Abstract: Metal matrix composite articles are made with a substrate and an anodized layer. The anodized layer includes matrix phase and a dispersed phase of reinforcement particles in the matrix, the matrix being an oxide of aluminum or an aluminum alloy. The ratio of the thickness of the anodized layer to the average particle size (D50) of the reinforcement particles is at least 1.3.

Abstract: Rotor, disc, chain ring, and sprocket components are manufactured from a fine particle reinforced metal matrix composite material. The metal matrix composite may be an aluminum or aluminum alloy matrix. The fine reinforcement particles have a particle size from 5 microns to 0.3 microns. These reinforcement particles are dispersed in the matrix.

Abstract: A resonant power converter including synchronous rectifiers adapted to operate with an overlapping conduction phase and a fixed frequency.

Abstract: The present invention relates to a spray device (e.g., an inhaler) comprising an aerosol formulation administered to the respiratory or nasal tract in which the level of formulation remaining in the device can be readily inspected. The device comprises a glass vial (1) coated with a coating of polymeric material having at least one clear or translucent portion (4).

Abstract: A metered dose aerosol actuator, for use in association with a pressurized medicament container provided with a dispensing metering valve having a valve stem, including a housing adapted to receive the container, a stem block extending upwards from the base of the housing and adapted to engage the valve stem by means of a cavity provided in the stem block, the stem block being provided with a spray orifice adapted to be in flow connection with the valve stem and the cavity, a sump extending downwards from the cavity relative to the spray orifice, wherein the sump has a smooth, rounded interior surface.

Abstract: The invention relates to particles for drug delivery by inhalation, said particles incorporating at least one active ingredient which is non-crystalline. The may be a plurality of active ingredients and moreover the outer surface of the particles may be substantially smooth. By providing non-crystalline particles with an outer smooth surface, a substantially accurate dose of active ingredient(s) can, in use of an inhalation device, be delivered each time the device is discharged, with a free flow and non-agglomeration of the particles. This is brought about by the smooth surface and the lack of a periodic ordered structure typical of a crystalline solid. The invention extends to an inhalation composition, and a pulmonary nasal inhalation device including such a composition.

Abstract: A metered dose aerosol actuator, for use in association with a pressurised medicament container (3) provided with a dispensing metering valve having a valve stem (4), comprising a housing (1) adapted to receive the container (3), a stem block (5), extending upwards from the base of the housing (2) and adapted to engage the valve stem (4) by means of a cavity (6) provided in the stem block (5), the stem block being provided with a spray orifice (9) adapted to be in flow connection with the valve stem (4) and the cavity, a sump (8) extending downwards from the cavity (6), relative to the spray orifice (9), wherein the sump (8) has a smooth, rounded interior surface.

Abstract: The present invention relates to a spray device (eg an inhaler) comprising an aerosol formulation administered to the respiratory or nasal tract in which the level of formulation remaining in the device can be readily inspected. The device comprises a glass vial (1) coated with a coating of polymeric material having at least one clear or translucent portion (4).

Abstract: The application discloses an aerosol formulation comprising ?8 Tetrahydrocannabinol for use as a medicine, and the use of ?8 Tetrahydrocannabinol to treat a condition selected from pain, appetite loss, multiple sclerosis and asthma.

Abstract: A formulation for pulmonary or nasal administration comprising a mixture of particles of two or more drugs or excipients produced by spray drying and suitable for administration without further processing of the particles.

Abstract: The present invention relates to a spray device (eg an inhaler) comprising an aerosol formulation administered to the respiratory or nasal tract in which the level of formulation remaining in the device can be readily inspected.