Patents by Inventor Albert L. Lu
Albert L. Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11959085Abstract: The present disclosure provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for regulatory elements from Lamium Leaf Distortion Associated Virus. A method for expressing a heterologous nucleotide sequence in a plant using the regulatory element sequences disclosed herein is provided. The method comprises transforming a plant or plant cell with a nucleotide sequence operably linked to one of the regulatory elements of the present disclosure.Type: GrantFiled: February 21, 2020Date of Patent: April 16, 2024Assignees: PIONEER HI-BRED INTERNATIONAL, INC., CORTEVA AGRISCIENCE LLCInventors: Scott Diehn, Michelle Van Allen, Albert L Lu
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Publication number: 20230408426Abstract: The present embodiments generally relate to methods of non-destructively imaging plant root damage by insect root herbivores and evaluating the efficacy of insecticidal materials associated with the roots of plants against the insect root herbivores, useful for automated high throughput bioassays.Type: ApplicationFiled: June 1, 2023Publication date: December 21, 2023Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: DENNY JOSEPH BRUCK, KALEY J GADE, ALBERT L LU, TIMOTHY MICHAEL MORIARTY, ANGEL O ORTIZ LOZADA, GARY A SANDAHL, GERARDUS W A M VAN DER HEIJDEN
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Publication number: 20230348930Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: June 29, 2023Publication date: November 2, 2023Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: JENNIFER KARA BARRY, ANGEL ELIZABETH GRACE D′OLIVIERA, RYAN MICHAEL GERBER, KEVIN HAYES, ALBERT L LU, AMY LUM, UTE SCHELLENBERGER, ERIC SCHEPERS, JEFFREY SOPA, WEIPING XIE, NASSER YALPANI
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Publication number: 20230340522Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: January 25, 2023Publication date: October 26, 2023Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: NURIA JIMENEZ-JUAREZ, ALBERT L LU, LU LIU, MARK EDWARD NELSON, GUSUI WU
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Publication number: 20230272018Abstract: The disclosure provides nucleic acids, and variants and fragments thereof, derived from strains of Bacillus thuringiensis encoding variant polypeptides having increased pesticidal activity against insect pests, including Lepidoptera and Coleopteran. Particular embodiments of the disclosure provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.Type: ApplicationFiled: October 17, 2022Publication date: August 31, 2023Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: ALBERT L. LU, MARK EDWARD NELSON, GUSUI WU, TAKASHI YAMAMOTO
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Patent number: 11739344Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.Type: GrantFiled: June 14, 2018Date of Patent: August 29, 2023Inventors: Jennifer Kara Barry, Angel Elizabeth Grace D'Oliviera, Ryan Michael Gerber, Kevin Hayes, Albert L Lu, Amy Lum, Ute Schellenberger, Eric Schepers, Jeffrey Sopa, Weiping Xie, Nasser Yalpani
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Publication number: 20230227843Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: January 31, 2023Publication date: July 20, 2023Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: ALBERT L LU, KNUT MEYER, GILDA RAUSCHER, GUSUI WU
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Patent number: 11703463Abstract: The present embodiments generally relate to methods of non-destructively imaging plant root damage by insect root herbivores and evaluating the efficacy of insecticidal materials associated with the roots of plants against the insect root herbivores, useful for automated high throughput bioassays.Type: GrantFiled: April 19, 2022Date of Patent: July 18, 2023Assignee: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: Denny Joseph Bruck, Kaley J Gade, Albert L Lu, Timothy Michael Moriarty, Angel O Ortiz Lozada, Gary A Sandahl, Gerardus W A M Van Der Heijden
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Publication number: 20230210079Abstract: Embodiments disclosed herein relate to the field of plant molecular biology, specifically to DNA constructs for conferring insect resistance to a plant.Type: ApplicationFiled: May 11, 2021Publication date: July 6, 2023Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: HEATHER MARIE CHRISTENSEN, BIN CONG, VIRGINIA CRANE, MATTHEW CURTIS HARMON, LUCIANO M JAUREGUY, JEFFREY KLEVER, ALBERT L. LU, KRISTEN DENISE RINEHART KREBS, MARGIT C ROSS
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Publication number: 20230200335Abstract: Embodiments disclosed herein relate to the field of plant molecular biology, specifically to DNA constructs for conferring insect resistance to a plant. Embodiments disclosed herein relate to insect resistant corn plant containing event DP-910521-2, and to assays for detecting the presence of event DP-910521-2 in samples and compositions thereof.Type: ApplicationFiled: November 14, 2022Publication date: June 29, 2023Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: BIN CONG, VIRGINIA CRANE, ALBERT L. Lu, JASDEEP S. MUTTI, M. ALEJANDRA PASCUAL, KRISTEN DENISE RINEHART KREBS, MARIA MAGDALENA VAN DYK, JIAMING YIN
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Patent number: 11627742Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Coleopteran plant pest or a Diabarotica plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-236 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is D. virgifera virgifera, D. barberi, D. speciosa, or D. undecimpunctata howardi.Type: GrantFiled: March 2, 2020Date of Patent: April 18, 2023Assignee: CORTEVA AGRISCIENCE LLCInventors: Karen E Broglie, Kevin Andrew Kriss, Albert L Lu, Mani Muthalagi, James Kevin Presnail
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Publication number: 20220307993Abstract: The present embodiments generally relate to methods of non-destructively imaging plant root damage by insect root herbivores and evaluating the efficacy of insecticidal materials associated with the roots of plants against the insect root herbivores, useful for automated high throughput bioassays.Type: ApplicationFiled: April 19, 2022Publication date: September 29, 2022Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: DENNY JOSEPH BRUCK, KALEY J GADE, ALBERT L LU, TIMOTHY MICHAEL MORIARTY, ANGEL O ORTIZ LOZADA, GARY A SANDAHL, GERARDUS W A M VAN DER HEIJDEN
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Publication number: 20220267792Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a plant insect pest, such as Coleopteran, Hemiptera, or Lepidopteran plant pest, including a Diabrotica, Leptinotarsa, Phyllotreta, Acyrthosiphan, Bemisia, Halyomorpha, Nezara, or Spodoptera plant pest, decrease the expression of a target sequence in the pest. Disclosed are various target polynucleotides set forth in any one of SEQ ID NOS: 1-53 or 107-254 disclosed herein, or variants and fragments thereof, or complements thereof, wherein a decrease in expression of one or more of the sequences in the target pest controls the pest and pest population by insect sterilization (i.e., male and female sterility, reduction of sperm count, egg production and viability) and mating-based sterile insect technique (SIT). Plants, plant parts, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.Type: ApplicationFiled: April 29, 2022Publication date: August 25, 2022Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANYInventors: XU HU, BLISS MARIE KERNODLE, MOLLIE MARY MCMAHON, ADANE KASSA, XIPING NIU, JAMES KEVIN PRESNAIL, ALBERT L. LU, NINA RICHTMAN, JONATHAN WILLIAM ROBESON
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Patent number: 11333618Abstract: The present embodiments generally relate to methods of non-destructively imaging plant root damage by insect root herbivores and evaluating the efficacy of insecticidal materials associated with the roots of plants against the insect root herbivores, useful for automated high throughput bioassays.Type: GrantFiled: June 4, 2020Date of Patent: May 17, 2022Inventors: Denny Joseph Bruck, Kaley J. Gade, Albert L. Lu, Timothy Michael Moriarty, Angel O. Ortiz Lozada, Gary A. Sandahl, Gerardus W. A. M. Van Der Heijden
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Publication number: 20220002821Abstract: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-004114-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.Type: ApplicationFiled: September 9, 2021Publication date: January 6, 2022Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANYInventors: SCOTT DIEHN, ALBERT L LU, TIMOTHY M NOWATZKI, DOUGLAS S NUBEL, M ALEJANDRA PASCUAL, JAMES C REGISTER, III, CHRISTOPHER J SCELONGE, JOSHUA K YOUNG, CATHY XIAOYAN ZHONG, ERIN L CROWGEY
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Publication number: 20210381000Abstract: Embodiments disclosed herein relate to the field of plant molecular biology, specifically to DNA constructs for conferring insect resistance to a plant. Embodiments disclosed herein relate to insect resistant corn plant containing event DP-915635-4, and to assays for detecting the presence of event DP-915635-4 in samples and compositions thereof.Type: ApplicationFiled: May 27, 2021Publication date: December 9, 2021Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: HEATHER MARIE CHRISTENSEN, BIN CONG, VIRGINIA CRANE, MATTHEW CURTIS HARMON, LUCIANO M JAUREGUY, JEFFREY KLEVER, ALBERT L LU, KRISTEN DENISE RINEHART KREBS, MARGIT C ROSS
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Patent number: 11155883Abstract: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-004114-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.Type: GrantFiled: January 14, 2019Date of Patent: October 26, 2021Inventors: Scott Diehn, Albert L Lu, Timothy M Nowatzki, Douglas S Nubel, M Alejandra Pascual, James C Register, III, Christopher J Scelonge, Joshua K Young, Cathy Xiaoyan Zhong, Erin L Crowgey
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Publication number: 20210321626Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Coleopteran plant pest or a Diabrotica plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-236 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is D. virgifera virgifera, D. barberi, D. speciosa, or D.Type: ApplicationFiled: April 17, 2021Publication date: October 21, 2021Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: KAREN E BROGLIE, KEVIN ANDREW KRISS, ALBERT L LU, MANI MUTHALAGI, JAMES KEVIN PRESNAIL
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Patent number: 11028407Abstract: The disclosure provides nucleic acids, and variants and fragments thereof, derived from strains of Bacillus thuringiensis encoding variant polypeptides having increased pesticidal activity against insect pests, including Lepidoptera and Coleopteran. Particular embodiments of the disclosure provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.Type: GrantFiled: April 19, 2017Date of Patent: June 8, 2021Inventors: Albert L Lu, Gusui Wu
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Publication number: 20210092961Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: June 14, 2018Publication date: April 1, 2021Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: JENNIFER KARA BARRY, ANGEL ELIZABETH GRACE D'OLIVIERA, RYAN MICHAEL GERBER, KEVIN HAYES, ALBERT L LU, AMY LUM, UTE SCHELLENBERGER, ERIC SCHEPERS, JEFFREY SOPA, WEIPING XIE, NASSER YALPANI