustachian tube lumen patency and pressure equalization performance is disclosed wherein an aerosolized mixture of lipid crystals comprised of a mixture of one or more lipids surfactants and one or more spreading agents selected from the group consisting of sterols, lipids, fatty acids, cholesteryl esters, phospholipids, carbohydrates, and proteins, in powder form, and one or more propellants, in which the lipid surfactants and spreading agents are not soluble, are administered through a mammalian airway orifice. Upon administration, the propellant(s) are evaporated from the mixture and the lipid crystals are deposited within a subject mammalian eustachian tube whereupon said lipid crystals come into contact with lumen surfaces of the tube forming an amorphous spread film thereupon substantially decreasing the opening pressure of the lumen.Type: ApplicationFiled: June 27, 2003Publication date: January 1, 2004Inventor: Alan J. Mautone
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Patent number: 6645467Abstract: A composition, process and method is disclosed of decreasing mammalian upper respiratory system airway resistance by administering an aerosolized mixture of lipid crystals comprised of a mixture of one or more lipids surfactants and one or more spreading agents selected from the group consisting of sterols, lipids, fatty acids, cholesteryl esters, phospholipids, carbohydrates, and proteins, in powder form, and one or more propellants, in which the lipid surfactants and spreading agents are not soluble, through a mammalian external airway orifice. Upon administration, the propellant(s) are evaporated from the mixture and the lipid crystals are deposited upon the air/liquid interface resident upon the epithelial lining of the upper respiratory system forming an amorphous spread film thereupon substantially decreasing the resistance to air flow through said upper respiratory system.Type: GrantFiled: December 4, 2001Date of Patent: November 11, 2003Assignee: Scientific Development and Research, Inc.Inventor: Alan J. Mautone
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Patent number: 6616913Abstract: The present invention discloses a method of increasing and enhancing mammalian eustachian tube lumen patency and pressure equalization performance by administering an aerosolized mixture of lipid crystals comprised of a mixture of one or more lipids surfactants and one or more spreading agents selected from the group consisting of cholesteryl esters, phospholipids, carbohydrates, and proteins, in powder form, and one or more fluorocarbon propellants through a mammalian nasal orifice. Upon administration, the propellant(s) are evaporated from the mixture and the lipid crystals are deposited at a subject mammalian eustachian tube whereupon said lipid crystals come into contact with lumen surfaces of the tube forming an amorphous spread film thereupon substantially decreasing the opening pressure of the lumen.Type: GrantFiled: August 16, 2000Date of Patent: September 9, 2003Assignee: Scientific Development and Research, Inc.Inventor: Alan J. Mautone
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Patent number: 6572841Abstract: The present invention discloses a method of decreasing airflow resistance through the mammalian upper respiratory system by administering an aerosolized mixture of lipid crystals comprised of a mixture of one or more lipids surfactants and one or more spreading agents selected from the group consisting of cholesteryl esters, phospholipids, carbohydrates and proteins, in powder form, and one or more fluorocarbon propellants, through nasal or oral inhalation. Upon administration, the propellant(s) are evaporated from the mixture and the lipid crystals are deposited upon the air/liquid interface resident upon epithelial tissue lining air ways and air spaces of said upper respiratory system. Upon contact of said lipid crystals with the air/liquid interface, an amorphous spread film is formed thereupon substantially decreasing the surface tension of said lining and resulting in an increase in volume of said airways and airspaces.Type: GrantFiled: August 16, 2000Date of Patent: June 3, 2003Assignee: Scientific Development and Research, IncInventor: Alan J. Mautone
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Patent number: 6521213Abstract: The present invention discloses a method of increasing external auditory tube patency while simultaneously preventing the occurrence of otitis externa comprising administration of an aerosolized mixture of lipid crystals comprised of a mixture of one or more lipids surfactants and one or more spreading agents selected from the group consisting of cholesteryl esters, phospholipids, carbohydrates, and proteins, in powder form, and one or more fluorocarbon propellants directly to the external auditory tube via the external auditory meatus. Upon administration, the propellant(s) are evaporated from the mixture and the lipid crystals are deposited upon an air/liquid interface resident upon epithelial tissue lining the external auditory tube.Type: GrantFiled: August 16, 2000Date of Patent: February 18, 2003Assignee: Scientific Development and Research, Inc.Inventor: Alan J. Mautone
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Publication number: 20020090344Abstract: A composition, process and method is disclosed of decreasing mammalian upper respiratory system airway resistance by administering an aerosolized mixture of lipid crystals comprised of a mixture of one or more lipids surfactants and one or more spreading agents selected from the group consisting of sterols, lipids, fatty acids, cholesteryl esters, phospholipids, carbohydrates, and proteins, in powder form, and one or more propellants, in which the lipid surfactants and spreading agents are not soluble, through a mammalian external airway orifice. Upon administration, the propellant(s) are evaporated from the mixture and the lipid crystals are deposited upon the air/liquid interface resident upon the epithelial lining of the upper respiratory system forming an amorphous spread film thereupon substantially decreasing the resistance to air flow through said upper respiratory system.Type: ApplicationFiled: December 4, 2001Publication date: July 11, 2002Inventor: Alan J. Mautone
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Publication number: 20020076383Abstract: A compound, process and method for increasing external auditory canal patency while simultaneously preventing the occurrence of otitis externa is disclosed wherein an aerosolized mixture of lipid crystals comprised of a mixture of one or more lipids surfactants and one or more spreading agents selected from the group consisting of sterols, lipids, fatty acids, cholesteryl esters, phospholipids, carbohydrates, nucleic acids and proteins, in powder form, and one or more fluorocarbon propellants is administered directly to the external auditory canal. Upon administration, the propellant(s) are evaporated from the mixture and the lipid crystals are deposited upon an air/liquid interface resident upon epithelial tissue lining the external auditory canal.Type: ApplicationFiled: December 11, 2001Publication date: June 20, 2002Inventor: Alan J. Mautone
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Publication number: 20020064503Abstract: A process, composition and method for increasing and enhancing mammalian eustachian tube lumen patency and pressure equalization performance is disclosed wherein an aerosolized mixture of lipid crystals comprised of a mixture of one or more lipids surfactants and one or more spreading agents selected from the group consisting of sterols, lipids, fatty acids, cholesteryl esters, phospholipids, carbohydrates, and proteins, in powder form, and one or more propellants, in which the lipid surfactants and spreading agents are not soluble, are administered through a mammalian airway orifice. Upon administration, the propellant(s) are evaporated from the mixture and the lipid crystals are deposited within a subject mammalian eustachian tube whereupon said lipid crystals come into contact with lumen surfaces of the tube forming an amorphous spread film thereupon substantially decreasing the opening pressure of the lumen.Type: ApplicationFiled: December 4, 2001Publication date: May 30, 2002Inventor: Alan J. Mautone
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Patent number: 6156294Abstract: The present invention discloses a method of increasing and enhancing mammalian eustachian tube lumen patency and pressure equalization performance by administering an aerosolized mixture of lipid crystals comprised of a mixture of one or more lipids surfactants and one or more spreading agents selected from the group consisting of cholesteryl esters, phospholipids, carbohydrates, and proteins, in powder form, and one or more fluorocarbon propellants through a mammalian nasal orifice. Upon administration, the propellant(s) are evaporated from the mixture and the lipid crystals are deposited at a subject mammalian eustachian tube whereupon said lipid crystals come into contact with lumen surfaces of the tube forming an amorphous spread film thereupon substantially decreasing the opening pressure of the lumen.Type: GrantFiled: November 28, 1999Date of Patent: December 5, 2000Assignee: Scientific Development and Research, Inc.Inventor: Alan J. Mautone
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Patent number: 5306483Abstract: A process to prepare lipid crystalline figures in chloro or hydro fluorocarbon propellants or mixtures thereof for the aerosol delivery of therapeutically active substances which form amorphous films on delivery and which can be suspended in aqueous media to serve as a drug delivery system or, when used without therapeutically active substance, as an artificial tear.Type: GrantFiled: September 4, 1992Date of Patent: April 26, 1994Assignee: Scientific Development & Research, Inc.Inventor: Alan J. Mautone
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Patent number: 5174988Abstract: A process to prepare lipid crystalline figures in fluorocarbon propellants for the delivery of therapeutically active substances which form amorphous films on delivery and which can be suspended in aqueous media to serve as a drug delivery system or, when used without therapeutically active substance, as an artificial tear.Type: GrantFiled: July 27, 1989Date of Patent: December 29, 1992Assignee: Scientific Development & Research, Inc.Inventors: Alan J. Mautone, Joel Klayman