Patents by Inventor Alena Lizonova

Alena Lizonova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Complementary adenoviral vector systems and cell lines
    Patent number: 7195896
    Abstract: The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic method, particularly relating to gene therapy, vaccination, and the like, involving the use of such recombinants.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: March 27, 2007
    Assignee: GenVec, Inc.
    Inventors: Imre Kovesdi, Douglas E Brough, Duncan L McVey, Joseph T Bruder, Alena Lizonova
  • Method and composition for targeting an adenoviral vector
    Publication number: 20030099619
    Abstract: The invention provides adenoviral coat proteins comprising various non-native ligands. Further, the present invention provides an adenoviral vector that elicits less reticulo-endothelial system (RES) clearance in a host animal than a corresponding wild-type adenovirus. Also provided by the invention is a system comprising a cell having a non-native cell-surface receptor and a virus having a non-native ligand, wherein the non-native ligand of the virus binds the non-native cell-surface receptor of the cell. Using this system, a virus can be propagated. Further provided by the invention is a method of controlled gene expression utilizing selectively replication competence, a method of assaying for gene function, a method of isolating a nucleic acid, and a method of identifying functionally related coding sequences. Additionally, the invention provides a cell-surface receptor, which facilitates internalization.
    Type: Application
    Filed: November 25, 2002
    Publication date: May 29, 2003
    Applicant: GenVec, Inc.
    Inventors: Thomas J. Wickham, Imre Kovesdi, Petrus W. Roelvink, David Einfeld, Douglas E. Brough, Alena Lizonova
  • RCA-free adenoviral vector system and propagation method
    Patent number: 6482616
    Abstract: The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic method, particularly relating to gene therapy, vaccination, and the like, involving the use of such recombinants.
    Type: Grant
    Filed: May 27, 1999
    Date of Patent: November 19, 2002
    Assignee: GenVec, Inc.
    Inventors: Imre Kovesdi, Douglas E. Brough, Duncan L. McVey, Joseph T. Bruder, Alena Lizonova
  • Vectors, cells and methods for the production of deleterious viral eukaryotic gene transfer vectors
    Publication number: 20020155602
    Abstract: The present invention provides a method of in vitro propagation of a viral eukaryotic gene transfer vector comprising a deleterious, i.e., a cytostatic, cytotoxic, or apoptotic, gene in a eukaryotic, e.g., a mammalian, host-production cell, comprising a blocking gene. The blocking gene inhibits the adverse effects of the deleterious gene on the eukaryotic host-production cell. Vectors and cells useful in the context of the present inventive method are also provided.
    Type: Application
    Filed: April 16, 2002
    Publication date: October 24, 2002
    Applicant: GenVec, Inc.
    Inventors: Joseph T. Bruder, Imre Kovesdi, Alena Lizonova
  • Adenovector pharmaceutical composition
    Publication number: 20020110545
    Abstract: The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic method, particularly relating to gene therapy, vaccination, and the like, involving the use of such recombinants.
    Type: Application
    Filed: August 21, 2001
    Publication date: August 15, 2002
    Applicant: GenVec, Inc.
    Inventors: Imre Kovesdi, Douglas E. Brough, Duncan L. McVey, Joseph T. Bruder, Alena Lizonova
  • Vectors, cells, and methods for the production of deleterious adenoviral, herpes viral and adeno-associated viral vectors
    Patent number: 6391612
    Abstract: The present invention provides a method of in vitro propagation of a viral eukaryotic gene transfer vector comprising a deleterious, i.e., a cytostatic, cytotoxic, or apoptotic, gene in a eukaryotic, e.g., a mammalian, host-production cell, comprising a blocking gene. The blocking gene inhibits the adverse effects of the deleterious gene on the eukaryotic host-production cell. Vectors and cells useful in the context of the present inventive method are also provided.
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: May 21, 2002
    Assignee: GenVec, Inc.
    Inventors: Joseph T. Bruder, Imre Kovesdi, Alena Lizonova
  • Complementary adenoviral vector systems and cell lines
    Publication number: 20020031831
    Abstract: The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic method, particularly relating to gene therapy, vaccination, and the like, involving the use of such recombinants.
    Type: Application
    Filed: September 26, 2001
    Publication date: March 14, 2002
    Applicant: GenVec, Inc.
    Inventors: Imre Kovesdi, Douglas E. Brough, Duncan L. McVey, Joseph T. Bruder, Alena Lizonova
  • Complementary adenoviral vector systems and cell lines
    Publication number: 20020004040
    Abstract: The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic method, particularly relating to gene therapy, vaccination, and the like, involving the use of such recombinants.
    Type: Application
    Filed: March 1, 2001
    Publication date: January 10, 2002
    Applicant: GenVec, Inc.
    Inventors: Imre Kovesdi, Douglas E. Brough, Duncan L. McVey, Joseph T. Bruder, Alena Lizonova
  • Complementary adenoviral vector systems and cell lines
    Publication number: 20010043922
    Abstract: The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic method, particularly relating to gene therapy, vaccination, and the like, involving the use of such recombinants.
    Type: Application
    Filed: January 19, 2001
    Publication date: November 22, 2001
    Inventors: Imre Kovesdi, Douglas E. Brough, Duncan L. McVey, Joseph T. Bruder, Alena Lizonova
  • Stocks of recombinant, replication-deficient adenovirus free of replication-competent adenovirus
    Patent number: 5994106
    Abstract: The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic method, particularly relating to gene therapy, vaccination, and the like, involving the use of such recombinants.
    Type: Grant
    Filed: November 26, 1996
    Date of Patent: November 30, 1999
    Assignee: GenVec, Inc.
    Inventors: Imre Kovesdi, Douglas E. Brough, Duncan L. McVey, Joseph T. Bruder, Alena Lizonova
  • Complementary adenoviral systems and cell lines
    Patent number: 5851806
    Abstract: The present invention provides multiply replication deficient adenoviral vectors having a spacer in at least one replication deficient adenoviral region, as well as complementing cell lines therefor. Also provided are means of constructing the multiply replication deficient adenoviral vectors and methods of use thereof, e.g., in gene therapy.
    Type: Grant
    Filed: December 14, 1995
    Date of Patent: December 22, 1998
    Assignee: GenVec, Inc.
    Inventors: Imre Kovesdi, Douglas E. Brough, Duncan L. McVey, Joseph T. Bruder, Alena Lizonova