Patents by Inventor Alberto Mantovani

Alberto Mantovani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of identifying modulators of ChemerinR polypeptides
    Patent number: 7842453
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: November 30, 2010
    Assignee: Euroscreen S.A.
    Inventors: Valeria Wittamer, Jean-François Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul
  • COMPOSITIONS AND METHODS COMPRISING A LIGAND OF CHEMERINR
    Publication number: 20100267138
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: February 19, 2009
    Publication date: October 21, 2010
    Inventors: Valerie Wittamer, J. F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms, Silvano Sozzani
  • Compositions comprising a ligand of Chemerin R
    Patent number: 7666401
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: February 23, 2010
    Assignee: Euroscreen S.A.
    Inventors: Valeria Wittamer, J. F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul, Cecile Loison, Frederic Ooms
  • Compositions and methods comprising a ligand of chemerin R
    Publication number: 20100009345
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: October 26, 2007
    Publication date: January 14, 2010
    Inventors: Valeria Wittamer, J.F. Mirjolet, Isabelle Migeotte, Daivd Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
  • METHOD FOR MEASURING PLASMA LEVELS OF LONG PENTRAXIN PTX3
    Publication number: 20090317843
    Abstract: The present invention relates to a method for measuring PTX3 in a biological fluid, particularly in human or animal plasma. Particularly, the present invention relates to a method for measuring PTX3 levels in a human or animal derived plasma sample, comprising a stage of the treatment of said plasma sample with a red blood cell agglutinating agent and a subsequent stage of determining the plasma levels of PTX3.
    Type: Application
    Filed: December 22, 2006
    Publication date: December 24, 2009
    Inventors: Alberto Mantovani, Giuseppe Peri, Fabio Pasqualini
  • Functional antibodies that specifically bind to the Chemerin receptor
    Patent number: 7582734
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: September 1, 2009
    Assignee: Euroscreen S.A.
    Inventors: Valeria Wittamer, Jean-François Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Lepoul, Cecile Loison, Frederic Ooms
  • PTX3 as an early prognostic indicator of cardiovascular and cerebrovascular pathologies
    Patent number: 7550269
    Abstract: A method for the early determination of the risk of death or heart failure in infarction patients, and the risk of death, relapse or complications in ictus patients, the method being based on the determination of PTX3 from plasma or blood.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: June 23, 2009
    Inventors: Roberto Latini, Giuseppi Peri, Alberto Mantovani, Aldo P. Maggioni
  • Compositions and Methods Comprising a Ligand of ChemerinR
    Publication number: 20090081729
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: August 1, 2008
    Publication date: March 26, 2009
    Applicant: Euroscreen S.A.
    Inventors: Valeria Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
  • Compositions and methods comprising a ligand of chemerin R
    Publication number: 20090047741
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: October 30, 2007
    Publication date: February 19, 2009
    Inventors: Valeria Wittamer, J.F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms, Silvano Sozzani
  • Method For the in Vitro Diagnosis of Autoimmune Immune Response by Detection of Antibodies Directed Against The Pentraxin 3 Antigen
    Publication number: 20090023166
    Abstract: A method for the in vitro diagnosis of an autoimmune immune response in an individual by detection, in a biological fluid from said individual, of antibodies directed against the pentraxin 3 (PTX3) antigen, characterized in that the presence of antibodies directed against the PTX3 antigen (anti-PTX3 antibodies) are determined in a biological fluid from the individual, and kits for implementing the method.
    Type: Application
    Filed: January 19, 2007
    Publication date: January 22, 2009
    Inventors: Pascale Jeannin, Yves Delneste, Alberto Mantovani
  • Antibody that specifically binds to Chemerin receptor ligand precursor
    Patent number: 7470772
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: December 30, 2008
    Assignee: Euroscreen s.a.
    Inventors: Valeria Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms
  • Diagnostic Test for Inflammatory Endothelial Dysfunctions in Pregnancies
    Publication number: 20080311603
    Abstract: The present invention relates to a diagnostic test for inflammatory endothelial dysfunctions in pregnant women. Particularly, the present invention relates to a method of diagnosing or evaluating the risk of contracting an inflammatory endothelial dysfunction of the maternal compartment comprising the following steps: a) detecting the plasma levels of long pentraxin PTX3 in blood samples taken from a pregnant woman; b) comparing the PTX3 plasma level data, obtained according to step a), with statistically significant PTX3 plasma level data of normal pregnant population.
    Type: Application
    Filed: December 18, 2006
    Publication date: December 18, 2008
    Inventors: Alberto Mantovani, Cecilia Garlanda, Andrea Doni, Irene Cetin
  • Monoclonal Antibodies, Hybridomas, Improved Method for Determining the Protein Ptx3 and Kit for Said Determination
    Publication number: 20080261251
    Abstract: Method for determining the level of PTX3 protein in a sample of a biological fluid; hybridoma capable of producing a rat anti-PTX3 monoclonal antibody where said hybridoma is selected from the group comprising MNB10 and Pen-3; specific anti-PTX3 rat monoclonal antibody selected from the monoclonal antibodies produced by the hybridomas MNB10 and Pen-3; kit for determining the level of PTX3 protein in a biological fluid wherein the said kit includes a rat anti-PTX3 monoclonal antibody.
    Type: Application
    Filed: April 27, 2005
    Publication date: October 23, 2008
    Applicant: FARMA DEVELOPMENT S.R.L.
    Inventors: Alberto Mantovani, Giuseppe Peri
  • Isolated ligand of ChemerinR
    Patent number: 7419658
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: June 25, 2003
    Date of Patent: September 2, 2008
    Assignee: Euroscreen s.a.
    Inventors: Valerie Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
  • Compositions comprising a ligand of chemerinR
    Publication number: 20080125357
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screening assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: March 13, 2006
    Publication date: May 29, 2008
    Inventors: Valerie Wittamer, J.F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
  • Methods of identifying modulators of ligand binding to ChemerinR polypeptides
    Patent number: 7332291
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Grant
    Filed: May 20, 2005
    Date of Patent: February 19, 2008
    Assignee: Euroscreen s.a.
    Inventors: Valérie Wittamer, Jean-Francois Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stéphane Brézillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul
  • Pharmaceutical compositions containing the long pentraxin PTX3
    Publication number: 20080015153
    Abstract: Pharmaceutical compositions are described containing a long pentraxin PTX3, particularly human PTX3, for the therapy of infectious and inflammatory or tumour diseases; expression vectors containing cDNA coding for PTX3; recombinant host cells transfected with such vectors; a method for producing substantial amounts of PTX3 involving the culturing of such cells, and the use of said vectors in the gene therapy of tumours.
    Type: Application
    Filed: July 31, 2007
    Publication date: January 17, 2008
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE
    Inventors: Barbara Bottazzi, Martiho Introna, Alberto Mantovani, Annunciata Vecchi
  • Compositions and methods comprising a ligand of ChemerinR
    Publication number: 20070238862
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: September 29, 2006
    Publication date: October 11, 2007
    Inventors: Valeria Wittamer, J.F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms
  • Compositions and methods comprising a ligand of chemerinR
    Publication number: 20070213508
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: September 29, 2006
    Publication date: September 13, 2007
    Inventors: Valeria Wittamer, J.F. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franssen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms
  • Compositions and methods comprising a ligand of ChemerinR
    Publication number: 20070213510
    Abstract: The present invention relates to a G-protein coupled receptor and a novel ligand therefor. The invention provides screeing assays for the identification of candidate compounds which modulate the activity of the G-protein coupled receptor, as well as assays useful for the diagnosis and treatment of a disease or disorder related to the dysregulation of G-protein coupled receptor signaling.
    Type: Application
    Filed: September 29, 2006
    Publication date: September 13, 2007
    Inventors: Valerie Wittamer, J. Mirjolet, Isabelle Migeotte, David Communi, Alberto Mantovani, Silvano Sozzani, Marisa Vulcano, Jean-Denis Franseen, Stephane Brezillon, Michel Detheux, Gilbert Vassart, Marc Parmentier, Emmanuel Le Poul, Cecile Loison, Frederic Ooms