Abstract: The disclosure provides methods and systems for detecting alternative splicing variants in a patient sample. The methods involve comparison of splice junction data from RNA sequencing with principal splicing isoforms and identifying those sequences, identifying those sequences that do not match the principal splicing isoform. These sequences are categorized into alternative splicing events and documented. Optionally, previously identified target sequences can be utilized in the comparison where the method seeks sequences which do match. Other methods and systems of the present disclosure include those for building a splice profile of alternative splicing variants for a patient sample and those for developing a companion diagnostic test for a treatment method of a disease based on the presence or absence of alternative splicing variants in a patient sample.

Abstract: Classification of individuals based on their glycemic pattern and applications thereof are described. Generally, systems utilize continuous glucose monitoring data to determine glycemic pattern variability, which can be used as a basis to classify and treat individuals.

Abstract: Classification of individuals based on their glycemic pattern and applications thereof are described. Generally, systems utilize continuous glucose monitoring data to determine glycemic pattern variability, which can be used as a basis to classify and treat individuals.