Abstract: This invention provides for compounds of the formula: wherein the variables are defined herein, or salt thereof, compositions comprising these compounds, and method for the treatment, control or prevention of a parasitic infestation or infection in an animal in need thereof by administering an effective amount of these compounds to said animal.

Abstract: Embodiments provide an electric aircraft with a plurality of lift fan assemblies that are configured to provide vertical lift, and one or more pusher propellers that are configured to provide forward thrust. The lift fan assemblies may be coupled to the wings of the aircraft via one or more support structures, and the wings may be coupled to an upper region of the fuselage. The pusher propeller(s) may be coupled to a tailing end of the fuselage. The lift fan assemblies and the pusher propeller(s) may provide thrust and movement in directions that are orthogonal to one another. A control system coupled to the aircraft may control the lift fan assemblies and the one or more pusher propellers to activate, increase in power, and decrease in power. The lift fan assemblies and the one or more pusher propellers may be operated separately, and may be active at different times.

Abstract: A backflow prevention device includes a main pipe body extending along a first center longitudinal axis, at least one check valve disposed within the main pipe body, an inlet pipe connected to an inlet side of the main pipe body, and an outlet pipe connected to an outlet side of the main pipe body. The inlet pipe and the outlet pipe extend along a second center longitudinal axis. The first center longitudinal axis is offset with respect to the second center longitudinal axis in a direction perpendicular to the first and second center longitudinal axes. A center of the valve seat of the at least one check valve is offset with respect to the second center longitudinal axis in the direction perpendicular to the first and second longitudinal axes.

Abstract: The present disclosure describes boron containing pyrimidine compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the present disclosure have activity as Janus kinase (JAK) inhibitors and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described are methods of treating inflammation, auto-immune diseases, cancer, and other conditions that are susceptible to the inhibition of a Janus kinase by administering a compound herein described.

Abstract: This invention provides for compounds of the formula: wherein the variables are defined herein, or salt thereof, compositions comprising these compounds, and method for the treatment, control or prevention of a parasitic infestation or infection in an animal in need thereof by administering an effective amount of these compounds to said animal.

Abstract: Systems, methods, and other embodiments for sorting-based assignment to optimize order fulfillment with short supply. One embodiment includes identifying a set of one or more distributions within a series of days. Sorting all demands of a first priority level occurring in the series of days by ascending order of size of the demand. For each demand of the first priority level in sorted order, (a) selecting an initial distribution during which the demand is scheduled to be fulfilled from the set of distributions, and (b) generating an indication that the demand can cannot be completely fulfilled, based on the size of the demand and the amount of supply available. Automatically arranging a graphical representation of a schedule of supplies and met and unmet demands for the series of days in a graphical user interface based at least on the indications generated for each demand.

Abstract: A system is disclosed to detect failure of a diode that is connected in series with a battery and a contactor or other switch configured to connect the battery to a load when the contactor or other switch is in a closed position and to isolate the battery from the load when the contactor or other switch is in an open position. In various embodiments, the system includes a high value resistor connected between the anode terminal of the diode and ground, the connection to the anode terminal being on a load side of the contactor or other switch; and a voltage meter configured to measure a voltage across the high value resistor at least during a test in which a voltage is applied to a bus associated with the load while the contactor or other switch is in the open position.

Abstract: In some illustrative examples, a bridge suitable for treating a tissue site may include a bridge sealing member and one or more bridge wicking layers. The bridge sealing member may extend along a length of the bridge, and may define an internal passageway in fluid communication between a receiving end of the bridge and a transmitting end of the bridge. The one or more bridge wicking layers may be disposed within the internal passageway of the bridge sealing member. Other apparatus, systems, and methods are disclosed.

Abstract: This disclosure describes devices, systems, and methods related to therapy devices including pumps that are operable in multiple operating modes. An exemplary wound therapy device includes a pump configured to be worn by a user and a controller coupled to the pump and configured to transition the pump from operating in a first operating mode to operating in a second operating mode responsive to a pressure of the wound therapy device satisfying a first pressure threshold. The first operating mode is associated with a first drive voltage that is different from a second drive voltage associated with the second operating mode.

Abstract: A spring stop arrangement for a check valve may include: a check seat defining a flow path; a clapper assembly connected to the check seat and configured to obstruct the flow path, the clapper assembly including: a clapper; and a seal retainer detachably mounted to the clapper; a cam arm connected to the check seat, the cam arm including a stopper; and a torsion spring operatively connected to the cam arm so as to apply a biasing force to the cam arm against the direction of fluid flow. When the seal retainer is dismounted from the clapper, the stopper may be configured to contact the check seat so as to prevent rotation of the cam arm.

Abstract: A check valve may include: a check seat defining a flow path; a clapper assembly hingedly connected to the check seat and configured to obstruct the flow path, including: a clapper and a seal retainer detachably mounted to the clapper; a first extension extending from the clapper assembly in an upstream direction and having a roller; a cam arm rotatable relative to the clapper assembly and configured to engage with the roller; and a torsion spring operatively connected to the cam arm so as to apply a biasing force to the cam arm in the upstream direction. The biasing force may be imparted to the clapper assembly via the cam arm and roller, so that the clapper assembly obstructs the flow path.

Abstract: Electrically powered vehicles with redundant power distribution circuits employ inverters and a multi-phase alternating current (AC) motor. An electrically powered vehicle includes batteries, inverters, interphase transformers, and a three-phase AC motor. Each of the inverters generates a three-phase AC input from power supplied by an associated one of the batteries. The interphase transformers generate drive phases for the AC motor from the three-phase AC inputs generated by the inverters.

Abstract: A power distribution circuit for an electrically powered aircraft includes a plurality of batteries and a plurality of electric propulsion systems. A plurality of power distribution circuits each couple a battery of the plurality of batteries to two or more electric propulsion systems. The plurality of electric propulsion systems are positioned on the aircraft to apply balanced forces to the aircraft such that in the event of a failure, the aircraft remains stable and only experiences a loss in altitude or speed.

Abstract: Embodiments provide a propeller ground stop mechanism configured to keep an unpowered propeller of an aircraft (e.g. when the aircraft is on the ground and not operating) static. The propeller is prevented from rotating due to external forces (e.g. an air flow caused by wind, manual rotation of the propeller). When the propeller is powered, and the propeller is providing thrust, the propeller ground stop mechanism automatically disengages and does not provide any drag. Among various benefits, the propeller ground stop mechanism provides added safety to the ground support personnel.

Abstract: The present invention describes novel boron containing pyrazole compounds, or their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their medical uses. The compounds of the invention have activity as Janus kinase (JAK) inhibitors and are useful in the in the treatment or control of inflammation, auto-immune diseases, cancer, and other disorders and indications where modulation of JAK would be desirable. Also described are methods of treating inflammation, auto-immune diseases, cancer, and other conditions that are susceptible to the inhibition of a Janus kinase by administering a compound herein described.

Abstract: An electrically powered vehicle includes a plurality of batteries and a plurality of DC to DC converters, each coupled to a respective battery of the plurality of batteries. Each DC to DC converter transfers power from a respective battery to a common DC bus. The common DC bus is coupled to a plurality of inverter circuits that convert the DC power to AC power. A plurality of electric motors receive power from the plurality of inverter circuits to propel the vehicle. During a regenerative event, the DC to DC converters can transfer power from the motors back to the batteries. In response to the failure of a battery, the DC to DC converters can isolate the remainder of the system from the failure.

Abstract: A hydraulic radial piston device includes a housing, a pintle having a pintle shaft, a rotor mounted on the pintle shaft and defining a plurality of cylinders, and a plurality of pistons displaceable in the cylinders. The radial piston device further includes a piston ring that provides an interface for the pistons. The radial piston device includes various configurations for improving the performance and efficiency of the device.

Abstract: The present invention relates to cyclopropyl-(hetero)aryl substituted ethylsulphonyl-pyridine derivatives of formula (I) wherein the variables are as defined in the description and in the claims, which can be used as antiparasitic agents for the treatment, prevention and/or control of parasitic infections and/or infestations in animals.

Abstract: This invention provides for compounds of the formula: wherein the variables are defined herein, or a stereoisomer, tautomer, N-oxide, hydrate, solvate, or salt thereof, compositions comprising these compounds, and method for the treatment, control or prevention of a parasitic infestation or infection in an animal in need thereof by administering an effective amount of these compounds to said animal.

Abstract: A power delivery system includes a controller, configured to receive a voltage indication signal indicating a measured voltage of a battery management system and to determine whether first and second diodes of the battery management system are faulty based on the voltage indication signal. The controller is also configured to respectively receive first and second current indication signals from first and second current sensors of the battery management system and to determine whether the first and second diodes of the first battery management system are faulty based on the first and second current indication signals.