Patents by Inventor Alan O. Perantoni

Alan O. Perantoni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDE-BASED STAT INHIBITOR
    Publication number: 20170204148
    Abstract: A peptide or peptidomimetic comprising the amino acid sequence of the second helix of a STAT protein, or a variant of such sequence, wherein the peptide or peptidomimetic comprises about 40 or fewer amino acids and binds to a STAT protein, as well as a method of inhibiting a STAT protein in a cell, a method of treating or preventing a disease associated with STAT overexpression in a host, and related compounds, compositions, and methods.
    Type: Application
    Filed: January 3, 2017
    Publication date: July 20, 2017
    Inventors: Nadya I. Tarasova, Olga Timofeeva, Vadim Gaponenko, Alan O. Perantoni, Sergey G. Tarasov, Christopher J. Michejda
  • Peptide-based stat inhibitor
    Patent number: 9540427
    Abstract: A peptide or peptidomimetic comprising the amino acid sequence of the second helix of a STAT protein, or a variant of such sequence, wherein the peptide or peptidomimetic comprises about 40 or fewer amino acids and binds to a STAT protein, as well as a method of inhibiting a STAT protein in a cell, a method of treating or preventing a disease associated with STAT overexpression in a host, and related compounds, compositions, and methods.
    Type: Grant
    Filed: May 30, 2008
    Date of Patent: January 10, 2017
    Assignee: The United States of America, as represented by the Secretary, Department of Health & Human Services
    Inventors: Nadya I. Tarasova, Olga Timofeeva, Vadim Gaponenko, Christopher J. Michejda, Maria Michejda, Alan O. Perantoni, Sergey G. Tarasov
  • Peptide-based inhibitor of interleukin-10 or interferon-gamma signaling
    Patent number: 9475839
    Abstract: A peptide or peptidomimetic comprising an amino acid sequence based on conserved regions of IL10 or IFN-gamma receptor sequences, and related compounds and compositions, as well as methods for the use thereof to inhibit cytokine signaling.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: October 25, 2016
    Assignee: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Nadya I. Tarasova, Giorgio Trinchieri, Howard A. Young, C. Andrew Stewart, Marco A. Cardone, Alan O. Perantoni
  • Synthetic peptide inhibitors of Wnt pathway
    Patent number: 9056891
    Abstract: A peptide or peptidomimetic comprising the amino acid sequence KKRLSVXLTSSLFR (SEQ ID NO: 1) or the inverse thereof, or comprising at least eight contiguous amino acids of helix C of ?-catenin (SEQ ID NO: 41) or inverse thereof, wherein the peptide or peptidomimetic comprises a total of about 50 or fewer amino acids and inhibits the Wnt pathway, as well as a method of inhibiting the Wnt pathway in a cell, a method of treating or preventing a disease mediated by the Wnt pathway, and related compounds, compositions, and methods.
    Type: Grant
    Filed: June 14, 2013
    Date of Patent: June 16, 2015
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Nadya I. Tarasova, Alan O. Perantoni, Shunsuke Tanigawa
  • SYNTHETIC PEPTIDE INHIBITORS OF WNT PATHWAY
    Publication number: 20130273058
    Abstract: A peptide or peptidomimetic comprising the amino acid sequence KKRLSVXLTSSLFR (SEQ ID NO: 1) or the inverse thereof, or comprising at least eight contiguous amino acids of helix C of ?-catenin (SEQ ID NO: 41) or inverse thereof, wherein the peptide or peptidomimetic comprises a total of about 50 or fewer amino acids and inhibits the Wnt pathway, as well as a method of inhibiting the Wnt pathway in a cell, a method of treating or preventing a disease mediated by the Wnt pathway, and related compounds, compositions, and methods.
    Type: Application
    Filed: June 14, 2013
    Publication date: October 17, 2013
    Inventors: Nadya I. Tarasova, Alan O. Perantoni, Shunsuke Tanigawa
  • PEPTIDE-BASED INHIBITOR OF INTERLEUKIN-10 OR INTERFERON-GAMMA SIGNALING
    Publication number: 20130109619
    Abstract: A peptide or peptidomimetic comprising an amino acid sequence based on conserved regions of IL10 or IFN-gamma receptor sequences, and related compounds and compositions, as well as methods for the use thereof to inhibit cytokine signaling.
    Type: Application
    Filed: May 11, 2011
    Publication date: May 2, 2013
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Nadya I. Tarasova, Giorgio Trinchieri, Howard A. Young, C. Andrew Stewart, Marco A. Cardone, Alan O. Perantoni
  • PEPTIDE-BASED STAT INHIBITOR
    Publication number: 20100184697
    Abstract: A peptide or peptidomimetic comprising the amino acid sequence of the second helix of a STAT protein, or a variant of such sequence, wherein the peptide or peptidomimetic comprises about 40 or fewer amino acids and binds to a STAT protein, as well as a method of inhibiting a STAT protein in a cell, a method of treating or preventing a disease associated with STAT overexpression in a host, and related compounds, compositions, and methods.
    Type: Application
    Filed: May 30, 2008
    Publication date: July 22, 2010
    Applicant: THE U.S OF AMERICA, AS REPRESENTED BY THE SECRETAR
    Inventors: Nadya I. Tarasova, Olga Timofeeva, Vadim Gaponenko, Christopher J. Michejda, Maria Michejda, Alan O. Perantoni, Sergey G. Tarasov