Patents by Inventor Alcide Perboni
Alcide Perboni has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8188290Abstract: The present invention relates to a new and useful process for preparing N,N-substituted carbamoyl halides from secondary amines, carbon dioxide, trialkylsilyl chloride and a halogenating agent.Type: GrantFiled: October 26, 2006Date of Patent: May 29, 2012Assignee: Glaxo Group LimitedInventors: Ilaria Bientinesi, Zadeo Cimarosti, Giuseppe Guercio, Corinne Leroi, Alcide Perboni
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Publication number: 20100184996Abstract: A process for the formation of 2-(methyloxy)-N-[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]-4,6-bis(trifluoromethyl)benzamide is disclosed, comprising treatment of 2,4-ditrifluoromethyl-6-methoxy-benzoic acid with an arylsulphonyl halide, C1-6alkylsulphonyl halide or di-C1-6alkylphosphoryl chloride, in the presence of a base and an aprotic solvent; followed by reaction with [2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]amine or a salt thereof. Also disclosed is a process for the formation of [2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]amine comprising: i) treatment of an ?-haloketone with an alcohol in the presence of a base followed by reaction with pyrrolidine; ii) treatment of the product of stage i) with Ar—CH(R5)N H2 wherein R5 is C1-4alkyl and Ar is optionally substituted phenyl, followed by reduction with a sodium borohydride derivative; and iii) reduction of the product of stage ii) with hydrogen and a palladium catalyst.Type: ApplicationFiled: June 18, 2008Publication date: July 22, 2010Applicant: GLAXO GROUP LIMITEDInventors: Alcide Perboni, Nicola Giubellina
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Patent number: 7589206Abstract: The present invention relates to novel pyrrolopyridine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.Type: GrantFiled: June 7, 2005Date of Patent: September 15, 2009Assignee: Glaxo Group LimitedInventors: Andrew John Eatherton, Gerard Martin Paul Giblin, Matthew Russell Johnson, William Leonard Mitchell, Brian Peter Slingsby, Alcide Perboni
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Publication number: 20090023757Abstract: The present invention relates to a novel process for preparing compounds of formula (IA), which are potent and specific antagonists of corticotropin-releasing factor (CRF) receptors, from intermediate compounds of formula (I), by a coupling reaction catalysed by copper.Type: ApplicationFiled: April 6, 2006Publication date: January 22, 2009Inventors: Daniele Andreotti, Sergio Bacchi, Monica Delpogetto, Simone Guelfi, Alcide Perboni, Arianna Ribecai, Simone Spada, Paolo Stabile, Marsia Tampieri
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Publication number: 20080312444Abstract: The present invention relates to a novel process for preparing compounds of formula (IA), which are potent and specific antagonists of corticotropin-releasing factor (CRF) receptors, from intermediate compounds of formula (I), by a coupling reaction catalysed by copper.Type: ApplicationFiled: April 6, 2006Publication date: December 18, 2008Inventors: Sergio Bacchi, Monica Delpogetto, Simone Guelfi, Alcide Perboni, Arianna Ribecai, Paolo Stabile, Marsia Tampieri
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Publication number: 20080262234Abstract: The present invention relates to a new and useful process for preparing N,N-substituted carbamoyl halides from secondary amines, carbon dioxide, trialkylsilyl chloride and a halogenating agent.Type: ApplicationFiled: October 26, 2006Publication date: October 23, 2008Inventors: Ilaria Bientinesi, Zadeo Cimarosti, Giuseppe Guercio, Corinne Leroi, Alcide Perboni
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Publication number: 20070219229Abstract: The present invention relates to novel pyrrolopyridine derivatives, pharmaceutical compositions containing these compounds and their use in the treatment of diseases, particularly pain, which diseases are caused directly or indirectly by an increase or decrease in activity of the cannabinoid receptor.Type: ApplicationFiled: June 7, 2005Publication date: September 20, 2007Applicant: GLAXO GROUP LIMITEDInventors: Andrew Eatherton, Gerard Giblin, Matthew Johnson, William Mitchell, Brian Slingsby, Alcide Perboni
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Patent number: 6239287Abstract: A process for the preparation of the phosphonium compound of formula (1), which comprises reacting N-phenylpyrrolidinone (II), with pyridinium bromide perbromide, in the presence of a tertiary organic base and a suitable lewis acid and then treating the resultant bromo derivative (III) with the phosphine (IV, R1R2R1P) and the use of compound (I) when so prepared for the preparation of the glycine antagonist.Type: GrantFiled: September 7, 1999Date of Patent: May 29, 2001Assignee: Glaxo Wellcome SpAInventors: Simon Charles Dolan, Paolo Maragni, Alcide Perboni
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Patent number: 5693634Abstract: The present invention relates to compounds of formula (I) ##STR1## and salts and metabolically labile esters thereof. These compounds and compositions containing them have antibacterial activity. Processes for preparing these compounds are also disclosed, as well as methods of treatment of a human or non-human subject to combat bacterial infections.Type: GrantFiled: May 9, 1996Date of Patent: December 2, 1997Assignee: Glaxo Wellcome S.p.A.Inventors: Alcide Perboni, Giorgio Pentassuglia, Daniele Andreotti, John Alexander Winders
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Patent number: 5587374Abstract: A compound of the formula 1-cyclohexyloxycarbonyloxethyl (4S, 8S, 9R 10S, 12R)-4-methoxy-10-(1-hydroxyethyl)-11-oxo-1-azatricyclo[7.2.0.0..sup.3,8 ]undec-2-ene-2-carboxylate which is useful as a pharmaceutical composition to treat bacterial infection.Type: GrantFiled: February 14, 1995Date of Patent: December 24, 1996Assignee: Glaxo SpAInventors: Alcide Perboni, Tino Rossi, Giovanni Gaviraghi, Giorgio Tarzia, Antonella Ursini
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Patent number: 5576312Abstract: The present invention relates to compounds of formula (I) ##STR1## and salts and metabolically labile esters thereof; wherein R is a 5 or 6 membered nitrogen containing heteroaryl group, which heteroaryl group optionally contains 1 or 2 additional heteroatoms selected from nitrogen, oxygen or sulphur and said heteroaryl group is linked to the alkylene chain (CH.sub.2)n via a nitrogen atom in the heteroaryl group; n is an integer from 2 to 4, to processes for their preparation and to their use as antibacterial agents.Type: GrantFiled: February 21, 1995Date of Patent: November 19, 1996Assignee: Glaxo SpAInventors: Roberto Carlesso, Stuart Holman, Alcide Perboni, Tino Rossi
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Patent number: 5426104Abstract: Compounds of general formula (I) ##STR1## in which R.sub.1 represents a hydrogen atom or a hydroxyl protecting group, R.sub.2 represents a hydrogen atom or a carboxyl protecting group, and R.sub.3 represents the group N(R.sub.4)--CH.dbd.NR.sub.5 wherein R.sub.4 represents a hydrogen atom and R.sub.5 represents a hydrogen atom; and salts, metabolically labile esters and solvates thereof and a process for their production. The compounds of formula (I) are either antibacterial agents and or useful intermediates for the preparation of antibacterial agents.Type: GrantFiled: September 21, 1993Date of Patent: June 20, 1995Assignee: Glaxo SpAInventors: Alcide Perboni, Daniele Donati, Giorgio Tarzia
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Patent number: 5407931Abstract: The invention relates to heterocyclic derivatives having antibacterial activity, to processes for their preparation, to compositions containing them, and to their medicinal uses.Type: GrantFiled: September 7, 1990Date of Patent: April 18, 1995Assignee: Glaxo S.p.A.Inventors: Bruno Tamburini, Alcide Perboni, Tino Rossi, Daniele Donati, Daniele Andreotti, Giovanni Gaviraghi, Roberto Carlesso, Claudio Bismara
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Patent number: 5225552Abstract: Compounds of formula ##STR1## in which R.sub.1 represents a hydrogen atom or a hydroxyl protecting group; R.sub.2 represents a hydrogen atom or a trialkylsilyl group, and --X--Y-- represents the epoxide group (A) or the alkene group (B). ##STR2## wherein R.sub.3 represents a C.sub.1-6 alkyl group optionally substituted by halogen or an optionally substituted phenyl group, useful as intermediates in the preparation of antibacterially active compound.Type: GrantFiled: March 6, 1992Date of Patent: July 6, 1993Assignee: Glaxo SpAInventor: Alcide Perboni
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Patent number: 5196528Abstract: Compounds of formula ##STR1## in which R.sub.1 is hydrogen or a hydroxyl protecting group and --X--Y-- is --CH.dbd.CH-- or ##STR2## useful as intermediates in the preparation of antibacterially active compounds.Type: GrantFiled: July 12, 1991Date of Patent: March 23, 1993Assignee: Glaxo S.p.A.Inventors: Alcide Perboni, Claudio Bismara, Giorgio Pentassuglia
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Patent number: 5138048Abstract: Compounds of the general formula (I) ##STR1## in which: R.sub.1 represents a hydroxyl protecting group; andR.sub.2 represents a hydrogen or halogen atom, an azido group, a C.sub.1-3 alkyl group, a group (CH.sub.2).sub.m OR.sub.3 wherein m is zero or one and R.sub.3 represents a hydrogen atom or a hydroxyl protecting group, an azidoethoxy group, a protected hydroxyethoxy group or a group XR.sub.4 in which X is an oxygen atom or the group S(O).sub.n in which n is zero, 1 or 2 and R.sub.4 represents a C.sub.1-5 alkyl, C.sub.3-7 cycloalkyl or phenyl group or when X is oxygen or sulphur then R.sub.4 may also represent the group AlkNR.sub.5 R.sub.6 in which Alk represents a C.sub.2-6 straight or branched alkylene chain and R.sub.5 and R.sub.6 independently represent a hydrogen atom or C.sub.1-4 alkyl group or R.sub.5 and R.sub.6 together with the nitrogen atom to which they are attached form a pyrrolidino or piperidino ring or the group NR.sub.5 R.sub.6 represents a protected amino group, or R.sub.Type: GrantFiled: September 7, 1990Date of Patent: August 11, 1992Assignee: Glaxo S.p.A.Inventors: Bruno Tamburini, Alcide Perboni, Tino Rossi, Daniele Donati, Daniele Andreotti, Giovanni Gaviraghi, Stefano Biondi, Claudio Bismara