Patents by Inventor Alessandro Pini

Alessandro Pini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for removing bacterial toxins from a biological fluid
    Patent number: 11104705
    Abstract: Methods for removing bacterial toxins such as lipopolysaccharide and lipoteichoic acid from a biological fluid with a peptide selected from KKIRVRLSA (SEQ ID NO:1), RRIRVRLSA (SEQ ID NO:2), KRIRVRLSA (SEQ ID NO:3) and RKIRVRLSA (SEQ ID NO:4), the peptide being covalently attached to a solid support through the C-terminus, optionally with the interposition of a linker.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: August 31, 2021
    Assignee: SETLANCE S.R.L.
    Inventors: Alessandro Pini, Chiara Falciani, Luisa Bracci, Jlenia Brunetti, Leila Quercini
  • METHODS FOR REMOVING BACTERIAL TOXINS FROM A BIOLOGICAL FLUID
    Publication number: 20200048307
    Abstract: This invention relates to methods for removing bacterial toxins such as lipopolysaccharide and lipoteichoic acid from a biological fluid. In such method a peptide, selected from the list of KKIRVRLSA, RRIRVRLSA, KRIRVRLSA and RKIRVRLSA, is covalently attached to a solid support through its C-terminus, optionally with the interposition of a linker, and is used to capture the toxins. This invention also relates to such derivatised solid supports and to cartridges, columns, and medical apparatuses comprising such derivatised solid supports.
    Type: Application
    Filed: April 19, 2018
    Publication date: February 13, 2020
    Applicant: SETLANCE S.R.L.
    Inventors: Alessandro Pini, Chiara Falciani, Luisa Bracci, Jlenia Brunetti, Leila Quercini
  • THERAPEUTIC COMBINATIONS FOR THE TREATMENT OF BACTERIAL INFECTIONS
    Publication number: 20190388494
    Abstract: There are disclosed therapeutic combinations of an antibacterial peptide and an antibiotic drug for use in the treatment of infections caused by Gram-negative pathogens, including bacterial strains resistant to common antibiotics. Also disclosed are pharmaceutical preparations and compositions containing the antibacterial peptide and antibiotics.
    Type: Application
    Filed: January 24, 2018
    Publication date: December 26, 2019
    Applicant: SETLANCE S.R.L.
    Inventors: Chiara Falciani, Alessandro Pini, Luisa Bracci, Jlenia Brunetti, GianMaria Rossolini, Simona Pollini
  • Antimicrobial peptide, branched forms thereof and their use in the treatment of bacteria infections
    Patent number: 8921308
    Abstract: The instant invention refers to an antibacterial peptide with all amino acids in D-configuration, possessing strong antimicrobial activity against Gram-negative and Gram-positive bacteria and Candida strains. The peptide can be in linear form multimerised on a skeleton of polyacrylamide, of dextrane units or on a skeleton of ethylene glycol units. The peptide is resistant proteolysis especially when synthesized in the tetra-branched form where identical peptide sequences are linked together by an appropriate molecular scaffold.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: December 30, 2014
    Assignee: Setlance S.R.L.
    Inventors: Alessandro Pini, Chiara Falciani, Luisa Bracci
  • ANTIBODIES OF THE ED-B DOMAIN OF FIBRONECTIN, THEIR CONSTRUCTION AND USES
    Publication number: 20140134182
    Abstract: According to the present invention there is provided a specific binding member which is specific for and binds directly to the ED-B oncofoetal domain of fibronectin (FN). The invention also provides materials and methods for the production of such binding members.
    Type: Application
    Filed: October 4, 2013
    Publication date: May 15, 2014
    Applicant: PHILOGEN S.P.A.
    Inventors: Dario NERI, Barbara CARNEMOLLA, Annalisa SIRI, Enrica BALZA, Patrizia CASTELLANI, Luciano ZARDI, Gregory Paul WINTER, Giovanni NERI, Laura BORSI, Alessandro PINI
  • ANTIMICROBIAL PEPTIDE, BRANCHED FORMS THEREOF AND THEIR USE IN THE TREATMENT OF BACTERIA INFECTIONS
    Publication number: 20130130969
    Abstract: The instant invention refers to an antibacterial peptide with all aminoacids in D-configuration, possessing strong antimicrobial activity against Gram-negative and Gram-positive bacteria and Candida strains. The peptide can be in linear form or multimerised on a skeleton of polyacrylamide, of dextrane units or on a skeleton of ethylene glycol units. The peptide is resistant to proteolysis especially when synthesized in the tetra-branched form where identical peptide sequences are linked together by an appropriate molecular scaffold.
    Type: Application
    Filed: July 11, 2011
    Publication date: May 23, 2013
    Applicant: SETLANCE S.R.L.
    Inventors: Alessandro Pini, Chiara Falciani, Luisa Bracci
  • Peptide sequences, their branched form and use thereof for antimicrobial applications
    Patent number: 8440794
    Abstract: The present invention relates to an antibacterial peptide having from the amino to the carboxylic terminal an amino acid sequences selected from the group of: KKIRVRLSA, SEQ ID NO. 1, RRIRVRLSA, SEQ ID NO. 2, KRIRVRLSA, SEQ ID NO. 3, RKIRVRLSA, SEQ ID NO. 4 or a derivative thereof and uses thereof.
    Type: Grant
    Filed: October 5, 2009
    Date of Patent: May 14, 2013
    Assignee: Universita' Degli Studi di Siena
    Inventors: Luisa Bracci, Chiara Falciani, Alessandro Pini
  • Antibacterial peptides and analogues thereof
    Patent number: 8268961
    Abstract: Antibacterial peptides and their multimeric analogues, with a wide range of action and low haemolytic activity are described. In particular, the peptide molecules exhibit a high antimicrobial activity against numerous bacterial species, with reduced cytotoxicity and a low haemolysis rate. The molecules of the invention are advantageously usable as therapeutic agents and coadjutants against infections caused by strains that are resistant to common antibiotics.
    Type: Grant
    Filed: July 13, 2005
    Date of Patent: September 18, 2012
    Assignee: Universita Degli Studi di Siena
    Inventors: Luisa Bracci, Andrea Giuliani, Alessandro Pini, Paolo Neri
  • NEUROTENSIN-DERIVED BRANCHED PEPTIDES AND USES THEREOF
    Publication number: 20110319339
    Abstract: The present invention relates to a multimeric molecule having the general formula A or B: and its use in the diagnosis and/or therapy of tumors.
    Type: Application
    Filed: November 4, 2009
    Publication date: December 29, 2011
    Inventors: Luisa Bracci, Alessandro Pini, Chiara Falciani, Stefano Menichetti
  • PEPTIDE SEQUNCES, THEIR BRANCHED FORM AND USE THEREOF FOR ANTIMICROBIAL APPLICATIONS
    Publication number: 20110190198
    Abstract: The present invention relates to an antibacterial peptide having from the amino to the carboxylic terminal an amino acid sequences selected from the group of: KKIRVRLSA, SEQ ID NO. 1, RRIRVRLSA, SEQ ID NO. 2, KRIRVRLSA, SEQ ID NO. 3, RKIRVRLSA, SEQ ID NO. 4 or a derivative thereof and uses thereof.
    Type: Application
    Filed: October 5, 2009
    Publication date: August 4, 2011
    Applicant: UNIVERSITÀ DEGLI STUDI DI SIENA
    Inventors: Luisa Bracci, Chiara Falciani, Alessandro Pini
  • Synthetic peptides containing the motif "YWWLXP" as anthrax toxin antidotes
    Publication number: 20090104214
    Abstract: Specific inhibitors, in Multiple Antigen Peptide form, which inhibit the interaction between protective antigen and lethal factor and neutralize anthrax toxin in vivo. Anti protective antigen peptides were selected from a phage library by competitive panning with lethal factor. Selected 12mer peptides were synthesized in tetra-branched form and systematically modified to achieve peptides with higher affinity and inhibitory efficiency.
    Type: Application
    Filed: March 25, 2005
    Publication date: April 23, 2009
    Inventors: Paolo Neri, Luisa Bracci, Alessandro Pini
  • Antibacterial peptides and analogues thereof
    Publication number: 20090053151
    Abstract: Antibacterial peptides and their multimeric analogues, with a wide range of action and low haemolytic activity are described. In particular, the peptide molecules exhibit a high antimicrobial activity against numerous bacterial species, with reduced cytotoxicity and a low haemolysis rate. The molecules of the invention are advantageously usable as therapeutic agents and coadjutants against infections caused by strains that are resistant to common antibiotics.
    Type: Application
    Filed: July 13, 2005
    Publication date: February 26, 2009
    Inventors: Luisa Bracci, Andrea Giuliani, Alessandro Pini, Paolo Neri
  • ANTIBODIES OF THE ED-B DOMAIN OF FIBRONECTIN, THEIR CONSTRUCTION AND USES
    Publication number: 20080274099
    Abstract: According to the present invention there is provided a specific binding member which is specific for and binds directly to the ED-B oncofoetal domain of fibronectin (FN). The invention also provides materials and methods for the production of such binding members.
    Type: Application
    Filed: August 21, 2007
    Publication date: November 6, 2008
    Inventors: Dario Neri, Barbara Carnemolla, Enrica Balza, Patrizia Castellani, Luciano Zardi, Gregory Paul Winter, Giovanni Neri, Laura Borsi, Alessandro Pini