Patents by Inventor Alan M. Kleinfeld

Alan M. Kleinfeld has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and apparatus for ratio fluorometry
    Patent number: 6999173
    Abstract: A method and apparatus for determining the concentration of molecules or atoms by measuring the ratio of two fluorescence signals. A sample having fluorescent molecules is exposed to radiation or excitation energy from a first source, which can be a broadband light source. The fluorescence of the sample is detected at two different wavelengths. The concentration of specific molecules or atoms within the sample is determined using the ratio of the two fluorescence signals. Fluorescent molecules can be bound to a human serum or plasma sample to allow determination of the concentration of unbound free fatty acids in the sample.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: February 14, 2006
    Assignee: FFA Sciences LLC
    Inventors: Alan M. Kleinfeld, Pavel V. Vodkin
  • Method of detecting cardiac ischemia using fatty acid binding protein
    Patent number: 6750030
    Abstract: A method of detecting cardiac ischemia by detecting elevated levels of serum free fatty acids in serum unbound to serum albumin (FFAU) compared to an average FFAU level in individuals without cardiac ischemia, wherein the detection method uses a free fatty acid binding protein derivatized with a fluorescent moiety, is disclosed.
    Type: Grant
    Filed: April 22, 2002
    Date of Patent: June 15, 2004
    Assignee: Torrey Pines Institute for Molecular Studies
    Inventor: Alan M. Kleinfeld
  • Method of detecting cardiac ischemia using fatty acid binding protein
    Publication number: 20020160537
    Abstract: A method of detecting cardiac ischemia by detecting elevated levels of serum free fatty acids in serum unbound to serum albumin (FFAU) compared to an average FFAU level in individuals without cardiac ischemia, wherein the detection method uses a free fatty acid binding protein derivatized with a fluorescent moiety, is disclosed.
    Type: Application
    Filed: April 22, 2002
    Publication date: October 31, 2002
    Inventor: Alan M. Kleinfeld
  • Method of detection of cardiac ischemia using fatty acid binding protein
    Patent number: 6444432
    Abstract: A method of detecting cardiac ischemia by detecting elevated levels of serum free fatty acids in serum unbound to serum albumin (FFAu) compared to an average FAAu level in individuals without cardiac ischemia, wherein the detection method uses a free fatty acid binding protein derivatized with a fluorescent moiety, is disclosed.
    Type: Grant
    Filed: December 8, 1999
    Date of Patent: September 3, 2002
    Inventor: Alan M. Kleinfeld
  • One-step free fatty acid determination method
    Patent number: 5470714
    Abstract: A one reaction step method for determining hydrophobic analytes, such as free hydrophobic analytes, comprising the steps of mixing a solution suspected of containing the hydrophobic analyte, e.g. free fatty acid, with a reagent comprising a fluorescently modified specific-binding protein for the hydrophobic analyte, detecting a fluorescence difference between the fluorescently modified specific-binding protein in the bound and unbound condition, and relating said fluorescence difference to the amount of arialyre in the solution is disclosed.
    Type: Grant
    Filed: November 24, 1993
    Date of Patent: November 28, 1995
    Assignee: Lidak Pharmaceuticals
    Inventor: Alan M. Kleinfeld