Abstract: The present invention relates to oligomeric compounds comprising at least two peptide moieties that bind specifically to proteoglycans, their payload conjugates and pharmaceutical compositions containing the same. Instant compounds, payload conjugates and pharmaceutical compositions are particularly useful in the treatment of cancer and in diagnostics.

Abstract: An apparatus for the local and/or remote rehabilitation and functional evaluation of the right and/or left hand of a user includes: a number of gym tools for the execution of hand exercises, each gym tool including a mechanical part, a sensor for the transformation of measured physical parameters into electrical signals; a user interface, configured to guide the user in the use of the gym tools, and providing feedbacks to the sequence of user actions; a first processing unit, configured to manage the apparatus functions, signal processing, storing and forwarding information on the measured physical parameters to at least one external device; a short-range communication module, configured to allow a real-time close-distance control of the apparatus; a wide-range communication module, configured to allow the connection to at least one long-distance tele-monitoring system.