Patents by Inventor Alessandro Sisto

Alessandro Sisto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Linear basic compounds having NK-2 antagonist activity and formulations thereof
    Patent number: 7273856
    Abstract: Described herein are compounds of formula (I) useful as antagonists of tachykinins in general, and in particular of neurokinin A; and the pharmaceutical formulations comprising the compounds of formula (I)
    Type: Grant
    Filed: October 28, 2002
    Date of Patent: September 25, 2007
    Assignee: Menarini Ricerche S.P.A.
    Inventors: Alessandro Sisto, Valerio Caciagli, Maria Altamura, Alessandro Giolitti, Valentina Fedi, Antonio Guidi, Danilo Giannotti, Nicholas Harmat, Rossano Nannicini, Franco Pasqui, Carlo Alberto Maggi
  • Linear basic compounds having nk-2 antagonist activity and formulations thereof
    Publication number: 20040259930
    Abstract: Described herein are compounds of formula (I) useful as antagonists of tachykinins in general, and in particular of neurokinin A; and the pharmaceutical formulations comprising the compounds of formula (I) 1
    Type: Application
    Filed: April 29, 2004
    Publication date: December 23, 2004
    Inventors: Alessandro Sisto, Valerio Caciagli, Maria Altamura, Alessandro Giolitti, Valentina Fedi, Antonio Guidi, Danilo Giannotti, Nicholas Alberto Harmat, Rossano Nannicini, Franco Pasqui, Carlo Alberto Maggi
  • Tachykinins antagonists
    Patent number: 5849795
    Abstract: The present invention refers to tachykinins antagonists of general formula (I) ##STR1## their preparation and pharmaceutical compositions containing them.
    Type: Grant
    Filed: September 9, 1997
    Date of Patent: December 15, 1998
    Assignee: A Menarini Industrie Farmaceutiche Riunite S.r.l.
    Inventors: Alessandro Sisto, Edoardo Potier, Stefano Manzini, Christopher Fincham, Paolo Lombardi, Federico Arcamone
  • Tachykinin antagonists
    Patent number: 5760248
    Abstract: A description is given of tachykinin receptor antagonists having general formula (I) ##STR1## their preparation and use in pharmaceutical formulations.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: June 2, 1998
    Assignee: A.Menarini Industrie Farmaceutiche Riunite S.r.l.
    Inventors: Alessandro Sisto, Christopher Fincham, Edoardo Potier, Stefano Manzini, Federico Arcamone, Paolo Lombardi
  • Tachykinins antagonists
    Patent number: 5698710
    Abstract: The present invention refers to tachykinins antagonists of general formula (I) ##STR1## their preparation and pharmaceutical compositions containing them.
    Type: Grant
    Filed: July 8, 1996
    Date of Patent: December 16, 1997
    Assignee: A. Menarini Industrie Farmaceutiche Riunite S.r.l.
    Inventors: Alessandro Sisto, Edoardo Potier, Stefano Manzini, Christopher Fincham, Paolo Lombardi, Federico Arcamone
  • Tachyquinine antagonists, their preparation and use in pharmaceutical formulations
    Patent number: 5641802
    Abstract: A description is given of tachyquinine antagonists having general formula (I) ##STR1## their preparation and use in pharmaceutical formulations.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: June 24, 1997
    Assignees: A. Menarini Industrie Farmaceutiche Reiunite S.r.l., Malesci Istituto Farmacobiologico S.p.A.
    Inventors: Federico Arcamone, Paolo Lombardi, Stefano Manzini, Edoardo Potier, Alessandro Sisto
  • Retro-inverso analogues of thymopentin and the method for their synthesis
    Patent number: 5218089
    Abstract: New analogues of thymopentin (TP5) and of its tetrapeptide fragment (TP5.sup.1-4) containing two non-contiguous retro-inverted bonds in the peptide chain are described which are of the general formula (I) ##STR1## where R is hydrogen or an acyl radical, and R.sup.1 is an --OR.sup.2 group or an ##STR2## group where R.sup.2 is a hydrogen atom or a hydrocarbon radical, and R.sup.3 is a hydrogen atom or a hydroxyl group, and the corresponding pharmaceutically acceptable salts of acid or basic addition, possess immunomodulating activity.
    Type: Grant
    Filed: November 26, 1991
    Date of Patent: June 8, 1993
    Assignee: Sclavo S.p.A.
    Inventors: Sabina Mariotti, Alessandro Sisto, Luciano Nencioni, Luigi Villa, Antonio S. Verdini
  • Process for preparing new thymopentin retro-inverso analogs and fragments thereof and the intermediates obtained therein
    Patent number: 5200506
    Abstract: New retro-inverso analogs of thymopentin (TP5) and of its tripeptide fragment (TP5.sup.1-3) of general formula (I) ##STR1## are described wherein R is hydrogen or an acyl radical, and R.sup.1 is --OR.sup.2 or ##STR2## wherein R.sup.2 is hydrogen or a hydrocarbyl radical, and the corresponding pharmaceutically acceptable acid- or base-addition salts. A process of preparing the tripeptide fragment of formula I is also described.The new compounds are enzyme-resistant immunomodulatory peptides.
    Type: Grant
    Filed: January 31, 1991
    Date of Patent: April 6, 1993
    Assignees: Eniricerche S.p.A., Sclavo S.p.A.
    Inventors: Alessandro Sisto, Antonio S. Verdini
  • Retro-inverso analogues of thymopentin, and their use in the preparation of pharmaceutical compositions
    Patent number: 5091510
    Abstract: New analogues of thymopentin (TP5) and of its tetrapeptide fragment (TP5.sup.1-4) containing two non-contiguous retro-inverted bonds in the peptide chain are described.The new compounds, of general formula (I) ##STR1## where R is hydrogen or an acyl radical, andR.sup.1 is an --OR.sup.2 group or an ##STR2## group where R.sup.2 is a hydrogen atom or a hydrocarbon radical, and R.sup.3 is a hydrogen atom or a hydroxyl group,and the corresponding pharmaceutically acceptable salts of acid or basic addition, possess immunomodulating activity.
    Type: Grant
    Filed: December 21, 1989
    Date of Patent: February 25, 1992
    Assignee: Scalvo, S.p.A.
    Inventors: Sabina Mariotti, Alessandro Sisto, Luciano Nencioni, Luigi Villa, Antonio S. Verdini
  • Tripeptide compounds having hypotensive activity
    Patent number: 5051404
    Abstract: Tripeptides having hypotensive activity, defined by the following general formula:A--B--C--OZ (I)wherein:A represents a residue of L-pyroglutamic acid, L-proline of L-proline bearing a substituent on its amino group ##STR1## wherein R.sub.1 is an acyl with a number of carbon atoms in straight chain not higher than 9, a benzyloxycarbonyl group or an alkyloxycarbonyl group;B is an .alpha.-aminoacide residue derived from one of the natural aminoacids;C is a residue of L-tryptophan (Trp), of L-phenylalanine (Phe) or of L-tyrosine (Tyr);Z is a hydrogen atom or an alkyl group with a number of carbon atoms in straight chain not higher than 9.
    Type: Grant
    Filed: September 20, 1988
    Date of Patent: September 24, 1991
    Assignees: Eniricerche, S.p.A., Polifarma, S.p.A.
    Inventors: Alessandro Sisto, Antonio S. Verdini, Antonino Virdia, Giovanna De Luca, Giovanni Di Stazio, Vincenzo Politi
  • New thymopentin retro-inverso analogs and fragments thereof, a process of preparation of the new compounds and the intermediates obtained therein
    Patent number: 5013723
    Abstract: New retro-inverso analogs of thymopentin (TP5) and of its tripeptide fragment (TP5.sup.1-3) of general formula (I) ##STR1## are described wherein R is hydrogen or an acyl radical, and R.sup.1 is --OR.sup.2 or ##STR2## wherein R.sup.2 is hydrogen or a hydrocarbyl radical, and the corresponding pharmaceutically acceptable acid- or base-addition salts.The new compounds are enzyme-resistant immunomodulatory peptides.
    Type: Grant
    Filed: March 15, 1988
    Date of Patent: May 7, 1991
    Assignees: Eniricerche S.p.A., Sclavo S.p.A.
    Inventors: Alessandro Sisto, Antonio Verdini
  • Pharmacologically active tripeptides and process for their synthesis
    Patent number: 4748155
    Abstract: Pharmacologically active tripeptides, with at least a retro-inverted peptidic bond, definable by means of the following general formulae: ##STR1## their pharmaceutically acceptable salts, esters or alkyl amides, whereinR.sub.1 represents a hydrogen atom, an alkyl group with a maximum of 7 carbon atoms, an aryl, hydroxyalkyl or hydroxyarylalkyl, guanidylalkyl, amino-alkyl, alkyl-oxy-alkyl, acylamino-alkyl, imidazolylalkyl, indolyl-alkyl, mercapto alkyl, alkylmercaptoalkyl, carbamoyl-alkyl, carboxyalkyl, alkyl-carbamoylalkyl or alkyloxy-carbonylalkyl group;R.sub.2 represents a ##STR2## group, Z is an OH, OR.sub.3, NH.sub.2, NHR.sub.3 group, whereinR.sub.3 represents an alkyl group with a number of carbon atoms comprised within the range of from 1 to 10.
    Type: Grant
    Filed: March 10, 1986
    Date of Patent: May 31, 1988
    Assignees: Eniricerche S.p.A., Polifarma S.p.A.
    Inventors: Alessandro Sisto, Antonio S. Verdini, Antonio Virdia, Giovanna De Luca, Giovanni Di Stazio, Vincenzo Politi
  • Retro-inverted peptides analogues of Bradykinin Potentiator BPP.sub.5a
    Patent number: 4728725
    Abstract: Retro-inverted peptides, analogues of Bradykinin Potentiator Pentapeptide (BPP.sub.5a), definable by the general formula (I) ##STR1## useful as antihypertensives and diagnostics.
    Type: Grant
    Filed: December 20, 1985
    Date of Patent: March 1, 1988
    Assignees: Enichem, S.p.A., Eniricerche, S.p.A.
    Inventors: Alessandro Sisto, Antonio S. Verdini, Antonino Virdia
  • Retro-inverso analogs of the bradykinin potentiating peptide BPP.sub.5a
    Patent number: 4713367
    Abstract: New partially retro-inverso peptides of the following general formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and represent, each independently, the side chain of the aminoacid residues present in the naturally occuring peptides, X is --S--Ph or --O--CH.sub.2 --Ph and Z is a hydroxy, alkoxy or amino group, are described as well as a suitable method for their preparation. The new compounds are useful as antihypertensive agents.
    Type: Grant
    Filed: January 22, 1986
    Date of Patent: December 15, 1987
    Assignee: Enichem S.p.A.
    Inventors: Alessandro Sisto, Antonio S. Verdini, Antonino Virdia
  • Peptido-mimetic substances with hypotensive action
    Patent number: 4713368
    Abstract: Peptido-mimetic compounds of hypotensive action definable by the general formula: ##STR1## in which: X represents the pyroglutamic acid residue or a ##STR2## residue where R.sub.2 represents a hydrogen atom, an alkyloxycarbonyl, an arylalkyloxycarbonyl or an acyl group with from 1 to 7 carbon atoms in the linear chain,R.sub.1 represents the aromatic residue of L-phenylalanine, L-tyrosine or L-tryptophan, andZ represents a hydroxyl, hydroxyalkyl, amino or alkylamino group, and their salts and alkyl amides or esters.
    Type: Grant
    Filed: July 17, 1986
    Date of Patent: December 15, 1987
    Assignees: Eniricerche S.p.A., Polifarma S.p.A.
    Inventors: Alessandro Sisto, Antonio S. Verdini, Antonino Virdia, Giovanna De Luca, Giovanni Di Stazio, Vincenzo Politi
  • Retro-inverso analogues of the bradykinin potentiating peptide BPP.sub.5a and methods for their preparation
    Patent number: 4522752
    Abstract: This invention relates to new retro-inverso peptides and peptide derivatives in the form of analogues of the bradykinin potentiating peptide (BPP.sub.
    Type: Grant
    Filed: May 10, 1984
    Date of Patent: June 11, 1985
    Assignee: E.N.I. Ente Nazionale Idrocarburi
    Inventors: Alessandro Sisto, Antonio S. Verdini, Antonino Virdia