Patents by Inventor Alex Franzusoff

Alex Franzusoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER USING A TGFßRII ENGINEERED T CELL THERAPY
    Publication number: 20240066063
    Abstract: Compositions comprising and methods for the treatment of cancer using a NeoTCR based cell therapy with a modified TGF?RII expression.
    Type: Application
    Filed: May 18, 2023
    Publication date: February 29, 2024
    Applicant: PACT PHARMA, INC.
    Inventors: Charles W. TRAN, John D. Gagnon, Barbara Sennino, Stefanie Mandl-Cashman, Kyle Jacoby, William Lu, Michael Mayne Dubreuil, James S. Byers, III, Michal Mass, Alex Franzusoff
  • METHODS OF TREATMENT USING A GENETICALLY MODIFIED AUTOLOGOUS T CELL IMMUNOTHERAPY
    Publication number: 20240016844
    Abstract: Methods of treating cancer with a precision genome engineered NeoTCR Product are described herein.
    Type: Application
    Filed: June 9, 2023
    Publication date: January 18, 2024
    Applicant: PACT PHARMA, INC.
    Inventors: Barbara Sennino, Bhamini Purandare, Stefanie Mandl-Cashman, Gregg D. Fine, Arati V. Rao, Todd Stallings-Schmitt, Mark Walter Frohlich, Alex Franzusoff
  • Combination Immunotherapy Compositions Against Cancer and Methods
    Publication number: 20230256067
    Abstract: Disclosed are immunotherapeutic compositions and the concurrent use of combinations of such compositions for the improved induction of therapeutic immune responses and/or for the prevention, amelioration and/or treatment of disease, including, but not limited to, cancer and infectious disease.
    Type: Application
    Filed: January 24, 2023
    Publication date: August 17, 2023
    Inventors: James Hodge, Jeffrey Schlom, Alex Franzusoff
  • COMPOSITIONS AND METHODS FOR IDENTIFICATION OF ANTIGEN SPECIFIC T CELLS
    Publication number: 20230194504
    Abstract: Disclosed herein are antigenic peptide-MHC complexes, termed comPACT polypeptides and comPACT polynucleotides, and methods of producing such complexes. Also discloses herein are methods of producing libraries of comPACT polynucleotides and polypeptides, and their exemplary use in capturing cancer neoepitope-reactive T cells with high accuracy. Dual particle detection approaches for detection of neoantigen specific T cells with improved sensitivity and specificity are provided. Signal to noise ratio analysis of isolated T cells for detection of neoantigen-specific T cells with improved T cells is also provided.
    Type: Application
    Filed: October 28, 2022
    Publication date: June 22, 2023
    Applicant: PACT PHARMA, INC.
    Inventors: Songming Peng, Boi Bryant Quach, Duo An, Xiaoyan Robert Bao, Alex Franzusoff, Barbara Sennino, Olivier Dalmas, Stefanie Mandl-Cashman
  • Combination immunotherapy compositions against cancer and methods
    Patent number: 11596675
    Abstract: Disclosed are immunotherapeutic compositions and the concurrent use of combinations of such compositions for the improved induction of therapeutic immune responses and/or for the prevention, amelioration and/or treatment of disease, including, but not limited to, cancer and infectious disease.
    Type: Grant
    Filed: November 18, 2020
    Date of Patent: March 7, 2023
    Assignees: GlobeImmune, Inc., The USA, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: James Hodge, Jeffrey Schlom, Alex Franzusoff
  • Combination immunotherapy compositions against cancer and methods
    Patent number: 11590216
    Abstract: Disclosed are immunotherapeutic compositions and the concurrent use of combinations of such compositions for the improved induction of therapeutic immune responses and/or for the prevention, amelioration and/or treatment of disease, including, but not limited to, cancer and infectious disease.
    Type: Grant
    Filed: December 22, 2020
    Date of Patent: February 28, 2023
    Assignees: GlobelImmune, Inc., The USA, as represented by the Secretary, Dept, of Health and Human Services
    Inventors: James Hodge, Jeffrey Schlom, Alex Franzusoff
  • Compositions and methods for identification of antigen specific T cells
    Patent number: 11513113
    Abstract: Disclosed herein are antigenic peptide-MHC complexes, termed comPACT polypeptides and comPACT polynucleotides, and methods of producing such complexes. Also discloses herein are methods of producing libraries of comPACT polynucleotides and polypeptides, and their exemplary use in capturing cancer neoepitope-reactive T cells with high accuracy. Dual particle detection approaches for detection of neoantigen specific T cells with improved sensitivity and specificity are provided. Signal to noise ratio analysis of isolated T cells for detection of neoantigen-specific T cells with improved T cells is also provided.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: November 29, 2022
    Assignee: PACT PHARMA, INC.
    Inventors: Songming Peng, Boi Bryant Quach, Duo An, Xiaoyan Robert Bao, Alex Franzusoff, Barbara Sennino, Olivier Dalmas, Stefanie Mandl-Cashman
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER USING A CD8 ENGINEERED T CELL THERAPY
    Publication number: 20220193139
    Abstract: Compositions comprising and methods for the treatment of cancer using a neoTCR based cell therapy with a CD8 expression construct.
    Type: Application
    Filed: March 10, 2022
    Publication date: June 23, 2022
    Applicant: PACT PHARMA, INC.
    Inventors: Barbara Sennino, Kyle Jacoby, Stefanie Mandl-Cashman, Michael M. Dubreuil, John Gagnon, Alex Franzusoff
  • Compositions and methods for the treatment of cancer using a CD8 engineered T cell therapy
    Patent number: 11304978
    Abstract: Compositions comprising and methods for the treatment of cancer using a neoTCR based cell therapy with a CD8 expression construct.
    Type: Grant
    Filed: November 20, 2020
    Date of Patent: April 19, 2022
    Assignee: PACT PHARMA, INC.
    Inventors: Barbara Sennino, Kyle Jacoby, Stefanie Mandl-Cashman, Michael M. Dubreuil, John Gagnon, Alex Franzusoff
  • PRIMARY CELL GENE EDITING
    Publication number: 20210395783
    Abstract: Methods and compositions are provided for nuclease-mediated gene editing of primary cells without the use of viral mediated delivery. Methods of treatments using edited primary cells are also provided.
    Type: Application
    Filed: August 12, 2021
    Publication date: December 23, 2021
    Applicant: PACT PHARMA, INC.
    Inventors: Kyle Jacoby, Alex Franzusoff
  • ANTIGEN SPECIFIC TCR IDENTIFICATION USING SINGLE-CELL SORTING
    Publication number: 20210230544
    Abstract: Compositions and methods for identifying antigen-specific T cells, including determining paired T cell receptor sequences for a specific antigen, are described. Compositions and methods for identifying neoantigen-specific T cells are also described.
    Type: Application
    Filed: March 15, 2021
    Publication date: July 29, 2021
    Applicant: PACT PHARMA, INC.
    Inventors: Songming Peng, Alex Franzusoff
  • Yeast-MUC1 immunotherapeutic compositions and uses thereof
    Patent number: 11065318
    Abstract: Disclosed are yeast-based immunotherapeutic compositions comprising mucin-1 (MUC1), as well as methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of mucin-1 (MUC1).
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: July 20, 2021
    Assignees: GlobeImmune, Inc., The USA, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: Alex Franzusoff, Zhimin Guo, Jeffrey Schlom, Kwong-Yok Tsang
  • METHODS OF TREATMENT USING A GENETICALLY MODIFIED AUTOLOGOUS T CELL IMMUNOTHERAPY
    Publication number: 20210205363
    Abstract: Methods of treating cancer with a precision genome engineered NeoTCR Product are described herein.
    Type: Application
    Filed: November 16, 2020
    Publication date: July 8, 2021
    Applicant: PACT PHARMA, INC.
    Inventors: Barbara Sennino, Bhamini Purandare, Stefanie Mandl-Cashman, Gregg D. Fine, Arati V. Rao, Todd Stallings-Schmitt, Mark Walter Frohlich, Alex Franzusoff
  • Combination Immunotherapy Compositions Against Cancer and Methods
    Publication number: 20210113677
    Abstract: Disclosed are immunotherapeutic compositions and the concurrent use of combinations of such compositions for the improved induction of therapeutic immune responses and/or for the prevention, amelioration and/or treatment of disease, including, but not limited to, cancer and infectious disease.
    Type: Application
    Filed: December 22, 2020
    Publication date: April 22, 2021
    Inventors: James Hodge, Jeffrey Schlom, Alex Franzusoff
  • METHOD OF TREATING IMMUNOTHERAPY NON-RESPONDERS WITH AN AUTOLOGOUS CELL THERAPY
    Publication number: 20210106621
    Abstract: Methods of treating cancer in Non-Responder Patients with an engineered NeoTCR Product are described herein.
    Type: Application
    Filed: October 9, 2020
    Publication date: April 15, 2021
    Applicant: PACT Pharma, Inc.
    Inventors: Barbara Sennino, Songming Peng, Stefanie Mandl-Cashman, Alex Franzusoff
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER USING A TET2 ENGINEERED T CELL THERAPY
    Publication number: 20210085720
    Abstract: Compositions comprising and methods for the treatment of cancer using a neoTCR based cell therapy with a knockout of the expression of the TET2 gene.
    Type: Application
    Filed: November 16, 2020
    Publication date: March 25, 2021
    Applicant: PACT PHARMA, INC.
    Inventors: Barbara Sennino, Kyle Jacoby, Stefanie Mandl-Cashman, Michael M. Dubreuil, John Gagnon, Alex Franzusoff
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER USING A CD8 ENGINEERED T CELL THERAPY
    Publication number: 20210085721
    Abstract: Compositions comprising and methods for the treatment of cancer using a neoTCR based cell therapy with a CD8 expression construct.
    Type: Application
    Filed: November 20, 2020
    Publication date: March 25, 2021
    Applicant: PACT PHARMA, INC.
    Inventors: Barbara Sennino, Kyle Jacoby, Stefanie Mandl-Cashman, Michael M. Dubreuil, John Gagnon, Alex Franzusoff
  • Combination Immunotherapy Compositions Against Cancer and Methods
    Publication number: 20210069308
    Abstract: Disclosed are immunotherapeutic compositions and the concurrent use of combinations of such compositions for the improved induction of therapeutic immune responses and/or for the prevention, amelioration and/or treatment of disease, including, but not limited to, cancer and infectious disease.
    Type: Application
    Filed: November 18, 2020
    Publication date: March 11, 2021
    Inventors: James Hodge, Jeffrey Schlom, Alex Franzusoff
  • Combination immunotherapy compositions against cancer and methods
    Patent number: 10874729
    Abstract: Disclosed are immunotherapeutic compositions and the concurrent use of combinations of such compositions for the improved induction of therapeutic immune responses and/or for the prevention, amelioration and/or treatment of disease, including, but not limited to, cancer and infectious disease.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: December 29, 2020
    Assignees: GlobeImmune, Inc., The USA, as represented by the Secretary, Dept of Health and Human Services
    Inventors: James Hodge, Jeffrey Schlom, Alex Franzusoff
  • PRIMARY CELL GENE EDITING
    Publication number: 20200299730
    Abstract: Methods and compositions are provided for nuclease-mediated gene editing of primary cells without the use of viral mediated delivery. Methods of treatments using edited primary cells are also provided.
    Type: Application
    Filed: June 4, 2020
    Publication date: September 24, 2020
    Applicant: PACT PHARMA, INC.
    Inventors: Kyle Jacoby, Alex Franzusoff