Patents by Inventor Albert Zorko Abram
Albert Zorko Abram has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9827195Abstract: The present invention provides a foamable composition comprising water and an organic solvent, wherein the organic solvent comprises a fatty acid. The composition may further comprise a pharmaceutically active agent. The composition of the invention is also useful for the treatment of a dermatological disorder in a mammal by the topical administration of the composition.Type: GrantFiled: April 10, 2015Date of Patent: November 28, 2017Assignee: STIEFEL RESEARCH AUSTRALIA PTY LTDInventors: Albert Zorko Abram, Iulian Goldstein
-
Patent number: 9492384Abstract: An oil in water microemulsion or sub-micron emulsion composition for dermal delivery of desonide is provided, along with a method of medical or cosmetic treatment of a dermal condition using the composition. The composition includes desonide; an oil phase dispersed throughout a water phase, the oil phase including at least one member selected from the group consisting of an animal oil, a mineral oil, a vegetable oil, a silane member, a siloxane, an ester, a fatty acid, a fat, a halogen compound, and an alkoxylated alcohol; and at least one lipophilic surfactant, the water phase including at least one hydrophilic surfactant and water; and a non-surfactant amphiphilic compound that is miscible in the water phase and added to the composition after formation of the microemulsion or sub-micron emulsion; wherein the desonide is in the water phase or both the water phase and the oil phase.Type: GrantFiled: February 24, 2015Date of Patent: November 15, 2016Assignee: STIEFEL WEST COAST LLCInventors: Maria Graziella Larm, Ronald Harding, Michael Johnston, Albert Zorko Abram, Prema Viyayakumar, Phoebe Sun
-
Patent number: 9486394Abstract: The present invention provides various pharmaceutically active topical delivery compositions. In particular, compositions of the present invention are present in a pressurized container comprising a quick-breaking alcoholic foaming agent, such that when the composition is released, i.e., dispensed, from the pressurized container, a quick-breaking temperature sensitive foam is formed. In addition, the present invention provides various aspects related to such compositions, including methods for modulating a foam characteristic, methods for improving the shelf-life of a pharmaceutically active compound, methods for the percutaneous treatment of various diseases, infections, and illnesses, and methods for evaluating foam characteristics.Type: GrantFiled: October 14, 2013Date of Patent: November 8, 2016Assignee: STIEFEL WEST COAST, LLCInventors: Albert Zorko Abram, Lilian Fuchshuber
-
Patent number: 9265726Abstract: The present subject matter provides foamable suspension gels that foam after release from a container. The foamable suspension gels contain at least one pharmaceutically active agent that is sparingly soluble to insoluble in water, a second pharmaceutically active agent, and optionally a third active agent.Type: GrantFiled: May 12, 2014Date of Patent: February 23, 2016Assignee: STIEFEL RESEARCH AUSTRALIA PTY LTDInventors: Albert Zorko Abram, Lilian Fuchshuber
-
Publication number: 20150258023Abstract: An oil in water microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, is provided. The composition includes an oil phase dispersed throughout a water phase, the oil phase including at least one member selected from the group consisting of an animal oil, a mineral oil, a vegetable oil, a silane member, a siloxane, an ester, a fatty acid, a fat, a halogen compound, and an alkoxylated alcohol; and at least one lipophilic surfactant, the water phase including at least one hydrophilic surfactant, water and optionally a non-surfactant amphiphilic compound, the weight ratio of the at least one hydrophilic surfactant to the at least one lipophilic surfactant being approximately 9.0:1.0 to 2.0:3.0.Type: ApplicationFiled: February 24, 2015Publication date: September 17, 2015Inventors: Maria Graziella LARM, Ronald HARDING, Michael JOHNSTON, Albert Zorko ABRAM, Prema VIYAYAKUMAR, Phoebe SUN
-
Publication number: 20150209280Abstract: The present invention provides a foamable composition comprising water and an organic solvent, wherein the organic solvent comprises a fatty acid. The composition may further comprise a pharmaceutically active agent. The composition of the invention is also useful for the treatment of a dermatological disorder in a mammal by the topical administration of the composition.Type: ApplicationFiled: April 10, 2015Publication date: July 30, 2015Inventors: Albert Zorko ABRAM, Iulian GOLDSTEIN
-
Patent number: 9023863Abstract: The present invention provides a foamable composition comprising water and an organic solvent, wherein the organic solvent comprises a fatty acid. The composition may further comprise a pharmaceutically active agent. The composition of the invention is also useful for the treatment of a dermatological disorder in a mammal by the topical administration of the composition.Type: GrantFiled: July 12, 2007Date of Patent: May 5, 2015Assignee: Stiefel Research Australia Pty LtdInventors: Albert Zorko Abram, Iulian Goldstein
-
Patent number: 8962000Abstract: An oil in water microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, is provided. The composition includes an oil phase dispersed throughout a water phase, the oil phase including at least one member selected from the group consisting of an animal oil, a mineral oil, a vegetable oil, a silane member, a siloxane, an ester, a fatty acid, a fat, a halogen compound, and an alkoxylated alcohol; and at least one lipophilic surfactant, the water phase including at least one hydrophilic surfactant, water and optionally a non-surfactant amphiphilic compound, the weight ratio of the at least one hydrophilic surfactant to the at least one lipophilic surfactant being approximately 9.0:1.0 to 2.0:3.0.Type: GrantFiled: April 30, 2013Date of Patent: February 24, 2015Assignee: Stiefel West Coast LLCInventors: Maria Graziella Larm, Ronald Harding, Michael Johnston, Albert Zorko Abram, Prema Viyayakumar, Phoebe Sun
-
Publication number: 20140248220Abstract: The present subject matter provides foamable suspension gels that foam after release from a container. The foamable suspension gels contain at least one pharmaceutically active agent that is sparingly soluble to insoluble in water, a second pharmaceutically active agent, and optionally a third active agent.Type: ApplicationFiled: May 12, 2014Publication date: September 4, 2014Applicant: STIEFEL RESEARCH AUSTRALIA PTY LTDInventors: Albert Zorko ABRAM, Lilian FUCHSHUBER
-
Patent number: 8758728Abstract: The present subject matter provides foamable suspension gels that foam after release from a container. The foamable suspension gels contain at least one pharmaceutically active agent that is sparingly soluble to insoluble in water, a second pharmaceutically active agent, and optionally a third active agent.Type: GrantFiled: May 31, 2013Date of Patent: June 24, 2014Assignee: Stiefel Research Australia Pty LtdInventors: Albert Zorko Abram, Lilian Fuchshuber
-
Publication number: 20140042051Abstract: The present invention provides various pharmaceutically active topical delivery compositions. In particular, compositions of the present invention are present in a pressurized container comprising a quick-breaking alcoholic foaming agent, such that when the composition is released, i.e., dispensed, from the pressurized container, a quick-breaking temperature sensitive foam is formed. In addition, the present invention provides various aspects related to such compositions, including methods for modulating a foam characteristic, methods for improving the shelf-life of a pharmaceutically active compound, methods for the percutaneous treatment of various diseases, infections, and illnesses, and methods for evaluating foam characteristics.Type: ApplicationFiled: October 14, 2013Publication date: February 13, 2014Applicant: STIEFEL WEST COAST, LLCInventors: Albert Zorko ABRAM, Lilian FUCHSHUBER
-
Patent number: 8586066Abstract: A topical, foamable composition is provided that includes at least one antifungal agent that is able to penetrate the upper layers of skin and is retained in or on an area to be treated for a prolonged period of time, and that has a residual non-volatile component content less than 25%. In addition, a method of treating fungal diseases including jock itch, tinea, dandruff and sebborheic dermatitis is provided, and includes applying to the affected area of patient requiring such treatment an antifungal composition.Type: GrantFiled: June 21, 2011Date of Patent: November 19, 2013Assignee: Delcor Asset CorporationInventors: Greg Davey, Albert Zorko Abram
-
Patent number: 8586008Abstract: The present invention provides various pharmaceutically active topical delivery compositions. In particular, compositions of the present invention are present in a pressurized container comprising a quick-breaking alcoholic foaming agent, such that when the composition is released, i.e., dispensed, from the pressurized container, a quick-breaking temperature sensitive foam is formed. In addition, the present invention provides various aspects related to such compositions, including methods for modulating a foam characteristic, methods for improving the shelf-life of a pharmaceutically active compound, methods for the percutaneous treatment of various diseases, infections, and illnesses, and methods for evaluating foam characteristics.Type: GrantFiled: November 30, 2011Date of Patent: November 19, 2013Assignee: Stiefel West Coast, LLCInventors: Albert Zorko Abram, Lilian Fuchshuber
-
Publication number: 20130280309Abstract: The present subject matter provides foamable suspension gels that foam after release from a container. The foamable suspension gels contain at least one pharmaceutically active agent that is sparingly soluble to insoluble in water, a second pharmaceutically active agent, and optionally a third active agent.Type: ApplicationFiled: May 31, 2013Publication date: October 24, 2013Inventors: Albert Zorko ABRAM, Lilian FUCHSHUBER
-
Patent number: 8475770Abstract: The present subject matter provides foamable suspension gels that foam after release from a container. The foamable suspension gels contain at least one pharmaceutically active agent that is sparingly soluble to insoluble in water, a second pharmaceutically active agent, and optionally a third active agent.Type: GrantFiled: September 2, 2011Date of Patent: July 2, 2013Assignee: Stiefel Research Australia Pty LtdInventors: Albert Zorko Abram, Lilian Fuchshuber
-
Patent number: 8460641Abstract: An oil-in-water microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, comprising: a first part including at least one occlusive agent and one or more lipophilic surfactants dispersed throughout a second part including water and at least one hydrophilic surfactant, and a non-surfactant amphiphilic type compound, pharmaceutically active ingredient, and water. It has been found that if a non-surfactant amphiphilic type compound is added together with the second part as would conventionally be the case, a microemulsion or sub-micron emulsion is not formed, by adding the so called third part, phase assembly occurs at a lower temperature than would be expected and moreover, this phase appears to assist in maintaining the microemulsion or sub-micron emulsion characteristics of the formulation during storage at normal temperatures.Type: GrantFiled: August 31, 2005Date of Patent: June 11, 2013Assignee: Stiefel Research Australia Pty LtdInventors: Maria Graziella Larm, Ronald Harding, Michael Johnston, Albert Zorko Abram, Prema Vijayakumar, Phoebe Sun
-
Patent number: 8449867Abstract: An oil in water microemulsion or sub-micron emulsion composition for dermal delivery of at least one pharmaceutically active ingredient, is provided. The composition includes an oil phase dispersed throughout a water phase, the oil phase including at least one member selected from the group consisting of an animal oil, a mineral oil, a vegetable oil, a silane member, a siloxane, an ester, a fatty acid, a fat, a halogen compound, and an alkoxylated alcohol; and at least one lipophilic surfactant, the water phase including at least one hydrophilic surfactant, water and optionally a non-surfactant amphiphilic compound, the weight ratio of the at least one hydrophilic surfactant to the at least one lipophilic surfactant being approximately 9.0:1.0 to 2.0:3.0.Type: GrantFiled: June 25, 2009Date of Patent: May 28, 2013Assignee: Stiefel Research Australia Pty LtdInventors: Maria Graziella Larm, Ronald Harding, Michael Johnston, Albert Zorko Abram, Prema Vijayakumar, Phoebe Sun
-
Publication number: 20130108557Abstract: The present invention provides aerosol foams comprising Aloe vera. In particular, the foams comprise (a) Aloe vera, (b) a surfactant and (c) a propellant. The foams may further comprise one or more of the group consisting of an ?-hydroxy acid, a ?-hydroxy acid, a humectant, a thickening agent, a dermatologically acceptable excipient, and mixtures thereof.Type: ApplicationFiled: September 28, 2010Publication date: May 2, 2013Inventors: Albert Zorko Abram, Iulian Goldstein
-
Patent number: 8158109Abstract: The present subject matter provides foamable suspension gels that foam after release from a container. The foamable suspension gels contain at least one pharmaceutically active agent that is sparingly soluble to insoluble in water, a second pharmaceutically active agent, and optionally a third active agent.Type: GrantFiled: March 29, 2007Date of Patent: April 17, 2012Assignee: Stiefel Research Australia Pty LtdInventors: Albert Zorko Abram, Lilian Fuchshuber
-
Publication number: 20120074026Abstract: The present invention provides various pharmaceutically active topical delivery compositions. In particular, compositions of the present invention are present in a pressurized container comprising a quick-breaking alcoholic foaming agent, such that when the composition is released, i.e., dispensed, from the pressurized container, a quick-breaking temperature sensitive foam is formed. In addition, the present invention provides various aspects related to such compositions, including methods for modulating a foam characteristic, methods for improving the shelf-life of a pharmaceutically active compound, methods for the percutaneous treatment of various diseases, infections, and illnesses, and methods for evaluating foam characteristics.Type: ApplicationFiled: November 30, 2011Publication date: March 29, 2012Applicant: STIEFEL RESEARCH AUSTRALIA PTY LTDInventors: Albert Zorko ABRAM, Lilian FUCHSHUBER