Patents by Inventor Albertus Henricus Maria Theresia Van Heertum

Albertus Henricus Maria Theresia Van Heertum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 2-alkyl quinazolinone derivatives as PARP inhibitors
    Patent number: 8188103
    Abstract: The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions including compounds of formula (I) wherein R1, R3, L, X, Y and Z have defined meanings.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: May 29, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Marcel Jozef Maria Van der Aa, Albertus Henricus Maria Theresia Van Heertum, Jacobus Alphonsus Josephus van Dun, Maria Victorina Francisca Somers, Walter Boudewijn Leopold Wouters
  • SUBSTITUTED 2-ALKYL QUINAZOLINONE DERIVATIVES AS PARP INHIBITORS
    Publication number: 20110077245
    Abstract: The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein R1, R3, L, X, Y and Z have defined meanings.
    Type: Application
    Filed: December 3, 2010
    Publication date: March 31, 2011
    Inventors: Marcel Jozef Maria Van der Aa, Albertus Henricus Maria Theresia Van Heertum, Jacobus Alphonsus Josephus van Dun, Maria Victorina Francisca Somers, Walter Boudewijn Leopold Wouters
  • Substituted 2-alkyl quinazolinone derivatives as PARP inhibitors
    Patent number: 7875621
    Abstract: The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions containing compounds of formula (I) wherein R1, R3, L, X, Y and Z have defined meanings.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: January 25, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Marcel Jozef Maria Van Der Aa, Albertus Henricus Maria Theresia Van Heertum, Jacobus Alphonsus Josephus Van Dun, Maria Victorina Francisca Somers, Walter Boudewijin Leopold Wouters
  • 4-[3-benzofuranyl]piperidinyl and 4-[3-benzothienyl]piperidinyl derivatives
    Patent number: 6348457
    Abstract: The invention is concerned with novel compounds of the formula the pharmaceutically acceptable acid addition salts thereof and the stereochemically isomeric forms thereof, wherein X is oxygen or sulphur; R1 is hydrogen or halo; R2 is hydrogen, C1-4alkyl, phenylmethyl or halophenylmethyl; Alk is C1-4alkanediyl; —Z—A— is a bivalent radical selected from the group consisting of —S—CH2—CH2, —S—CH2—CH2—CH2—, —S—CH═CH—, —CH═CH—CH═CH—, —C(═CHR3)—CH2—CH2—CH2—, —CH═CH—O—, —CHR4—CH2—CH2—, —CHR4—CH2—CH2—CH2—, —CHR4—CH2—CH2—CH2—CH2—; in said bivalent radicals one hydrogen may be replaced by C1-4alkyl; R3 is phenyl or halophenyl; each R4 independently represents hydrogen, hydroxy, phenylmethyl or halophenylmethyl.
    Type: Grant
    Filed: January 5, 1995
    Date of Patent: February 19, 2002
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Vandenberk, Ludo Edmond Josephine Kennis, Albertus Henricus Maria Theresia Van Heertum