Abstract: Pyrrolidine main protease inhibitors are described that are effective as antiviral compounds.

Abstract: Methods and systems for designing phage therapy cocktails. A candidate phage selector module may be configured to predict lytic activity of phages using a first trained machine learning algorithm, and select candidate phages based at least in part on predicted lytic activity. A cocktail generator module may be configured to generate a set of phage cocktails using a second trained machine learning algorithm, based at least in part on predicted lytic activity. A feedback panel module may be configured to receive feedback information associated with phage cocktails, and use the feedback information to train the first and/or second trained machine learning algorithms.

Abstract: A bactericidal and virucidal pharmaceutical composition for use on epithelial tissues such as pulmonary, nasal and oral tissues, which comprises a non-steroidal anti-inflammatory drug (NSAID) in a concentration between 5 and 500 mM and a salt, being the NSAID preferably solubilized in a hypertonic saline solution applicable in therapies for viral infections of the Herpes simplex type. The composition can be used in therapies for herpes simplex viral infections, be used as a bactericidal mouthwash, or be vehiculated to the lung by using a nebuliser, for cystic fibrosis.

Abstract: An aspect of the disclosure provides for an optical-phased array (OPA) comprising a star coupler coupled to a plurality of grating couplers, wherein the star coupler comprises multiple inputs and multiple outputs. In some embodiments, each output of the star coupler is coupled to a grating coupler of the plurality of grating couplers. In some embodiments, the star coupler is coupled to the plurality of grating couplers by a plurality of optical delay lines. In some embodiments each output of the star coupler is coupled to a grating coupler of the plurality of grating couplers via an optical delay line of the plurality of optical delay lines. In some embodiments, the OPA further includes an optical switch coupled to the multiple inputs of the star coupler, and at least one tunable laser. Another aspect of the disclosure provides a method for steering light using the OPA.

Abstract: In a method for a cooktop, in particular for producing and/or operating the cooktop, which has at least one variable cooking surface, the cooking surface is partitioned in an operating mode along a partitioning direction into a plurality of heating zones to which at least one heating parameter is assigned in each case in a location-dependent manner in order to heat a cooking utensil that is deposited on the heating zone. In order to ensure flexible production and/or flexible operation of the cooktop, during partitioning of the cooking surface into the heating zones in at least one peripheral region of the cooking surface, at least one cooking utensil characteristic is taken into account.

Abstract: Opaque cleaning compositions substantially free of opacifying agents and pearlizers, and methods for the same are disclosed. The cleaning composition may include a synergistic combination of a surfactant system and one or more salts. The surfactant system may include a nonionic surfactant and two anionic surfactants, and the one or more salts may include a multivalent ion. In some examples, the cleaning composition is free of thickeners.

Abstract: Described herein are solvates of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including crystalline forms, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the solvates, as well as methods of using the solvates, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract: Described herein are solvates of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including crystalline forms, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the solvates, as well as methods of using the solvates, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract: A urine-detection device with adhesive tape and an emitter sensor allows the easy and economic provision of a urine detector, preventing the need for special nappies, sanitary towels or pad. The device has a strip of tape equipped with two parallel, longitudinal metallic conductors to which a 90 k? resistor is connected by means of superposition, adhesion or printing. The resistor is situated at one end of the tape strip, close to a pre-marked fold, near to an area intended to connect a unit formed by a supporting member and the emitter sensor, which produces in-situ visual warnings by means of LEDs when a control button is pressed and which is programmed to continually transmit data to a control centre panel by means of a wireless connection, to facilitate normality information and information regarding the need for attention because of a wet nappy.

Abstract: Described herein are solvates of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including crystalline forms, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the solvates, as well as methods of using the solvates, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract: A method for continuously evaluating the effectiveness of debridement of a root canal of a tooth, the tooth having an open access cavity and an apex end, includes delivering a fluid to the open access cavity of the tooth, evacuating the fluid near the apex end of the tooth such that the fluid flushes most of the root canal before being evacuated, and continuously evaluating the evacuated fluid for at least one of a presence of debris, a concentration level of the debris, or a type of the debris. An apparatus for use in debriding a root canal of a tooth includes a microcannula or a macrocannula configured to evacuate a fluid in the root canal, and a sensing mechanism fluidically coupled to the microcannula or the macrocannula, the sensing mechanism configured to continuously sense debris in the evacuated fluid in real time.

Abstract: Described herein are solvates of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including crystalline forms, and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions that include the solvates, as well as methods of using the solvates, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

Abstract: A method for continuously evaluating the effectiveness of debridement of a root canal of a tooth, the tooth having an open access cavity and an apex end, includes delivering a fluid to the open access cavity of the tooth, evacuating the fluid near the apex end of the tooth such that the fluid flushes most of the root canal before being evacuated, and continuously evaluating the evacuated fluid for at least one of a presence of debris, a concentration level of the debris, or a type of the debris. An apparatus for use in debriding a root canal of a tooth includes a microcannula or a macrocannula configured to evacuate a fluid in the root canal, and a sensing mechanism fluidically coupled to the microcannula or the macrocannula, the sensing mechanism configured to continuously sense debris in the evacuated fluid in real time.

Abstract: The present invention extends to methods, systems, and computer program products for sharing healthcare information in private collaborative networks. A hierarchy of rules includes patient rules for each of one or more patients. For each patient, the patient rules define a private collaborative network for sharing healthcare information related to the patient among a plurality of designated entities. A computer stores healthcare information related to the one or more patients. The computer receives request from entities requesting access to stored healthcare information related to the one or more patients. The computer refers to patient's rules within the hierarchy of rules to determine what, if any, subset of the patient's stored healthcare information is accessible to the requesting entity. The computer provides accessible subsets of stored healthcare information to the requesting entity in accordance with the patient rules.

Abstract: An apparatus and method for hardware protection of a virtual machine monitor (VMM) runtime integrity watcher is described. A set of one or more hardware range registers that protect a contiguous memory space that is to store the VMM runtime integrity watcher. The set of hardware range registers are to protect the VMM runtime integrity watcher from being modified when loaded into the contiguous memory space. The VMM runtime integrity watcher, when executed, performs an integrity check on a VMM during runtime of the VMM. Execution of the VMM runtime integrity watcher is triggered by a timer event generated based on multiple frequency bands.

Abstract: The present invention extends to methods, systems, and computer program products for sharing healthcare information in private collaborative networks. A hierarchy of rules includes patient rules for each of one or more patients. For each patient, the patient rules define a private collaborative network for sharing healthcare information related to the patient among a plurality of designated entities. A computer stores healthcare information related to the one or more patients. The computer receives request from entities requesting access to stored healthcare information related to the one or more patients. The computer refers to patient's rules within the hierarchy of rules to determine what, if any, subset of the patient's stored healthcare information is accessible to the requesting entity. The computer provides accessible subsets of stored healthcare information to the requesting entity in accordance with the patient rules.

Abstract: The present invention extends to methods, systems, and computer program products for collecting and transferring physiological data. Different physiological monitoring appliances can be attached to a portable physiological data collection device. Each physiological monitoring appliance can collect a different physiological data (blood glucose data, heart rate data, etc.) from an individual. Different physiological data can be collected and stored at the portable physiological data collection device. In response to a triggering event, a connection can be established to an external computer system. The stored physiological data can be transferred over the established connection to the external computer system. In some embodiments, the external computer system is a healthcare server that shares collected physiological data as well as other healthcare information with designated entities (e.g., family, doctors, etc.).

Abstract: An apparatus and method for hardware protection of a virtual machine monitor (VMM) runtime integrity watcher is described. A set of one or more hardware range registers that protect a contiguous memory space that is to store the VMM runtime integrity watcher. The set of hardware range registers are to protect the VMM runtime integrity watcher from being modified when loaded into the contiguous memory space. The VMM runtime integrity watcher, when executed, performs an integrity check on a VMM during runtime of the VMM. Execution of the VMM runtime integrity watcher is triggered by a timer event generated based on multiple frequency bands.

Abstract: A technique includes providing a virtual trusted platform module for a virtual machine and containing the virtual trusted platform module within a secure enclave of a physical platform.

Abstract: A technique includes on a physical platform, providing a supervisor to manage a lifecycle of a virtual trusted platform module. The technique includes using the supervisor to sign a certificate for an attestation identity key used by the virtual trusted platform module.