Abstract: A method for spatially tagging nucleic acids of a biological specimen, including steps of (a) providing a solid support comprising different nucleic acid probes that are randomly located on the solid support, wherein the different nucleic acid probes each includes a barcode sequence that differs from the barcode sequence of other randomly located probes on the solid support; (b) performing a nucleic acid detection reaction on the solid support to locate the barcode sequences on the solid support; (c) contacting a biological specimen with the solid support that has the randomly located probes; (d) hybridizing the randomly located probes to target nucleic acids from portions of the biological specimen; and (e) modifying the randomly located probes that are hybridized to the target nucleic acids, thereby producing modified probes that include the barcode sequences and a target specific modification, thereby spatially tagging the nucleic acids of the biological specimen.

Abstract: Methods and techniques to implement a digital signal processor for avoidance of audio feedback are disclosed, in particular, audio signal processing systems that reduce the requirement for physical segregation of sound acquisition and diffusion zones. In a more general aspect, the components and techniques described herein provide a for a sound space and sound processing equipment such that sound travelling electronically in a loop through the sound processing equipment that is output into a physical sound diffusion zone, received at the input to the sound processing equipment, and then re-amplified, etc. is attenuated over that loop by frequency modification. The frequency modification is such that, at least for some signals, on each pass through the loop, the sound processing equipment will attenuate or amplify individual sub-bands of the frequency spectrum of the audio signal that is received at the input of the sound processing equipment.

Abstract: A system comprises a source providing video in a first format, a video converter for converting video from the first to a second format, a server storing a video image from the video, and combining the video image with a graphical user interface to form a composite video, and a first user display device displaying the composite video, and receiving from the user, a plurality of commands, wherein the first user display device is for receiving from the user, a plurality of annotations associated with a video frame from the composite video, and for determining the video frame from the composite video in response to a command, wherein the server is for forming an annotated video in response to the video frame and the plurality of annotations, for storing the plurality of annotations and the video frame, and for associating the plurality of annotations and the video frame.

Abstract: A system comprises a source providing video in a first format, a video converter for converting video form the first to a second format, a server storing a video image from the video, and combining the video image with a graphical user interface to form a composite video, and a first user display device displaying the composite video, and receiving from the user, a plurality of commands, wherein the first user display device is for receiving from the user, a plurality of annotations associated with a video frame from the composite video, and for determining the video frame from the composite video in response to a command, wherein the server is for forming an annotated video in response to the video frame and the plurality of annotations, for storing the plurality of annotations and the video frame, and for associating the plurality of annotations and the video frame.