Abstract: This invention relates to certain polyamine derivatives, to the methods and intermediates useful for their preparation, and to their use in treating diseases caused by infestation with a variety of parasitic protozoa.

Abstract: Drug-resistant malarial infection in humans can be effectively treated with standard antimalarial agents if administered in conjunction with desipramine.

Abstract: Red blood cells which are infected with the parasite P. falciparum cause the cells to become sticky and less deformable. This results in a build-up of cells on the vascular wall and creates occlusions to blood flow which are thought to cause the cerebral, renal and liver complications of P. falciparum infections. Certain esters of castanospermine prevent or reduce the adhesion of falciparum infected blood cells to the vascular endothelial wall and are a useful adjunct in the treatment of malaria.

Abstract: This invention relates to the use of .alpha.- halomethyl, .alpha.-acetylenic or .alpha.-allenic derivatives of arginine and agmatine, or their dehydro analogs, in the treatment of Chagas disease and Coccidiosis.

Abstract: The use of lofexidine and its pharmaceutically acceptable salts in alleviating the adverse symptoms of drug withdrawal, pre-menstrual tension and peri-menopausal flushing is disclosed.

Abstract: The use of lofexidine and its pharmaceutically acceptable salts in alleviating the adverse symptoms of drug withdrawal, pre-menstrual tension and peri-menopausal flushing is disclosed.

Abstract: The use of lofexidine and its pharmaceutically acceptable salts in alleviating the adverse symptoms of tobacco withdrawal is disclosed.

Abstract: .alpha.-Substituted amines are described which are useful in controlling the growth of algae.

Abstract: Fluorinated diaminobutane compounds in vivo are inhibitors of gamma-aminobutyric acid transaminase and have the following formula: ##STR1## wherein: R.sub.1 represents hydrogen, C.sub.1 -C.sub.6 alkyl, or phenyl-(C.sub.1 -C.sub.4 alkyl);R.sub.2 represents hydrogen, C.sub.1 -C.sub.6 alkyl, phenyl-(C.sub.1 -C.sub.4 alkyl), or R.sub.4, where R.sub.4 is as defined below;R.sub.3 represents hydrogen, or, except when R.sub.2 represents R.sub.4, R.sub.4, where R.sub.4 is as defined below;each R.sub.4, independently, represents C.sub.2 -C.sub.5 alkylcarbonyl, phenylcarbonyl, phenyl-(C.sub.1 -C.sub.4 alkyl) carbonyl, or an aminocarboxylic acid residue derived by removal of an hydroxy group from the carboxy moiety of an L-aminocarboxylic acid; andp represents 1 or 2,and pharmaceutically acceptable acid addition salts thereof.

Abstract: .alpha.-Substituted amines and .alpha.-substituted-.alpha.-amino acids are described which are useful in inhibiting the growth of protozoa in animals.

Abstract: The use of lofexidine and its pharmaceutically acceptable salts in alleviating the adverse symptoms of drug withdrawal is disclosed.

Abstract: .alpha.-Substituted amines and .alpha.-substituted-.alpha.-amino acids are described which are useful in controlling the growth of algae.

Abstract: Therapeutic antihypertensive compositions containing N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine and N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine or their non-toxic, pharmaceutically acceptable salts are described as well as a method of reducing blood pressure in mammals.

Abstract: Therapeutic antihypertensive compositions containing 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole and N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine or their non-toxic, pharmaceutically acceptable salts are described as well as a method of reducing blood pressure in mammals.