Abstract: An injection device comprising a housing (1) and a cartridge holder (2, 20), the housing (1) being provided on the proximal side with a rotatable dose knob (4, 40) and an axially translatable button (5, 50). The housing (1) comprises: a dose setting sleeve (6, 60), a non-rotatable tubular driving element (7, 70) slidingly mounted in the housing (1) and engaged with the dose setting sleeve (6, 60) by a threaded connection, a non-rotatable axially sliding piston rod (15,150), a toothed gear (8, 80) comprising teeth (8.1, 80.1), a driving spring (13, 130). The dose setting sleeve (6, 60) is equipped with at least one ratchet arm (6.4, 60.4) cooperating with the toothed gear (8, 80); the piston rod (15, 150) has at least one row of ratchet teeth (15.1, 150.1) on its external surface; the driving element (7, 70) is on its distal side fixedly connected with at least one driving arm (14, 140) cooperating with the ratchet teeth (15.1, 150.1) of the piston rod (15, 150).

Abstract: A drive mechanism for an applicator for delivering a dose of a medicament, comprising: a dose setting assembly (N), a knob (1), a rotatable and axially non-translatable clutch element (2) coupled in rotation with the knob (1) and cooperating with the dose setting assembly (N), a rotatable piston rod (3) having an external thread (3.2), the piston rod (3) being located inside the clutch element (2), a drive element (4) and a drive spring (5), wherein when a dose is being set (1) by means of the knob (1), the clutch element (2) is rotated so that the drive spring (5) is loaded, while the drive element (4) and the piston rod (3) are immobilized, and when the dose is being delivered, the drive spring (5) is being released causing the drive element (4) to rotate together with the piston rod (3), the piston rod (3) being moved axially in a distal direction, wherein the piston rod (3) is hollow and has an internal thread (3.3) and a shaft (21) having an external thread (21.

Abstract: A device (1) for monitoring the state of an injection applicator comprising an energy source (10) and the following electronic components: an accelerometer (5), a time measuring means (6), a temperature measuring means (7), a processing unit (8) connected to a system adapted to store, process and transfer data, said system including: the time measuring means (6), the accelerometer (5), the temperature measuring means (7) and a memory (9), a user interface (4) connected to the processing unit (8) for presenting information based on the data transferred by the processing unit (8), said monitoring device (1) being connected to a control member (3) of the applicator, and wherein said monitoring device (1) is adapted to operate in a sleep mode and in an active mode, and is further adapted to detect by means of the accelerometer (5) at least a first action and a second action, the first action being related to taking said monitoring device (1) out of the sleep mode and putting it into the active mode, and the secon

Abstract: A drive-control system for an injection device for delivering settable doses of a pharmaceutical substance contained in a cartridge, including a tubular housing body having a longitudinal axis, a proximal end and a distal end connectable to the cartridge enclosure, a helical spring contained in the housing body and a piston rod moveable towards the distal end and blocked in translation towards the proximal end. The housing body includes a control sleeve on which the spring is mounted, which rotatable around the axis, and a setting sleeve translatable along the axis. Rotation of the control sleeve in a first direction combined with compression of the spring causes the setting sleeve to be translated towards the proximal end of the housing body, and extension of the spring causes the setting sleeve to be translated towards the distal end of the housing body and the control sleeve to be rotated in a second direction and the piston rod to be pushed towards the outside of the housing body.

Abstract: A clutch assembly with a blocking system for a medical injection device, in which a first ratchet sleeve (3) is mounted on the clutch sleeve (2), the first ratchet sleeve (3) being rotatable in two directions and cooperating with a second ratchet sleeve (4) which is mounted on the first ratchet sleeve (3), the second ratchet sleeve (4) being rotatable only in one direction, the housing (1) has an internal toothed ring (1.1), the first ratchet sleeve (3) has at least one ratchet (3.1), and the second ratchet sleeve (4) has an internal toothed ring (4.1) and at least one ratchet (4.2). The second ratchet sleeve (4) and the housing (1) have blocking means (4.3, 1.2) for preventing the arming of the device when an insufficient volume of the medicament remains in the container, by blocking the rotation of the second ratchet sleeve (4) in relation to the housing (1).

Abstract: A drug delivery device comprising a system for measuring a set dose or a delivered dose comprising at least one magnetic sensor and a magnetic field source characterizes in that the device comprises an element carrying the magnetic field source (9) configured so that during delivering a dose the element moves axially with respect to an element carrying the at least one magnetic sensor (10) measuring a magnetic field, wherein the system for measuring a set dose or a delivered dose comprises a device (13) configured to determine a set dose or a delivered dose based on the magnetic field measurements.

Abstract: A drive mechanism for an applicator for delivering multiple doses of medicament, comprising an axially moveable piston rod (2) having a non-circular cross-section and an external thread, a mounting member (4) with one member of a pair of blocking means, said pair comprising a toothed rim (4a, 3b) and at least one ratchet arm (3a, 4b); a drive sleeve (3) having an internal thread coupled with the thread of the piston rod (2), the drive sleeve (3) provided on the distal end with the other member of said pair of blocking means. A method of assembling the drive mechanism of the invention, in which the drive sleeve (3) together with the piston rod (2) and the piston rod guide (5) into the mounting member (4) are inserted from the side of the distal end of the applicator.

Abstract: An injection device for delivering equal doses of a fluid contained in a reservoir, the device having a housing, and an arming mechanism and a dose delivery mechanism arranged therein, the housing coupled to an enclosure for the reservoir. The arming mechanism includes an axially non-displaceable and rotatable setting sleeve. The setting sleeve is coupled with a spring strained by the rotation of the setting sleeve during arming of the device. The dose delivery mechanism includes a screw ring and a nonrotatable and axially displaceable piston rod within the setting sleeve. The piston rod cooperates with the screw ring so that during arming, the screw ring and the piston rod are immobilized, and during delivery of each dose the piston rod is displaced along the housing due to unwinding of the spring and rotation of the screw ring, the displacement of the piston rod causing the fluid to be discharged from the reservoir.

Abstract: An injection device for delivering equal doses of a fluid contained in a reservoir, the device having a housing, and an arming mechanism and a dose delivery mechanism arranged therein, the housing coupled to an enclosure for the reservoir. The arming mechanism includes an axially non-displaceable and rotatable setting sleeve. The setting sleeve is coupled with a spring strained by the rotation of the setting sleeve during arming of the device. The dose delivery mechanism includes a screw ring and a non-rotatable and axially displaceable piston rod within the setting sleeve. The piston rod cooperates with the screw ring so that during arming, the screw ring and the piston rod are immobilized, and during delivery of each dose the piston rod is displaced along the housing due to unwinding of the spring and rotation of the screw ring, the displacement of the piston rod causing the fluid to be discharged from the reservoir.

Abstract: A drive-control system for an injection device for delivering settable doses of a pharmaceutical substance contained in a cartridge, including a tubular housing body having a longitudinal axis, a proximal end and a distal end connectable to the cartridge enclosure, a helical spring contained in the housing body and a piston rod moveable towards the distal end and blocked in translation towards the proximal end. The housing body includes a control sleeve on which the spring is mounted, which rotatable around the axis, and a setting sleeve translatable along the axis. Rotation of the control sleeve in a first direction combined with compression of the spring causes the setting sleeve to be translated towards the proximal end of the housing body, and extension of the spring causes the setting sleeve to be translated towards the distal end of the housing body and the control sleeve to be rotated in a second direction and the piston rod to be pushed towards the outside of the housing body.

Abstract: A device (1) for monitoring the state of an injection applicator comprising an energy source (10) and the following electronic components: an accelerometer (5), a time measuring means (6), a temperature measuring means (7), a processing unit (8) connected to a system adapted to store, process and transfer data, said system including: the time measuring means (6), the accelerometer (5), the temperature measuring means (7) and a memory (9), a user interface (4) connected to the processing unit (8) for presenting information based on the data transferred by the processing unit (8), said monitoring device (1) being connected to a control member (3) of the applicator, and wherein said monitoring device (1) is adapted to operate in a sleep mode and in an active mode, and is further adapted to detect by means of the accelerometer (5) at least a first action and a second action, the first action being related to taking said monitoring device (1) out of the sleep mode and putting it into the active mode, and the secon

Abstract: A drive-control system for an injection device for delivering settable doses of a pharmaceutical substance contained in a cartridge (3), the system comprising a tubular housing body (2) having a longitudinal axis (A-A), a proximal end (2a) and a distal end (2b) connectable to the cartridge enclosure (3), the system further comprising a helical spring (7) contained in the housing body and a piston rod (6) moveable towards said distal end (2b) and blocked in translation towards the proximal end (2a).

Abstract: A clutch assembly with a blocking system for a medical injection device, in which a first ratchet sleeve (3) is mounted on the clutch sleeve (2), the first ratchet sleeve (3) being rotatable in two directions and cooperating with a second ratchet sleeve (4) which is mounted on the first ratchet sleeve (3), the second ratchet sleeve (4) being rotatable only in one direction, the housing (1) has an internal toothed ring (1.1), the first ratchet sleeve (3) has at least one ratchet (3.1), and the second ratchet sleeve (4) has an internal toothed ring (4.1) and at least one ratchet (4.2). The second ratchet sleeve (4) and the housing (1) have blocking means (4.3, 1.2) for preventing the arming of the device when an insufficient volume of the medicament remains in the container, by blocking the rotation of the second ratchet sleeve (4) in relation to the housing (1).

Abstract: A setting mechanism for a dosing device, in particular for a device for dosing pharmaceutical or therapeutic substances, the setting mechanism including: a controlling assembly for connecting the setting mechanism with a dose setting element of the dosing device; a driving assembly for connecting the setting mechanism with a driving element of the dosing device; a dosing assembly for connecting the setting mechanism with a dosing element of the dosing device. The controlling assembly is coupled with the dosing assembly by a spring element, which can deform from a coupled position to a decoupled position during rotation of the dose setting element. The spring element is configured to allow a displacement of the controlling assembly with respect to the dosing assembly. In the coupled position the spring element is configured to block a rotation of the controlling assembly with respect to the dosing assembly.

Abstract: Injection device for delivering a defined number (n) of equal doses of a fluid substance contained in a reservoir (P), the device having a housing (1) within which an arming mechanism and a dose delivery mechanism are arranged along the longitudinal axis of the housing, the housing (1) being coupled to an enclosure (3) adapted for receiving the reservoir (P) with the fluid substance, the arming mechanism comprising a setting sleeve (5) which is axially non-displaceable and rotatable around the axis of the housing in two opposite directions by a defined setting angle (a), the setting sleeve (5) being coupled with a spring (10) which is strained by the rotation of the setting sleeve (5) during arming of the device; the dose delivery mechanism comprising a screw ring (6) and a piston rod (4) which is non-rotatable and axially displaceable within the setting sleeve (5), the piston rod (4) cooperating with the screw ring (6) so that during arming of the device the screw ring (6) and the piston rod (4) are immobili

Abstract: A drive-control system for an injection device for delivering set-table doses of a pharmaceutical substance contained in a cartridge (3), the system comprising a tubular housing body (2) having a longitudinal axis (A-A), a proximal end (2a) and a distal end (2b) connectable to the cartridge enclosure (3), the system further comprising a helical spring (7) contained in the housing body and a piston rod (6) moveable towards said distal end (2b) and blocked in translation towards the proximal end (2a).

Abstract: A setting mechanism for a dosing device, in particular for a device for dosing pharmaceutical or therapeutic substances, the setting mechanism including: a controlling assembly for connecting the setting mechanism with a dose setting element of the dosing device; a driving assembly for connecting the setting mechanism with a driving element of the dosing device; a dosing assembly for connecting the setting mechanism with a dosing element of the dosing device. The controlling assembly is coupled with the dosing assembly by a spring element, which can deform from a coupled position to a decoupled position during rotation of the dose setting element. The spring element is configured to allow a displacement of the controlling assembly with respect to the dosing assembly. In the coupled position the spring element is configured to block a rotation of the controlling assembly with respect to the dosing assembly.