Patents by Inventor Albert J. J. Van Ooyen

Albert J. J. Van Ooyen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cloning and expression of the exo-polygalacturonase gene from aspergillus
    Patent number: 5624834
    Abstract: The present invention discloses a DNA sequence encoding the exo-polygalacturonase gene form Aspergillus. Specifically the Aspergillus tubigensis exo-polygalacturonase gene is cloned and expressed. The invention relates to vectors comprising the exo-polygalacturonase coding sequence and to host cells transformed with such vectors. The invention further relates to the production of recombinant exo-polygalacturonase and the use of this protein.
    Type: Grant
    Filed: October 17, 1994
    Date of Patent: April 29, 1997
    Assignee: Gist-brocades, B.V.
    Inventors: Margo A. Kusters-Van Someren, Yvonne Muller, Hermanus C. M. Kester, Jacob Visser, Albert J. J. Van Ooyen, Claus Rolin
  • Cloning and expression of xylanase B
    Patent number: 5610046
    Abstract: Method and expression constructs are provided for the cloning of genes from fungal origin which encode polypeptides having the activity of the Aspergillus tubigensis XYL B enzyme and their overexpression in a selected microbial host cell. The present invention provides for the high level production of XYL B which may be used in a variety of industrial applications.
    Type: Grant
    Filed: October 28, 1994
    Date of Patent: March 11, 1997
    Assignee: Gist-brocades, N.V.
    Inventors: Albert J. J. van Ooyen, Leendert H. DeGraaff, Henriette C. van den Broeck, Jacob Visser
  • Cloning and expression of xylanase genes from fungal origin
    Patent number: 5358864
    Abstract: Methods and expression constructs are provided for the cloning and overexpression of xylanases of fungai origin in a selected microbial host cell. Xylanases of fungal origin generally have lower pH optima and remain stable over a broader pH range than do xylanases of bacterial origin. The present invention provides for the high level production of fungal xylanases which are may be used in a variety of industrial applications requiring xylanase activity at a low pH.
    Type: Grant
    Filed: April 27, 1992
    Date of Patent: October 25, 1994
    Assignee: Gist-Brocades, N.V.
    Inventors: Henriette C. van den Broeck, Leendert H. de Graaff, Jan D. R. Hille, Albert J. J. van Ooyen, Jacob Visser, Abraham Harder
  • Proteins with factor VIII activity: process for their preparation using genetically-engineered cells and pharmaceutical compositions containing them
    Patent number: 5171844
    Abstract: Novel polypeptides having Factor VIII activity are provided as well as compositions and methods for their preparation. The polypeptides comprise derivatives and fragments of Factor VIII and have sequences substantially similar to portions of naturally occuring Factor VIII. The polypeptides find use in treatment of Hemophilia A.
    Type: Grant
    Filed: June 10, 1988
    Date of Patent: December 15, 1992
    Assignee: Gist-Brocades N.W.
    Inventors: Albert J. J. van Ooyen, Hans Pannekoek, Martinus P. Verbeet, Robert W. van Leen
  • Kluyveromyces as a host strain
    Patent number: 4943529
    Abstract: Kluyveromyces hosts and DNA expression cassettes for use in Kluyveromyces are provided for transcription of endogenous and/or exogenous DNA, and production of peptides, for enhancing production of an endogenous product, or producing an exogenous product. The Kluyveromyces hosts find particular use for secretion of a desired peptide product, where signal sequences may be native to the peptide or provided from endogenous or exogenous signal sequences, including synthetic sequences, functional in Kluyveromyces. A transformation procedure is provided for efficiently transforming Kluyveromyces.
    Type: Grant
    Filed: July 28, 1987
    Date of Patent: July 24, 1990
    Assignee: Gist-brocades NV
    Inventors: Johan A. Van den Berg, Albert J. J. Van Ooyen, Krijn Rietveld