Patents by Inventor Aleksey Kazantsev

Aleksey Kazantsev has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for modulating poly(ADP-ribose) polymerase activity
    Publication number: 20070105835
    Abstract: The present invention is based, in part, on assays we conducted that revealed compounds that modulate (e.g., inhibit) PARP-1 and are therefore useful in treating or preventing diseases characterized by abnormal PARP-1 activity (e.g., undesirable PARP-1 activity).
    Type: Application
    Filed: November 7, 2006
    Publication date: May 10, 2007
    Inventor: Aleksey Kazantsev
  • Compositions and methods for modulating interaction between polypeptides
    Publication number: 20050239833
    Abstract: The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another.
    Type: Application
    Filed: March 7, 2005
    Publication date: October 27, 2005
    Inventors: Aleksey Kazantsev, Anne Young, David Housman, Steven Hersch
  • Methods of identifying agents that mediate polypeptide aggregation
    Publication number: 20050221272
    Abstract: The present invention is based, in part, on the discovery of methods for identifying compounds that mediate (by promoting or inhibiting) protein-protein interaction (e.g., aggregation, dimerization, or other physiologially significant association). Compounds that mediate such interaction, which are also within the scope of the invention, can be used to treat Alzheimer's disease, disorders associated with expanded CAG repeats (such as Huntington's disease), and disorders in which polyglutamine-containing transcription factors or coactivators are undesirably active (e.g., disorders associated with homodimerization ofjun or hexamerization of p53.
    Type: Application
    Filed: February 11, 2002
    Publication date: October 6, 2005
    Inventors: David Housman, Aleksey Kazantsev