Patents by Inventor Alan Rembaum
Alan Rembaum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4187333Abstract: An ion-exchange hollow fiber is prepared by introducing into the wall of the fiber polymerizable liquid monomers, and polymerizing the monomers therein to form solid, insoluble, cross-linked, ion-exchange resin particles which embed in the wall of the fiber. Excess particles blocking the central passage or bore of the fiber are removed by forcing liquid through the fiber. The fibers have high ion-exchange capacity, a practical wall permeability and good mechanical strength even with very thin wall dimensions. Experimental investigation of bundles of ion-exchange hollow fibers attached to a header assembly have shown the fiber to be very efficient in removing counterions from solution.Type: GrantFiled: March 5, 1975Date of Patent: February 5, 1980Assignee: California Institute of TechnologyInventors: Alan Rembaum, Shiao-Ping S. Yen, Elias Klein
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Patent number: 4170685Abstract: Microspheres are produced by cobalt gamma radiation initiated polymerization of a dilute aqueous vinyl pyridine solution. Addition of cross-linking agent provides higher surface area beads. Addition of monomers such as hydroxyethylmethacrylate acrylamide or methacrylamide increases hydrophilic properties and surface area of the beads. High surface area catalytic supports are formed in the presence of controlled pore glass substrate.Type: GrantFiled: March 22, 1977Date of Patent: October 9, 1979Assignee: California Institute of TechnologyInventors: Alan Rembaum, Amitava Gupta, Willi Volksen
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Patent number: 4157323Abstract: Polymeric functional microspheres containing metal or metal compounds are formed by addition polymerization of a covalently bondable olefinic monomer such as hydroxyethylmethacrylate in the presence of finely divided metal or metal oxide particles, such as iron, gold, platinum or magnetite, which are embedded in the resulting microspheres. The microspheres can be covalently bonded to chemotherapeutic agents, antibodies, or other proteins providing a means for labeling or separating labeled cells. Labeled cells or microspheres can be concentrated at a specific body location such as in the vicinity of a malignant tumor by applying a magnetic field to the location and then introducing the magnetically attractable microspheres or cells into the circulatory system of the subject. Labeled cells can be separated from a cell mixture by applying a predetermined magnetic field to a tube in which the mixture is flowing.Type: GrantFiled: April 20, 1977Date of Patent: June 5, 1979Assignee: California Institute of TechnologyInventors: Shiao-Ping S. Yen, Alan Rembaum, Robert S. Molday
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Patent number: 4138383Abstract: Small, round, bio-compatible microspheres capable of covalently bonding proteins and having a uniform diameter below about 3500 A are prepared by substantially instantaneously initiating polymerization of an aqueous emulsion containing no more than 35% total monomer including an acrylic monomer substituted with a covalently bondable group such a hydroxyl, amino or carboxyl and a minor amount of a cross-linking agent.Type: GrantFiled: November 24, 1975Date of Patent: February 6, 1979Assignee: California Institute of TechnologyInventors: Alan Rembaum, Shiao-Ping S. Yen, William J. Dreyer
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Patent number: 4127506Abstract: Novel polymer supported catalysts are prepared by photo-irradiation of low valent transition metal compounds such as Co.sub.2 (CO).sub.8, Rh.sub.4 (CO).sub.12 or Ru.sub.3 (CO).sub.12 in the presence of solid polymers containing amine ligands such as polyvinyl pyridine. Hydroformylation of olefins to aldehydes at ambient conditions has been demonstrated.Type: GrantFiled: January 31, 1977Date of Patent: November 28, 1978Assignee: California Institute of TechnologyInventors: Harry B. Gray, Alan Rembaum, Amitava Gupta
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Patent number: 4123396Abstract: Amine containing polymeric microspheres such as polyvinyl pyridine are complexed with metal salts or acids containing metals such as gold, platinum or iron. After reduction with sodium borohydride, the salt is reduced to finely divided free metal or metal oxides, useful as catalysts. Microspheres containing covalent bonding sites can be used for labeling or separating proteins.Type: GrantFiled: August 27, 1976Date of Patent: October 31, 1978Assignee: California Institute of TechnologyInventors: Alan Rembaum, Willi Volksen
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Patent number: 4119581Abstract: An ion-exchange membrane is formed from a solution containing dissolved matrix polymer and a set of monomers which are capable of reacting to form a polyquaternary ion-exchange material; for example vinyl pyridine and a dihalo hydrocarbon. After casting the solution and evaporation of the volatile components, a relatively strong ion-exchange membrane is obtained which is capable of removing anions, such as nitrate or chromate from water. The ion-exchange polymer forms an interpenetrating network with the chains of the matrix polymer.Type: GrantFiled: February 23, 1977Date of Patent: October 10, 1978Assignee: California Institute of TechnologyInventors: Alan Rembaum, Carl J. Wallace
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Patent number: 4105598Abstract: Biocompatible polymeric microspheres having an average diameter below about 3 microns and having a density at least 15% greater or lesser than organic cells and having covalent binding sites are provided in accordance with this invention. The microspheres are obtained by copolymerizing a hydroxy or amine substituted acrylic monomer such as hydroxyethylmethacrylate with a light or dense comonomer such as a fluoromonomer. A lectin or antibody is bound to the hydroxy or amine site of the bead to provide cell specificity. When added to a cell suspension the marked bead will specifically label the cell membrane by binding to specific receptor sites thereon. The labelled membrane can then be separated by density gradient centrifugation.Type: GrantFiled: February 3, 1977Date of Patent: August 8, 1978Assignee: California Institute of TechnologyInventors: Shiao-Ping S. Yen, Alan Rembaum, Robert S. Molday
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Patent number: 4102827Abstract: Cationic polyelectrolytes are formed by the polymerization in absence of oxygen of a monomer of the general formula: ##STR1## where x is 3 or more than 6 and Z is I, Br or Cl to form high charge density linear polymers. Segments of the linear polymer may be attached to or formed in the presence of polyfunctional reactive tertiary amines or halogen polymeric substrates or polyfunctional lower molecular reactive polyfunctional substrates to form branched or star polyelectrolytes by a quaternization polymerization reaction.Type: GrantFiled: January 21, 1976Date of Patent: July 25, 1978Assignee: California Institute of TechnologyInventors: Alan Rembaum, Shiao-Ping Siao Yen
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Patent number: 4069365Abstract: Quaternized, cross-linked, insoluble copolymers of unsubstituted and substituted vinyl pyridines and a dihalo organic compound are spontaneously formed at ambient temperature on mixing the two monomers in bulk, in solution or in suspension. The amount of cross-linking may be varied according to the composition and reaction conditions. The polymer product exhibits ion exchange capacity and undergoes a reversible color change from black at a pH above 7 to yellow at a pH below 7. The polymer may be formed in the presence of preformed polymers, substrates such as porous or impervious particles or films to deposit an ion exchange film in situ or on the surface of the substrate. The coated or resin impregnated substrate may be utilized for separation of anionic species from aqueous solution.Type: GrantFiled: June 26, 1973Date of Patent: January 17, 1978Assignee: California Institute of TechnologyInventor: Alan Rembaum
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Patent number: 4061834Abstract: A durable antistatic coating is achieved on polymethylmethacrylate plastic without affecting its optical clarity by applying to the surface of the plastic a low molecular weight solvent having a high electron affinity and a high dipole moment such as acentonitrile or nitromethane alone or in the presence of photopolymerizable monomer. The treated polymethylmethacrylate plastic can then dissipate most of the induced electrostatic charge and retains its optical clarity. The antistatic behavior persists after washing, rubbing and vacuum treatment.Type: GrantFiled: June 3, 1976Date of Patent: December 6, 1977Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Vaclav Hadek, Robert B. Somoano, Alan Rembaum
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Patent number: 4046750Abstract: Linear ionene polyquaternary cationic polymeric segments are bonded by means of the Menshutkin reaction (quaternization) to biocompatible, extremely small, porous particles containing halide or tertiary amine sites which are centers for attachment of the segments. The modified beads in the form of emulsions or suspensions offer a large, positively-charged surface area capable of irreversibly binding polyanions such as heparin, DNA, RNA or bile acids to remove them from solution or of reversibly binding monoanions such as penicillin, pesticides, sex attractants and the like for slow release from the suspension.Type: GrantFiled: September 30, 1974Date of Patent: September 6, 1977Assignee: California Institute of TechnologyInventor: Alan Rembaum
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Patent number: 4046720Abstract: Uniformly-shaped, porous, round beads are prepared by the co-polymerization of an acrylic monomer and a cross-linking agent in the presence of 0.05 to 5% by weight of an aqueous soluble polymer such as polyethylene oxide. Cross-linking proceeds at high temperature above about 50.degree. C or at a lower temperature with irradiation. Beads of even shape and even size distribution of less than 2 micron diameter are formed. The beads will find use as adsorbents in chromatography and as markers for studies of cell surface receptors.Type: GrantFiled: May 30, 1975Date of Patent: September 6, 1977Assignee: California Institute of TechnologyInventors: Alan Rembaum, Shiao-Ping S. Yen, William J. Dreyer
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Patent number: 4045352Abstract: An ion-exchange hollow fiber is prepared by introducing into the wall of the fiber polymerizable liquid monomers, and polymerizing the monomers therein to form solid, insoluble, cross-linked, ion-exchange resin particles which embed in the wall of the fiber. Excess particles blocking the central passage or bore of the fiber are removed by forcing liquid through the fiber. The fibers have high ion-exchange capacity, a practical wall permeability and good mechanical strength even with very thin wall dimensions. Experimental investigation of bundles of ion-exchange hollow fibers attached to a header assembly have shown the fiber to be very efficient in removing counterions from solution.Type: GrantFiled: February 24, 1975Date of Patent: August 30, 1977Assignee: California Institute of TechnologyInventors: Alan Rembaum, Shiao-Ping S. Yen, Elias Klein
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Patent number: 4036808Abstract: Cationic polyelectrolytes formed by the polymerization in absence of oxygen of a monomer of the general formula: dispersed ##STR1## where x is 3 or more than 6 and Z is I, Br or Cl to form high charge density linear polymers are dispered in a water-soluble polymer such as polyvinyl alcohol to form a conductive hydrogel.Type: GrantFiled: December 26, 1973Date of Patent: July 19, 1977Assignee: California Institute of TechnologyInventors: Alan Rembaum, Shiao-Ping Siao Yen
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Patent number: 4035316Abstract: Biocompatible polymeric microspheres having an average diameter below about 3 microns and having density at least 15% greater or lesser than organic cells and having covalent binding sites are provided in accordance with this invention. The microspheres are obtained by copolymerizing a hydroxy or amine substituted acrylic monomer such as hydroxyethylmethacrylate with a light or dense comonomer such as a fluoromonomer. A lectin or antibody is bound to the hydroxy or amine site of the bead to provide cell specificity. When added to a cell suspension the marked bead will specifically label the cell membrane by binding to specific receptor sites thereon. The labelled membrane can then be separated by density gradient centrifugation.Type: GrantFiled: November 24, 1975Date of Patent: July 12, 1977Assignee: California Institute of TechnologyInventors: Shiao-Ping S. Yen, Alan Rembaum, Robert S. Molday
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Patent number: 4014798Abstract: The number of quaternary sites and ion-exchange capacity of a polyquaternary, cross-linked, insoluble copolymer of a vinyl pyridine and a dihalo organic compound is increased by about 15-35% by reaction of the polymer with an amine followed by quaternization, if required. The polymer forms spontaneously in the presence of a substrate such as within the pores of a hollow fiber. The improved resin impregnated fiber may be utilized to remove ions from waste or process streams.Type: GrantFiled: April 4, 1974Date of Patent: March 29, 1977Assignee: California Institute of TechnologyInventor: Alan Rembaum
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Patent number: 4013507Abstract: Ionene polymers of the structure ##STR1## WHERE X AND Y ARE INTEGERS FROM 3 TO 16, Z.sup.- is an anion such as a halogen and n is an integer from 50 to 150 are found to bind negatively charged mammalian cells such as malignant cells and can be utilized to selectively inhibit the growth of malignant cells in vitro.Type: GrantFiled: February 5, 1975Date of Patent: March 22, 1977Assignee: California Institute of TechnologyInventor: Alan Rembaum
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Patent number: 3985632Abstract: Uniformly-shaped, porous, round beads are prepared by the co-polymerization of an acrylic monomer and a cross-linking agent in the presence of 0.05 to 5% by weight of an aqueous soluble polymer such as polyethylene oxide. Cross-linking proceeds at high temperature above about 50.degree.C or at a lower temperature with irradiation. Beads of even shape and even size distribution of less than 2 micron diameter are formed. The beads will find use as adsorbents in chromatography and as markers for studies of cell surface receptors.Type: GrantFiled: October 4, 1974Date of Patent: October 12, 1976Assignee: California Institute of TechnologyInventors: Alan Rembaum, Shiao-Ping Siao Yen, William J. Dreyer
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Patent number: 3957741Abstract: Uniformly-shaped, porous, round beads are prepared by the co-polymerization of an acrylic monomer and a cross-linking agent in the presence of 0.05 to 5% by weight of an aqueous soluble polymer such as polyethylene oxide. Cross-linking proceeds at high temperature above about 50.degree.C or at a lower temperature with irradiation. Beads of even shape and even size distribution of less than 2 micron diameter are formed. The beads will find use as adsorbents in chromatography and as markers for studies of cell surface receptors.Type: GrantFiled: January 17, 1974Date of Patent: May 18, 1976Assignee: California Institute of TechnologyInventors: Alan Rembaum, Shiao-Ping Siao Yen, William J. Dreyer