Patents by Inventor Alan John Whitton
Alan John Whitton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8552185Abstract: The present invention relates, inter alia, to a process for preparing a compound of formula (I): using, as a catalyst 1,4-diazabicyclo[2.2.2]octane.Type: GrantFiled: October 2, 2007Date of Patent: October 8, 2013Assignee: Syngenta LimitedInventors: Gillian Beveridge, Ewan Campbell Boyd, Jack Hugh Vass, Alan John Whitton
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Patent number: 8350025Abstract: The present invention relates, inter alia, to a process for preparing a compound of formula (I): using a quinuclidine-based catalyst or an optionally 3-substituted N-methyl pryrrolidine-based catalyst.Type: GrantFiled: October 2, 2007Date of Patent: January 8, 2013Assignee: Syngenta LimitedInventors: Gillan Beveridge, Ewan Campbell Boyd, Jack Hugh Vass, Alan John Whitton
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Patent number: 8124761Abstract: The present invention relates, inter alia, to a process for preparing a compound of formula (I): which comprises either (a) reacting a compound of formula (II): with 2-cyanophenyl, or a salt thereof, in the presence of between 0.1 and 2 mol % of 1,4-diazabicyclo[2.2.2]octane, or (b) reacting a compound of the formula (III): with a compound of the formula (IV): in the presence of between 0.1 and 2 mol % of 1,4-diazabicyclo[2.2.2]octane; where W is the methyl (E)-2-(3-methoxy)acrylate group C(CO2CH3)?CHOCH3 or the methyl 2-(3,3-dimethoxy)propanoate group C(CO2CH3)CH(OCH3)2, or a mixture of the two groups. In addition, the present invention relates to a novel precursors of the compound of formula (I) and methods for making them.Type: GrantFiled: April 13, 2006Date of Patent: February 28, 2012Assignee: Syngenta LimitedInventors: Alan John Whitton, Ewan Campbell Boyd, Jack Vass
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Publication number: 20100063275Abstract: The present invention relates, inter alia, to a process for preparing a compound of formula (I): using a quinuclidine-based catalyst or an optionally 3-substituted N-methyl pryrrolidine-based catalyst.Type: ApplicationFiled: October 2, 2007Publication date: March 11, 2010Applicant: SYNGENTA LIMITEDInventors: Gillan Beveridge, Ewan Campbell Boyd, Jack Hugh Vass, Alan John Whitton
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Publication number: 20100036124Abstract: The present invention relates, inter alia, to a process for preparing a compound of formula (I): using, as a catalyst 1,4-diazabicyclo[2.2.2]octane.Type: ApplicationFiled: October 2, 2007Publication date: February 11, 2010Applicant: SYNGENTA LIMITEDInventors: Gillian Beveridge, Ewan Campbell Boyd, Jack Hugh Vass, Alan john Whitton
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Patent number: 7491834Abstract: 3-Isochromanone is prepared by partially chlorinating o-tolylacetic acid with sulphuryl chloride or chlorine gas in an inert organic solvent in the presence of a free radical initiator. The 2-chloromethylphenylacetic acid first obtained is converted to 3-isochromanone by treatment with a base and separated from unreacted o-tolylacetic acid, which is in the form of a salt, by a phase separation technique. The separated o-tolylacetic acid salt is converted to o-tolylacetic acid by controlled acidification and the o-tolylacetic acid is extracted for re-use. The invention reduces the formation of unwanted, over-chlorinated by-products and leads to a more efficient process.Type: GrantFiled: April 8, 2003Date of Patent: February 17, 2009Assignees: Syngenta Crop Protection, Inc., Syngenta LimitedInventors: Raymond Vincent Heavon Jones, Alan John Whitton, Colin John Bennie, David John Ritchie, Pascal Bugnon
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Publication number: 20080214587Abstract: The present invention relates, inter alia, to a process for preparing a compound of formula (I): which comprises either (a) reacting a compound of formula (II): with 2-cyanophenyl, or a salt thereof, in the presence of between 0.1 and 2 mol % of 1,4-diazabicyclo[2.2.2]octane, or (b) reacting a compound of the formula (III): with a compound of the formula (IV): in the presence of between 0.1 and 2 mol % of 1,4-diazabicyclo[2.2.2]octane; where W is the methyl (E)-2-(3-methoxy)acrylate group C(CO2CH3)?CHOCH3 or the methyl 2-(3,3-dimethoxy)propanoate group C(CO2CH3)CH(OCH3)2, or a mixture of the two groups. In addition, the present invention relates to a novel precursors of the compound of formula (I) and methods for making them.Type: ApplicationFiled: April 13, 2006Publication date: September 4, 2008Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Alan John Whitton, Ewan Campbell Boyd, Jack Vass
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Patent number: 7186839Abstract: A process for extracting from aqueous solution the alkali metal or calcium salt of a halo or haloalkyl substituted 2-hydroxypyridine, or a 2-hydroxyquinoline or 2-hydroxybenzothiazole which comprises contacting an aqueous alkaline or neutral solution of the alkali metal or calcium salt, in which is dissolved an alkali metal fluoride, chloride, bromide, hydroxide, sulphate, sulphite, cyanate, cyanide, thiocyanate, thiosulphate, sulphide, phosphate, hydrogen phosphate, carbonate, bicarbonate, borate, chlorate, hypochlorite, perchlorate, nitrite, chromate, dichromate or permanganate or calcium chloride, bromide, nitrate, nitrite, chlorate, hypochlorite, perchlorate, thiocyanate, thiosulphate, chromate, dichtromate or permanganate, with a partially water-miscible organic solvent so as to transfer aqueous solution of the alkali metal or calcium salt of the 2-hydroxypyridine, 2-hydroxyquinoline or 2-hydroxybenzothiasole into the solvent whilst retaining separate aqueous and solvent phases, and thereafter separatingType: GrantFiled: June 14, 2001Date of Patent: March 6, 2007Assignee: Syngenta LimitedInventors: Raymond Vincent Heavon Jones, Joanne Emma Murray, Jennifer Ann White, Alastair Iain Currie Stewart, Susan Thomson Hamilton, Alan John Whitton, Julie Forrester
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Patent number: 6888008Abstract: A process for the preparation of 3-isochromanone which comprises contacting an o-xylene-?,??-dihalide with carbon monoxide, in the presence of a catalyst and a hindered amine base in a liquid medium comprising water and a tertiary alcohol.Type: GrantFiled: March 16, 2001Date of Patent: May 3, 2005Assignee: Syngenta LimitedInventors: Raymond Vincent Heavon Jones, Alan John Whitton, Jennifer Ann White, David John Ritchie, Robin Fieldhouse, Kirstin Maccormick, Logan Thomson Nisbet, Paul Richard Evans, Colin John Bennie
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Publication number: 20040099609Abstract: A process for extracting from aqueous solution the alkali metal or calcium salt of a halo or haloalkyl substituted 2-hydroxypyridine, or a 2-hydroxyquinoline or 2-hydroxybenzothiazole which comprises contacting an aqueous alkaline or neutral solution of the alkali metal or calcium salt, in which is dissolved an alkali metal fluoride, chloride, bromide, hydroxide, sulphate, sulphite, cyanate, cyanide, thiocyanate, thiosulphate, sulphide, phosphate, hydrogen phosphate, carbonate, bicarbonate, borate, chlorate, hypochlorite, perchlorate, nitrite, chromate, dichromate or permanganate or calcium chloride, bromide, nitrate, nitrite, chlorate, hypochlorite, perchlorate, thiocyanate, thiosulphate, chromate, dichtromate or permanganate, with a partially water-miscible organic solvent so as to transfer aqueous solution of the alkali metal or calcium salt of the 2-hydroxypyridine, 2-hydroxyquinoline or 2-hydroxybenzothiazole into the solvent whilst retaining separate aqueous and solvent phases, and thereafter separatingType: ApplicationFiled: July 14, 2003Publication date: May 27, 2004Inventors: Raymond Vincent Heavon Jones, Joanne Emma Murray, Jennifer Ann White, Alastair Iain Currie Stewart, Susan Thomson Hamilton, Alan John Whitton, Julie Forrester
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Publication number: 20020143193Abstract: A process for the preparation of 3-isochromanone which comprises contacting an o-xylene-&agr;,&agr;′-dihalide with carbon monoxide, in the presence of a catalyst and a hindered amine base in a liquid medium comprising water and a tertiary alcohol.Type: ApplicationFiled: March 16, 2001Publication date: October 3, 2002Inventors: Raymond Vincent Heavon Jones, Alan John Whitton, Jennifer Ann White, David John Ritchie, Robin Fieldhouse, Kirstin Maccormick, Logan Thomson Nisbet, Paul Richard Evans, Colin John Bennie
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Patent number: 6162916Abstract: A process for preparing agrochemical intermediates of formula (I), wherein W is (CH.sub.3 O).sub.2 CH.CHCO.sub.2 CH.sub.3 or CH.sub.3 O.CH.dbd.CCO.sub.2 CH.sub.3 ; Z.sup.1 is a halogen atom; and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen, halogen, C.sub.1-4 alky, C alkoxy, acetoxy or acyl; the process comprising the steps of: (a) reacting a compound of formula (II), wherein X, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined above, with a compound of formula ROCH.sub.3, wherein R is a metal; and, (b) reacting the product of (a) with a compound of formula (III), wherein Z.sup.1 and Z.sup.2 are halogen atoms. A process for the preparation of compounds of formula (II) and compounds of formula (II) themselves. A process for obtaining, in substantially pure form, a compound of formula (11) and compounds of formula (II) themselves. A process for obtaining, in substantially pure form, a compound of formula (11) wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are all hydrogen.Type: GrantFiled: February 16, 1999Date of Patent: December 19, 2000Assignee: Zeneca LimitedInventors: Alan John Whitton, Brian Geoffrey Cox, Gareth Andrew De Boos, Ian Gordon Berry, Ian George Fleming, Raymond Vincent Heavon Jones
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Patent number: 6160117Abstract: 4,6-Dichloropyrimidine is prepared by treating 4,6-dihydroxypyrimidine with a chlorinating agent of the formula R.sup.1 R.sup.2 R.sup.3 PCl.sub.2 wherein R.sup.1, R.sup.2 and R.sup.3 are independently alkyl or aryl, or one or more of the groups R.sup.1, R.sup.2 and R.sup.3 is linked to a polymer support. Conveniently, the chlorinating agent may be prepared in situ by reacting the corresponding phosphine oxide with phosgene. Thus, in a preferred process, 4,6-dichloropyrimidine is prepared by treating 4,6-dihydroxypyrimidine with phosgene in the presence of a phosphine oxide.Type: GrantFiled: November 5, 1998Date of Patent: December 12, 2000Assignee: Zeneca LimitedInventors: Alan John Whitton, Ewan Campbell Boyd, Michael Charles Henry Standen, Peter Karl Wehrenberg, Raymond Vincent Heavon Jones, Timothy John Doyle, David Alan Glanville
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Patent number: 6153750Abstract: A process for preparing (E)-methyl 2-[2-(6-(-cyanophenoxy)pyrimidin-4-yloxy)phenyl]-3-methoxypropenoate comprising contacting (E)-methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxypropenoate or methyl 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3,3-dimethoxypropanoate with 2-cyanophenate anions, the process being conducted in the absence of copper or a copper salt and in the absence of N,N-dimethylformamide. The 2-cyanophenate anions are generated in situ by reacting 2-cyanophenol with an alkali metal carbonate.Type: GrantFiled: June 10, 1999Date of Patent: November 28, 2000Assignee: ZENECA LimitedInventors: Alan John Whitton, Ian George Fleming, Robert Comgall Ewins, Raymond Vincent Heavon Jones, Samuel McNeish
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Patent number: 6143899Abstract: A process for the preparation of 2-hydroxy-6-trifluoromethylpyridine which comprises reacting 2-fluoro-6-trifluomethylpyridine or a mixture of 2-fluoro-6-trifluoromethylpyridine and 2-chloro-6-trifluoromethylpyridine with an alkali metal hydroxide at a temperature of from 50.degree. C. to 160.degree. C. and acidifying the product so formed.Type: GrantFiled: September 3, 1999Date of Patent: November 7, 2000Assignee: Zeneca LimitedInventors: Alexander Pai-Yung Fung, David Dale Friese, Erwin Michael Seidel, Alan John Whitton, Alastair lain Currie Stewart, Jennifer Ann White, Raymond Vincent Heavon Jones, John Desmond Hunt
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Patent number: 6018045Abstract: A process for preparing 4,6-dichloropyrimidine is described, comprising treating 4,6-dihydroxypyrimidine with phosphorus oxychloride in the presence of a saturated hindered amine, the hydrochloride salt of a saturated hindered amine, or an unsaturated 5-membered nitrogen containing ring or a mixture thereof, and, as a first step, directly extracting the 4,6-dichloropyrimidine so formed.Type: GrantFiled: July 17, 1997Date of Patent: January 25, 2000Assignee: Zeneca LimitedInventors: Alan John Whitton, David John Ritchie, Ewan Campbell Boyd, Raymond Vincent Heavon Jones