Abstract: A method of manufacturing semiconductor arrays is provided. A method of manufacturing semiconductor arrays may comprise applying a functionalization layer to a semiconductor wafer surface, depositing probes on the functionalized semiconductor wafer surface, and processing the printed semiconductor wafer into individual semiconductor arrays. The wafer processing steps and array finishing steps may be performed following functionalization and probe deposition in a manner that preserves the integrity of the probes.

Abstract: Various embodiments provide an improved integrated lab-on-chip apparatus which can perform PCR in one element of the apparatus, and thereafter can detect selected nucleic acids generated in the PCR by electrical addressing and interrogation methods on a microarray portion of the apparatus. Methods of manufacturing the improved integrated lab-on-chip are also provided.

Abstract: A multi-mode, multiplexed array of probe elements of various forms attached to a common support and methods of using the array are disclosed. The array is used for the concurrent and/or sequential detection of combinations of more than one chemical and/or biological material, such as: target nucleic acid sequences, genomic DNA, pcr products, RNA (including microRNA), single nucleotide polymorphisms, proteins, peptides, carbohydrates, polysaccharides, phosphorylation or methylation state of target molecules, chromosomal abnormalities, and other biomolecules, moieties, metals, or chemical compounds in a biological sample.