Patents by Inventor Aldrich N. K. Lau

Aldrich N. K. Lau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20090023189
    Abstract: Methods and systems for forming water-in-oil emulsions are described. For example, an apparatus is described which includes: a first compartment containing a plurality of particles dispersed in an aqueous phase; a second compartment containing an oil phase; a porous layer separating the first and second compartments; and a device for applying pressure to the first compartment. A method is described which includes: moving an oil phase relative to a surface of a porous layer while simultaneously forcing an aqueous composition comprising particles through the porous layer and into the flowing dispersion medium thereby forming droplets of the aqueous composition containing particles dispersed in the oil phase. The aqueous composition can include one or more nucleic acid templates and reagents for amplifying the nucleic acids such as PCR reagents.
    Type: Application
    Filed: May 12, 2008
    Publication date: January 22, 2009
    Applicant: APPLERA CORPORATION
    Inventors: Aldrich N.K. Lau, Jonathan M. Cassel, John A. Bridgham
  • Patent number: 7480042
    Abstract: Systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.
    Type: Grant
    Filed: June 30, 2005
    Date of Patent: January 20, 2009
    Assignee: Applied Biosystems Inc.
    Inventors: J. Michael Phillips, Aldrich N. K. Lau, Mark F. Oldham, Kevin S. Bodner, Steven J. Boege, Donald R. Sandell, David H. Tracy
  • Publication number: 20080293127
    Abstract: A method for substantially eliminating a cross-linking element of a pressure sensitive adhesive by heating the pressure sensitive adhesive at a temperature of at least 180° C. for a period of time required to thermally decompose the cross-linking element of the pressure sensitive adhesive.
    Type: Application
    Filed: May 22, 2007
    Publication date: November 27, 2008
    Applicant: Applera Corporation
    Inventors: Yuh-Min Chiang, Aldrich N.K. Lau
  • Patent number: 7378260
    Abstract: The present invention provides products and methods of reducing dye artifacts from chain extension reactions.
    Type: Grant
    Filed: April 1, 2005
    Date of Patent: May 27, 2008
    Assignee: Applera Corporation
    Inventors: Michael P. Harrold, Kevin M. Hennessy, Aldrich N. K. Lau, Sean Matthew Desmond
  • Patent number: 7323696
    Abstract: Beads coded with phosphor particles and methods of making and using them are provided.
    Type: Grant
    Filed: January 6, 2005
    Date of Patent: January 29, 2008
    Assignee: Applera Corporation
    Inventors: Charles S. Vann, Charles R. Connell, Aldrich N. K. Lau, Meng C. Taing, Steven M. Menchen
  • Patent number: 6833238
    Abstract: Devices are provided which include supports upon which one or more ion-exchange materials can be disposed for purifying a sample. In various embodiments, the supports include a plurality of deformable members, for example, petal-shaped purification members, that provide binding sites for ion-exchange material and optionally biochemical species, chemicals, salts, or other materials. An apparatus and method are also provided for the insertion and removal of the purification members into respective wells of a multi-well microplate.
    Type: Grant
    Filed: April 14, 2003
    Date of Patent: December 21, 2004
    Assignee: Applera Corporation
    Inventors: Paul O. Ramstad, Michael P. Harrold, Kevin M. Hennessy, Aldrich N. K. Lau
  • Publication number: 20040168918
    Abstract: The invention provides compositions, methods and kits for high speed, high resolution of analytes by capillary electrophoresis starting with uncoated capillaries. The compositions comprise a sieving component, comprising a non-crosslinked acrylamide polymer, and a surface interaction component, comprising at least one uncharged and non-crosslinked water-soluble silica-adsorbing polymer. Methods for employing the novel compositions in capillary electrophoresis are provided. Kits comprising the novel compositions for use in the novel methods are also provided.
    Type: Application
    Filed: March 5, 2004
    Publication date: September 2, 2004
    Applicant: Applera Corporation
    Inventors: Karl O. Voss, Aldrich N.K. Lau
  • Patent number: 6706162
    Abstract: The invention provides compositions, methods and kits for high speed, high resolution of analytes by capillary electrophoresis starting with uncoated capillaries. The compositions comprise a sieving component, comprising a non-crosslinked acrylamide polymer, and a surface interaction component, comprising at least one uncharged and non-crosslinked water-soluble silica-adsorbing polymer. Methods for employing the novel compositions in capillary electrophoresis are provided. Kits comprising the novel compositions for use in the novel methods are also provided.
    Type: Grant
    Filed: September 25, 2000
    Date of Patent: March 16, 2004
    Assignee: Applera Corporation
    Inventors: Karl O. Voss, Aldrich N. K. Lau
  • Publication number: 20040016702
    Abstract: A device for purifying a sample is provided, and includes ion-exchange particles in contact with a substrate. The device can include size-exclusion material and an ion-exchange material.
    Type: Application
    Filed: August 11, 2003
    Publication date: January 29, 2004
    Applicant: Applera Corporation
    Inventors: Kevin M. Hennessy, Aldrich N.K. Lau, Michael P. Harrold
  • Publication number: 20040018559
    Abstract: A size-exclusion ion-exchange particle and a device using the particle are provided wherein the particle includes an ion-exchange core micro-encapsulated by a shell, and the shell includes a polymerization product of a reactive monomer. The shell can be an at least partially cross-linked polymer. The shell can be capable of excluding molecules of a size equal to or larger than a 10 nt ssDNA molecule or molecules of a size equal to or larger than a 100 nt ssDNA molecule, for example, and the core can be capable of ion-exchange. Methods of making size-exclusion ion-exchange particles are also provided, as are methods of purification using the particles.
    Type: Application
    Filed: April 14, 2003
    Publication date: January 29, 2004
    Applicant: Applera Corporation
    Inventors: Aldrich N.K. Lau, Michael P. Harrold
  • Publication number: 20030228706
    Abstract: Devices are provided which include supports upon which one or more ion-exchange materials can be disposed for purifying a sample. In various embodiments, the supports include a plurality of deformable members, for example, petal-shaped purification members, that provide binding sites for ion-exchange material and optionally biochemical species, chemicals, salts, or other materials. An apparatus and method are also provided for the insertion and removal of the purification members into respective wells of a multi-well microplate.
    Type: Application
    Filed: April 14, 2003
    Publication date: December 11, 2003
    Applicant: Applera Corporation
    Inventors: Paul O. Ramstad, Michael P. Harrold, Kevin M. Hennessy, Aldrich N.K. Lau
  • Patent number: 5830385
    Abstract: A liquid crystal light composite in which discrete volumes of a liquid crystal material are dispersed in a matrix material is produced by a process in which a reactive additive formulation is added and photopolymerized. The reactive additive formulation includes mono- and multifunctional compounds in specified proportions and a photoinitiator. The reactive additive formulation reduces the operating field and may also improve other electro-optical properties.
    Type: Grant
    Filed: January 24, 1997
    Date of Patent: November 3, 1998
    Assignee: Raychem Corporation
    Inventors: Aldrich N. K. Lau, Lanchi P. Vo, Robert H. Reamey, John R. Havens, Kathleen Di Zio
  • Patent number: 5738804
    Abstract: A method is disclosed for making a liquid crystal composite including a dye. The method comprises forming volumes in which a liquid crystal material is surrounded by a containment medium, forming a dye dispersion, combining the dye dispersion and the volumes of liquid material, and treating that combination to facilitate the transfer of the dye into the volumes of liquid crystal material.
    Type: Grant
    Filed: January 4, 1996
    Date of Patent: April 14, 1998
    Assignee: Raychem Corporation
    Inventors: Binh Vu Cao, Wayne Montoya, Damoder Reddy, Aldrich N. K. Lau
  • Patent number: 5695594
    Abstract: A method is disclosed for making a liquid crystal light valve in which the electro-optically active element is a liquid crystal composite sandwiched between two electrodes. The liquid crystal composite comprises plural volumes of liquid crystal material dispersed in a polymer matrix. By use of a tie layer, the problem of stress clearing is markedly reduced or eliminated. The tie layer material can be either a liquid crystal material or a telomer, crosslinkable or otherwise.
    Type: Grant
    Filed: January 5, 1996
    Date of Patent: December 9, 1997
    Assignee: Raychem Corporation
    Inventors: Aldrich N. K. Lau, Damoder Reddy, Akira Tomita, Lanchi P. Vo, Brackin L. Andrews, Kathleen Di Zio, Hundi Kamath
  • Patent number: 5571448
    Abstract: A liquid crystal display is made from an encapsulated liquid crystal structure comprising a liquid crystal composition dispersed in a containment medium. Selected additives may be added to the encapsulated liquid crystal structure to improve performance characteristics such as the operating field, the hysteresis, and the voltage holding ratio.
    Type: Grant
    Filed: April 4, 1995
    Date of Patent: November 5, 1996
    Assignee: Raychem Corporation
    Inventors: Mark F. Wartenberg, Harriette Atkins, Robert H. Reamey, Laurence Welsh, James Strain, Janusz Wojtowicz, Wayne Montoya, Paul S. Drzaic, John Havens, Akira Tomita, Aldrich N. K. Lau
  • Patent number: 5484552
    Abstract: A liquid crystal display is made from an encapsulated liquid crystal structure comprising a liquid crystal composition dispersed in a containment medium. Selected additives may be added to the encapsulated liquid crystal structure to improve performance characteristics such as the operating field, the hysteresis, and the voltage holding ratio.
    Type: Grant
    Filed: April 4, 1995
    Date of Patent: January 16, 1996
    Assignee: Raychem Corporation
    Inventors: Mark F. Wartenberg, Harriette Atkins, Robert H. Reamey, Laurence Welsh, James Strain, Janusz Wojtowicz, Wayne Montoya, Paul S. Drzaic, John Havens, Akira Tomita, Aldrich N. K. Lau
  • Patent number: 5427713
    Abstract: A liquid crystal display is made from an encapsulated liquid crystal structure comprising a liquid crystal composition dispersed in a containment medium. Selected additives may be added to the encapsulated liquid crystal structure to improve performance characteristics such as the operating field, the hysteresis, and the voltage holding ratio.
    Type: Grant
    Filed: March 9, 1993
    Date of Patent: June 27, 1995
    Assignee: Raychem Corporation
    Inventors: Mark F. Wartenberg, Harriette Atkins, Robert H. Reamey, Laurence Welsh, James Strain, Janusz Wojtowicz, Wayne Montoya, Paul S. Drzaic, John Havens, Akira Tomita, Aldrich N. K. Lau
  • Patent number: 5395550
    Abstract: Telomers of the structure ##STR1## are disclosed, where R is --CH.sub.3 or H; R' is a C.sub.5 to C.sub.18 alkyl or fluoroalkyl group; n is an integer between 2 and 6 inclusive; and x is an integer between 3 and 26 inclusive. These telomers are surface active and are useful as aids for coating applications.
    Type: Grant
    Filed: March 31, 1994
    Date of Patent: March 7, 1995
    Assignee: Raychem Corporation
    Inventor: Aldrich N. K. Lau
  • Patent number: 5270453
    Abstract: Aromatic bistriazene compounds of the formula ##STR1## wherein --R.sub.1, --R.sub.2, --R.sub.3, and --R.sub.4 are independently --H, --C.sub.6 H.sub.5, --C.sub.6 H.sub.4 Y, or C.sub.1 -C.sub.4 alkyl; --R.sub.5 -- is ##STR2## --R.sub.6 is --F, --Cl, --Br, --CH.sub.3, or --CF.sub.3 ; r is 0, 1, 2, 3, or 4; and --Y is halogen, --NO.sub.2, --C.sub.6 H.sub.5, or C.sub.1 -C.sub.4 alkyl. These bistriazene compounds are useful for cross-linking polymers such as poly(imides), poly(aryl ether ketones), poly(aryl ether sulfones), poly(quinolines), poly(quinoxalines), and nonaromatic fluoropolymers having aliphatic C--H groups.
    Type: Grant
    Filed: November 17, 1992
    Date of Patent: December 14, 1993
    Assignee: Raychem Corporation
    Inventors: Aldrich N. K. Lau, Lanchi P. Vo, Frank W. Mercer
  • Patent number: 5250667
    Abstract: Compounds of the structure ##STR1## where --R' is --F, --CF.sub.3, --CN, or --Cl; each --R", which may be the same or different, is independently selected from the group consisting of C.sub.1 -C.sub.6 alkyl or hydroxyalkyl moieties and aryl moieties; and n is 0 or 1. Such compounds are useful as derivatizing and crosslinking agents for polymers, especially fluorinated poly(arylene ethers).
    Type: Grant
    Filed: September 9, 1992
    Date of Patent: October 5, 1993
    Assignee: Raychem Corporation
    Inventors: Aldrich N. K. Lau, Lanchi P. Vo