Patents by Inventor Albert Martinus Van der Sloot

Albert Martinus Van der Sloot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VARIANTS OF THE TNF SUPERFAMILY AND USES THEREOF
    Publication number: 20140178329
    Abstract: Described are novel variants of APRIL that modulate signaling via receptor-specific agonist activity, and nucleic acids encoding these variant proteins. Further described is the use of these novel proteins in the treatment of APRIL-associated disorders, in particular, pathologies of the immune system and oncological disorders.
    Type: Application
    Filed: December 13, 2013
    Publication date: June 26, 2014
    Applicants: Institucio Catalana de Recerca I Estudis Avancats (ICREA), Fundacio Privada Centre de Regulacio Genomica (CRG)
    Inventors: Luis Serrano Pubul, Albert Martinus Van Der Sloot, Jan Paul Medema, Fiona Clare Kimberley
  • TNF Family Ligand Variants
    Publication number: 20140096274
    Abstract: The present invention relates to variants of TNF family ligands which have been mutated at the ligand trimerisation interface so that they are not capable of assembling into trimers, and either assemble into dimers or remain as monomers. Such ligands bind to the TNF receptor but are unable to activate it, effectively functioning as competitive inhibitors. The invention also relates to nucleic acids encoding the variants of TNF family ligands, vectors and host cells comprising the nucleic acid and methods for the treatment of diseases associated with aberrant signalling through a TNF receptor.
    Type: Application
    Filed: December 23, 2011
    Publication date: April 3, 2014
    Inventors: Wilhelmus Johannes Quax, Vicente R. Tur, Luis Serrano, Albert Martinus Van Der Sloot, Robbert H. Cool, Aart H.G. Van Assen
  • CYTOKINE DESIGN
    Publication number: 20110200552
    Abstract: The present invention relates to novel cytokines, which have a modified selectivity/specificity for their cognate receptors. In particular, the invention relates to a variant TRAIL protein, which has superior selectivity for the death receptor 4 (TRAIL-RI) over the death receptor 5 (TRAIL-R2). In addition, the invention relates to a variant TRAIL protein which exhibits superior selectivity for the death receptor 4 (TRAIL-R1) over the decoy receptors DcR1 (TRAIL-R3) and DcR2 (TRAIL-R4).
    Type: Application
    Filed: November 21, 2008
    Publication date: August 18, 2011
    Applicants: RIJKSUNIVERSITEIT GRONINGEN, NATIONAL UNIVERSITY OF IRELAND, GALWAY, TRISKEL THERAPEUTICS B.V, Fundacio Privada Centre De Regulacio Genomica (CRG), Institucio Catalana De Recerca I Estudis Avancats (ICREA)
    Inventors: Carlos Ricardo Rodrigues Dos Reis, Wilhelmus Johannes Quax, Afshin Samali, Eva Szegezdi, Robbert Hans Cool, Albert Martinus Van Der Sloot, Luis Serrano, Vicente Tur
  • Cytokine design
    Patent number: 7994281
    Abstract: The present invention relates to novel methods for the design of proteins, in particular, cytokines. These methods allow the stabilisation of such cytokines, as well as modification of their selectivity/specificity for their cognate receptors. The invention also relates to various modified proteins that have been designed by the methods of the invention.
    Type: Grant
    Filed: December 6, 2004
    Date of Patent: August 9, 2011
    Assignees: European Molecular Biology Laboratory, National University of Ireland, University of Groningen
    Inventors: Vicente R. Tur, Albert Martinus Van der Sloot, Margaret M. Mullally, Robbert H. Cool, Eva E. Szegezdi, Afshin Samali, Gregorio Fernandez-Ballester, Luis Serrano, Wilhelmus J. Quax
  • Cytokine Design
    Publication number: 20080044376
    Abstract: The present invention relates to novel methods for the design of proteins, in particular, cytokines. These methods allow the stabilisation of such cytokines, as well as modification of their selectivity/specificity for their cognate receptors. The invention also relates to various modified proteins that have been designed by the methods of the invention.
    Type: Application
    Filed: December 6, 2004
    Publication date: February 21, 2008
    Inventors: Vicente R. Tur, Albert Martinus Van der Sloot, Margaret M. Mullally, Robbert H. Cool, Eva E. Szegezdi, Afshin Samali, Gregorio Fernandez-Ballester, Luis Serrano, Wilhelmus J. Ouax