Abstract: The present disclosure provides compositions and methods of using gene therapy to decrease cell migration and metastasis and reduce tumor mass or burden. The methods disclosed herein employ plasmids, vectors, and non-viral vectors that contain PCBP1 and/or PCBP1 mutants which inhibit the expression of cancer biomarkers and decrease cell migration or tumor size.

Abstract: Provided herein are novel antibody sequences that bind to CD147 and inhibit viral or parasite invasion, reduce inflammation, and reduce cancer cell viability. The present disclosure also provides methods of using these antibodies to treat viral infection and cancer.

Abstract: The present disclosure provides compositions and methods of using gene therapy to create induced pluripotent stem cells (iPSCs) without inducing cancer or tumorigenesis. The methods disclosed herein employ plasmids and vectors that contain transcription factors and an anti-oncogene such as PCBP1 which inhibits the expression of cancer biomarkers and concomitant oncogenesis.

Abstract: A fantasy sports visual simulation system providing an audiovisual experience that allows contest participants and spectators to view a videogame-like model of a virtual fantasy sports contest. These simulations can occur at any time between any two or more contest participants, like mini contests within the context of a broader league. Once a league is formed and team rosters are created, numerical calculations are performed based on real-athlete statistics to determine a current “state” of performance for all virtual athletes in gameplay. Further simulation inputs can be provided by artificial intelligence, coaching, randomization, and other factors. This statistical analysis is the basis for assigning performance variables to each virtual athlete, which allows the system to calculate numerical point values based on the performance of each virtual athlete and team in this fantasy sports visual simulation system.

Abstract: The disclosure teaches antibodies that are useful, inter alia, in methods for detecting and treating human cancer. In a particular aspect, the disclosure teaches novel antibodies that are useful for detecting and treating human breast cancer. In some embodiments, the disclosure teaches novel antibodies that bind to filamin A. In some embodiments, the antibodies are intrabodies.

Abstract: The present disclosure provides compositions and methods of using gene therapy to decrease cell migration and metastasis and reduce tumor mass or burden. The methods disclosed herein employ plasmids, vectors, and non-viral vectors that contain PCBP1 and/or PCBP1 mutants which inhibit the expression of cancer biomarkers and decrease cell migration or tumor size.

Abstract: A fantasy sports visual simulation system providing an audiovisual experience that allows contest participants and spectators to view a videogame-like model of a virtual fantasy sports contest. These simulations can occur at any time between any two or more contest participants, like mini contests within the context of a broader league. Once a league is formed and team rosters are created, numerical calculations are performed based on real-athlete statistics to determine a current “state” of performance for all virtual athletes in gameplay. Further simulation inputs can be provided by artificial intelligence, coaching, randomization, and other factors. This statistical analysis is the basis for assigning performance variables to each virtual athlete, which allows the system to calculate numerical point values based on the performance of each virtual athlete and team in this fantasy sports visual simulation system.

Abstract: A fantasy sports visual simulation system providing an audiovisual experience that allows contest participants and spectators to view a videogame-like model of a virtual fantasy sports contest. These simulations can occur at any time between any two or more contest participants, like mini-contests within the context of a broader league. Once a league is formed and team rosters are created, numerical calculations are performed based on real-athlete statistics to determine a current “state” of performance for all virtual athletes in gameplay. This statistical analysis is the basis for assigning performance variables to each virtual athlete, which allows the system to calculate numerical point values based on the performance of each virtual athlete and team in this fantasy sports visual simulation system.

Abstract: A fantasy sports visual simulation system providing an audiovisual experience that allows contest participants and spectators to view a videogame-like model of a virtual fantasy sports contest. These simulations can occur at any time between any two or more contest participants, like mini-contests within the context of a broader league. Once a league is formed and team rosters are created, numerical calculations are performed based on real-athlete statistics to determine a current “state” of performance for all virtual athletes in gameplay. This statistical analysis is the basis for assigning performance variables to each virtual athlete, which allows the system to calculate numerical point values based on the performance of each virtual athlete and team in this fantasy sports visual simulation system.