Abstract: The invention provides a single nucleotide polymorphism (SNP) rs1042714 in the human ADRB2 gene (Gln27Glu) associated with a clinically meaningful reduction in intraocular pressure (IOP) in a human following treatment with a topical beta-blocker. Nucleic acids comprising the SNP are used to screen glaucoma-afflicted individuals to thereby provide an improved method for genotype-based prescribing of beta-blockers in glaucoma management.

Abstract: The invention provides a single nucleotide polymorphism (SNP) rs1042714 in the human ADRB2 gene (Gln27Glu) associated with a clinically meaningful reduction in intraocular pressure (IOP) in a human following treatment with a topical beta-blocker. Nucleic acids comprising the SNP are used to screen glaucoma-afflicted individuals to thereby provide an improved method for genotype-based prescribing of beta-blockers in glaucoma management.

Abstract: An over-center self adjusting cap chuck adapted for operative attachment to a high-speed capping machine includes a housing having an outer peripheral surface defining an inner annular periphery with an interior face. A plurality of independent engagement jaws are aligned along an annular area of, or within a pocket area of, the interior face. Each engagement jaw has a fastener to connect the engagement jaw to the housing and establish a pivot point to support a limited axial rotational movement thereof to a first open axial position and a second closed axial position for receiving and gripping a work piece respectively. Either a singular bias spring or a pair of bias springs pre-dispose the engagement jaws to the first open axial position.

Abstract: An adapter clip for receiving an auxiliary rail having an upper slot and a lower slot, the adapter clip being shaped to be received in a shelf edge having an upper and lower groove. The adapter clip includes an upper flange and a lower flange, the upper and lower flanges being shaped to be received in the upper and lower groove, respectively, to thereby couple the adapter clip to the shelf edge. The adapter clip further includes an upper tang and a lower tang, the upper and lower tangs being shaped to be received in the upper and lower slot, respectively, to thereby couple the adapter clip to the auxiliary rail.

Abstract: An adapter clip for receiving an auxiliary rail having an upper slot and a lower slot, the adapter clip being shaped to be received in a shelf edge having an upper and lower groove. The adapter clip comprises an upper flange and a lower flange, the upper and lower flanges being shaped to be received in the upper and lower groove, respectively, to thereby couple the adapter clip to the shelf edge. The adapter clip further comprises an upper tang and a lower tang, the upper and lower tangs being shaped to be received in the upper and lower slot, respectively, to thereby couple the adapter clip to the auxiliary rail.

Abstract: A presensitized plate adapted for use in lithography comprising a support member with a metal surface, e.g. aluminum metal, and overlying layer containing a diazo compound. In accordance with this invention, the relative exposure sensitivity of the diazo compound is improved by pretreatment to accelerate its reactivity in the presence of actinic light. One method of pretreatment involves preheating the diazo compound to a temperature above about 35.degree. C. up to about 120.degree. C. The improved lithographic plate and the process of preparing plate are claimed.

Abstract: A non-silver, positive-working, essentially alkali-insoluble, radiation-sensitive composition, which becomes alkali-soluble on exposure to radiation, comprising a non-silver, positive-acting, essentially alkali-insoluble radiation-sensitive component a radiation absorbing component and an essentially alkali-soluble polymeric binder. A radiation-sensitive element comprising a transparent substrate overcoated with said radiation-sensitive composition. A duplicating film comprising the said element prepared by exposing said composition through the substrate and then image-wise exposing said composition through a mask in front of the composition followed by treatment with an alkaline developer to remove those areas of the composition subjected to both exposures.

Abstract: An O-epoxyalklyated tetrakis (hydroxyphenyl) alkane resin or the esterified reaction product of about one equivalent thereof with less than one equivalent of an ethylentically unsaturated organic acid can be combined with an aqueous alkali- and radiation sensitive, negative acting substance which when coated on a substrate forms a radiation sensitive negative working element.

Abstract: A method for the production of aluminum substrates useful in the production of lithographic printing plates which comprises first mechanically graining at least one surface of an aluminum sheet to obtain a pumice grained surface of the aluminum sheet, and then electrolytically etching said grained surface with alternating current.

Abstract: An O-epoxyalklyated tetrakis (hydroxyphenyl) alkane resin or the esterified reaction product of about one equivalent thereof with less than one equivalent of an ethylentically unsaturated organic acid can be combined with an aqueous alkali- and radiation sensitive, negative acting substance which when coated on a substrate forms a radiation sensitive negative working element.

Abstract: A colored, positive-acting, radiation-sensitive composition whose color is extinguished or greatly decreased in intensity upon irradiation comprising at least one acid-free resin, at least one component which upon irradiation yields acidic and/or free radical products, at least one acid and/or free radical sensitive dyestuff and at least one positive-acting component; positive-acting elements comprising suitable support materials at least one surface of which has been coated with the above composition and lithographic printing plates comprising the above elements, wherein the support materials are lithographically suitable support materials, whch have been imagewise exposed to radiation whereby there is a high contrast, before development, between the colored image areas and less intensely colored or colorless non-image areas, the image areas of said plates being additionally highly stable against aqueous alkaline developers after development to remove the exposed non-image areas of the composition and more h

Abstract: Described is a lithographic element which may optionally be used as a positive working or a negative working element by minor changes in exposure and development parameters.

Abstract: NEGATIVE WORKING LITHOGRAPHIC PRINTING PLATES WHOSE COATING COMPRISES THE ADMIXTURE OF ACRYLATED ESTERS OF EPOXY RESINS WITH NEGATIVE WORKING LITHOGRAPHIC SENSITIZERS ARE FORMED, WHEREBY THE NON-IMAGE AREAS ARE REMOVABLE BY AQUEOUS ALKALI DEVELOPERS.