Abstract: An integrated circuit device for reservoir computing can include a weighted input layer, an unweighted, asynchronous, internal recurrent neural network made up of nodes having binary weighting, and a weighted output layer. Weighting of output signals can be performed using predetermined weighted sums stored in memory. Application specific integrated circuit (ASIC) embodiments may include programmable nodes. Characteristics of the reservoir of the device can be tunable to perform rapid processing and pattern recognition of signals at relatively large rates.

Abstract: Processes for the synthesis and purification of glycoconjugate derivatives of cholic acid of formula (I) are provided herein.

Abstract: An integrated circuit device for reservoir computing can include a weighted input layer, an unweighted, asynchronous, internal recurrent neural network made up of nodes having binary weighting, and a weighted output layer. Weighting of output signals can be performed using predetermined weighted sums stored in memory. Application specific integrated circuit (ASIC) embodiments may include programmable nodes. Characteristics of the reservoir of the device can be tunable to perform rapid processing and pattern recognition of signals at relatively large rates.

Abstract: A variable sensitivity node for a neural network that can be implemented as an information processing device such as an ASIC, and can be adjusted simply by applying immediate weights or parameters that change and/or amplify or de-amplify the output of the nodes. The information processing device has one or more nodes each with an input setting channel, a logic element configured to translate the input signal into the output signal based on a mathematical function that includes a parameter setting, and a parameter-setting element configured to set the parameter setting based on a control input to the input setting channel, thereby altering the mathematical relationship of the logic element without compromising speed and efficiency.

Abstract: Processes for the synthesis and purification of glycoconjugate derivatives of cholic acid are provided herein.

Abstract: The present invention relates to a process for the preparation of selegiline base, an irreversible and selective inhibitor of the MAO-B enzymes and which is used in the treatment of Parkinson's Disease.

Abstract: The present invention relates to a process for the preparation of anhydrous crystalline 2-(R)-[(3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl]-1H-benzimidazole (dexlansoprazole).

Abstract: The present invention relates to a process for the preparation of anhydrous crystalline 2-(R)-[(3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)sulfinyl]-1H-benzimidazole (dexlansoprazole).

Abstract: The present invention relates to a process for the preparation of selegiline base, an irreversible and selective inhibitor of the MAO-B enzymes and which is used in the treatment of Parkinson's Disease.

Abstract: The present invention relates to a process for the preparation of pirfenidone, an immunosuppressive drug developed for the treatment of idiopathic pulmonary fibrosis.

Abstract: The present invention relates to a new process for the isolation and purification of 6-aminocaproic acid, which is a known inhibitor of enzymes responsible for fibrinolysis and is used in the treatment of coagulopathies and severe post-operative bleedings.

Abstract: The present invention relates to a new process for the isolation and purification of 6-aminocaproic acid, which is a known inhibitor of enzymes responsible for fibrinolysis and is used in the treatment of coagulopathies and severe post-operative bleedings.

Abstract: A photon detector article includes a photon detector configured to receive a primary waveform, the photon detector includes a multiplication region; a photon absorption region; a punch through voltage range; and a breakdown voltage; a source in electrical communication with the photon detector and configured to provide the primary waveform that includes a first voltage that is: less than a maximum value of the punch through voltage range, or effective to maintain a charge carrier in the absorption region; and a second voltage that is greater than the breakdown voltage; and a reference member in electrical communication with the source and configured to provide a reference waveform in response to receiving the primary waveform.

Abstract: A photon detector article includes a photon detector configured to receive a primary waveform, the photon detector includes a multiplication region; a photon absorption region; a punch through voltage range; and a breakdown voltage; a source in electrical communication with the photon detector and configured to provide the primary waveform that includes a first voltage that is: less than a maximum value of the punch through voltage range, or effective to maintain a charge carrier in the absorption region; and a second voltage that is greater than the breakdown voltage; and a reference member in electrical communication with the source and configured to provide a reference waveform in response to receiving the primary waveform.

Abstract: Process for the preparation of crystalline anhydrous (R)-2-[[[3-methyl-4-(2,2,2-trifluoroetoxy)-2-piridyl]methyl]sulphinyl]benzimidazole (dexlansoprazole).

Abstract: Rabeprazole sodium in the monohydrate crystalline form, pharmaceutical compositions thereof, the use thereof in therapy, a process for its preparation, and the use thereof for the purification of rabeprazole sodium.

Abstract: Process for the preparation of crystalline anhydrous (R)-2-[[[3-methyl-4-(2,2,2-trifluoroetoxy)-2-piridyl]methyl]sulphinyl]benzimidazole (dexlansoprazole).

Abstract: Rabeprazole sodium in the monohydrate crystalline form, pharmaceutical compositions thereof, the use thereof in therapy, a process for its preparation, and the use thereof for the purification of rabeprazole sodium.

Abstract: Supply system (10) for a silk-screen printing machine comprising a supply table (20) mobile on longitudinal guides (22) in a longitudinal advancing direction (F) of a sheet (12) able to be registered longitudinally through longitudinal registering means (60), the supply system (10) comprising transversal registering means (40) which comprise locking means (50) suitable for locking the sheet (12) on the supply table (20) for a predetermined time and an actuator (24) to move the supply table (20) in a direction transversal to the longitudinal direction (F) such as to allow the registering of the transversal position of the sheet (12) without misaligning it with respect to the longitudinal direction (F).