Abstract: System and methods for smart cell selection and reselection are described. A mobile device may attempt to camp on a cell in a tracking area that has advertised a particular frequency band. If the mobile device is unable to recognize an information element identifying a different subset of the advertised frequency band than that supported by the mobile device, the mobile device will store a record of the tracking area and the advertised frequency band and compare future cell information broadcasts to the entry, avoiding attempts to operate within cells in the same tracking area advertising the same frequency. In this way the mobile device conserves resources by avoiding actions in incompatible cells and avoids storing information about many cells by only storing the tracking area information.

Abstract: Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.

Abstract: Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.

Abstract: A computing system is provided, including one or more processors configured to provide a social media platform configured to serve a content feed to a user. The processor is further configured to generate user content interaction information by detecting user interactions with the content feed and provide a recommendation engine that selects content items for display in the content feed based on the generated user content interaction information. The processor is further configured to receive a refresh request to refresh the recommendation engine and refresh the recommendation engine at least in part by masking or resetting the user content interaction information upon receiving the refresh request. After the refresh, the processor is further configured to generate, via the recommendation engine, post-refresh content items based on the masked or reset user content interaction information, and transmit the post-refresh content items to the user device for display in the content feed.

Abstract: The invention relates to the targeted delivery of therapeutic molecules to organs, tissues, and cells of humans and other mammals. The invention is directed to a chemical construct for delivering such therapeutic molecules and to methods of making and using the constructs.

Abstract: Compositions and methods for development of potent siRNA therapeutics for prevention and treatment of Corona Virus (2019-nCoV; COVID-19) infections are provided. The compositions include a pharmaceutical composition comprising siRNA cocktails that target critical viral genes and pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers. Administration methods for prevention and treatment are provided, including airway instillation, subcutaneous injections and nebulizer aerosolization.

Abstract: The system and method invention herein disclosed and claimed is a folding skateboard. It can be folded while at rest, on the ground, by applying pressure to one end as the bi-folding deck portions pivot toward one another and come to rest in a fully folded position.

Abstract: The system disclosed and claimed herein is an electric propelling wheel and battery/motor control subsystem enabling the retrofitting of a standard skateboard, having standard truck and wheels, with electrical propulsion capabilities.

Abstract: The system and method invention herein disclosed and claimed is a folding skateboard. It can be folded while at rest, on the ground, by applying pressure to one end as the bi-folding deck portions pivot toward one another and come to rest in a fully folded position.

Abstract: The system and method invention herein disclosed and claimed is a folding skateboard. It can be folded while at rest, on the ground, by applying pressure to one end as the bi-folding deck portions pivot toward one another and come to rest in a fully folded position.

Abstract: Traffic quality on online properties may be assessed continually, and the traffic quality may be used to determine the price of a click-through for an ad placed on the web property. Advertisers bid on keywords, and the bids are used by an advertising engine to place ads on web pages and other online properties. A benchmark price may be set based on the bids. When a user clicks on (or otherwise activates) an ad, the advertiser pays an amount for the click that is based on the benchmark price and on the traffic quality of the property on which the ad had been placed. Machine learning may be used to create a model that predicts traffic quality based on observable feature of a property, thereby allowing the traffic quality of a property to be assessed in real time rather than historically.

Abstract: The present invention relates to a method of manufacturing aseptic tofu using nano- or ultrafiltration. The method includes extracting soy base from soybeans and nano- or ultrafiltering the soy base, thereby concentrating the soy base protein and increasing the total solids of the soy base. The process further includes sterilizing and homogenizing the soy base and finally, mixing the soy base with a coagulant in an aseptic mixing process.