Patents by Inventor Alex Stenzler
Alex Stenzler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230390327Abstract: The present invention relates to a liquid nitric oxide releasing solution (NORS) comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of nitric oxide gas (gNO). The present invention also relates to a liquid NORS comprised of at least one nitrite compound having a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment of a wound in a human, the method comprising administering to the human a liquid NORS comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of gNO.Type: ApplicationFiled: June 7, 2023Publication date: December 7, 2023Inventors: Alex Stenzler, Christopher C. Miller, Gilly Regev
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Patent number: 11707432Abstract: A method of controlling or electing the harshness of inhaled nicotine powder formulations is described. The method includes the steps of identifying a concentration of nicotine for a subject to inhale to achieve a desired level of harshness per inhalation, identifying the total dose of nicotine to be inhaled by the subject, and providing the subject with an amount of a formulation comprising nicotine particles having the identified concentration of nicotine, such that the total amount of nicotine particles in the formulation equals the total dose of nicotine.Type: GrantFiled: July 25, 2019Date of Patent: July 25, 2023Assignee: Philip Morris Products S.A.Inventors: Alex Stenzler, Noe Zamel, Arthur Slutsky, Steven Ellis, Steve Han
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Publication number: 20230201507Abstract: A nasal interface is provided that can allow for delivery of flow of a gas to a patient for respiratory support while preventing injury or irritation to the patient. The nasal interface can include a nasal pillow set having a nasal pillow, which can engage against a nose, and relief port, which can permit a gas to be released from the nasal interface. A nasal cannula can include a cannula body to direct a gas through the nasal interface, and can have an opening to direct a gas out of the cannula body. The gas can be directed from the cannula body, through the opening, toward a nasal pillow and a patient's nare. The nasal interface can be coupled with a head harness, which can be worn on the patient's head, and can include a guide that extends toward the nasal interface.Type: ApplicationFiled: March 7, 2023Publication date: June 29, 2023Inventors: Alex STENZLER, Steve HAN
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Patent number: 11672441Abstract: A spirometer turbine assembly is described, having a housing with a proximal end opening, a distal end opening and an airflow channel therebetween. A first flow director has a first plurality of flow director blades with distal edges that curve in a plane perpendicular to a longitudinal axis of the airflow channel, and a vane is connected to an axel positioned distal to the first flow director. A spirometer turbine assembly having an anti-static material is also described.Type: GrantFiled: December 11, 2020Date of Patent: June 13, 2023Assignee: Monitored Therapeutics, inc.Inventor: Alex Stenzler
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Patent number: 11638798Abstract: A nasal interface is provided that can allow for delivery of flow of a gas to a patient for respiratory support while preventing injury or irritation to the patient. The nasal interface can include a nasal pillow set having a nasal pillow, which can engage against a nose, and relief port, which can permit a gas to be released from the nasal interface. A nasal cannula can include a cannula body to direct a gas through the nasal interface, and can have an opening to direct a gas out of the cannula body. The gas can be directed from the cannula body, through the opening, toward a nasal pillow and a patient's nare. The nasal interface can be coupled with a head harness, which can be worn on the patient's head, and can include a guide that extends toward the nasal interface.Type: GrantFiled: October 12, 2017Date of Patent: May 2, 2023Assignee: Vyaire Medical Capital, LLCInventors: Alex Stenzler, Steve Han
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Patent number: 11389471Abstract: The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack.Type: GrantFiled: July 1, 2019Date of Patent: July 19, 2022Assignee: Proterris Inc.Inventors: Jeffrey D. Wager, Joseph Wager, Alex Stenzler, David Pinsky, Augustine Choi
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Patent number: 11324901Abstract: The present invention provides devices for holding one or more vapor sources in a media inhaler. The devices permit vapor from the one or more vapor sources to be introduced and entrained into a stream of inhaled media. The vapor insert device includes a hollow cylinder having a porous surface, an open anterior end, and an open posterior end. An anterior flange is attached to the open anterior end, and a posterior flange is attached to the open posterior end. The anterior flange and the posterior flange each have a diameter that is larger than a diameter of the hollow cylinder to form a circumferential space around the hollow cylinder.Type: GrantFiled: August 8, 2018Date of Patent: May 10, 2022Assignee: Philip Morris Products S.A.Inventors: Alex Stenzler, Steve Han, James Tibbatts, Steven Ellis
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Publication number: 20220126034Abstract: My powder inhalers are described. The dry powder inhaler includes an air inlet, a reservoir and an airway assembly. A mouthpiece airway is connected to a first airway of the airway assembly. An airway head is attached to the airway assembly and it extends into the reservoir cavity. In certain embodiments, the airway head has a sharpened or beveled edge. At least one airway assembly opening is present in the airway assembly for connecting the reservoir cavity to the first airway. Methods for dispensing dry powder into an airway of a dry powder inhaler and inhaling dry powder from a dry powder inhaler is also disclosed. Embodiments of a dry powder inhaler having a two-stage air movement are also described.Type: ApplicationFiled: January 13, 2020Publication date: April 28, 2022Applicant: PHILIP MORRIS PRODUCTS S.A.Inventors: Robin Craig Cocker, Christopher Iain Davidson, Steve Han, Ben Alexander King, Paul Mutti, Alex Stenzler, James Tibbatts
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Patent number: 11305073Abstract: A nebulizer device includes an air intake port positioned downstream of a nebulizer element, and a mouthpiece positioned upstream of the nebulizer element. A flow sensor is coupled to a controller. The controller is configured to integrate an inhaled air flow signal received from the flow sensor for determining an inhaled air volume. The controller is also configured to turn on the nebulizer element when the inhaled air volume reaches a first predetermined threshold, and turn off the nebulizer element when the inhaled air volume reaches a second predetermined threshold. A method for targeted delivery of aerosolized particles to the lungs is also disclosed.Type: GrantFiled: February 7, 2019Date of Patent: April 19, 2022Assignee: Monitored Therapeutics, IncInventors: Alex Stenzler, Steve Han, Martin Stegenga
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Patent number: 11298481Abstract: A system for monitoring inspirable gas for delivery to a patient includes a branched breathing circuit having a first branch conduit and a second branch conduit. The first branch conduit is fluidly connected to a first gas source and the second branch conduit is fluidly connected to a second gas source, and the first and second branch conduits merge into a patient delivery conduit. The system includes a first flow sensor in the first branch conduit, a second flow sensor in the second branch conduit, and a third flow sensor in the patient delivery conduit. A control unit is electrically coupled to the first, second and third flow sensors. The control unit is configured to determine a blend of gas in the patient delivery circuit based on a measured flow from the third flow sensor and a measured flow from at least one of the first and second flow sensors.Type: GrantFiled: September 16, 2016Date of Patent: April 12, 2022Assignee: 12th Man Technologies, Inc.Inventors: Steve Han, Alex Stenzler, Martin Stegenga
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Patent number: 11259908Abstract: A veterinary subject intranasal administration device includes a first support member portion including a septum interface portion sized for insertion into a nasal passage of the veterinary subject; an actuation mechanism connected to the first support member portion; and a fluid conduit having a distal end opposite a supported end, the distal end sized for insertion into the nasal passage of the veterinary subject, the fluid conduit being flexible and configured to receive fluid from a fluid source and discharge the fluid through the distal end into the nasal passage, the distal end of the fluid conduit being unsupported and movable relative to the septum interface portion.Type: GrantFiled: July 19, 2017Date of Patent: March 1, 2022Inventors: Amy L. Marr, Jane Granville Owens, Jeffrey Kyle Hill, Casey J. Strange, Randall Lee Waln, Christopher C. Miller, Gilly Regev-Shoshani, Alex Stenzler, Steve Han
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Patent number: 11229757Abstract: A dry powder inhaler dispenses a partial dosage of a powder from a dry powder chamber during a single user inhalation. In certain embodiments, the dry powder chamber is a dry powder capsule that spins in a chamber with a protrusion for limiting the spin of the capsule. In certain embodiments, a capsule slides in a proximal and distal direction for dispensing partial dosages of powder medicament. Air inlets in communication whit the external environment can be included in the inhaler housing for generating a smooth inhalation experience for the user and facilitating operation of partial dosage mechanisms. In other embodiments, a hinged member, sliding member, rotating member, spring tensioned member, pressure actuated valve, dry powder chamber with patterned holes or combinations of these are used as a mechanism for dispensing a partial dosage of powder medicament during a single inhalation.Type: GrantFiled: April 13, 2016Date of Patent: January 25, 2022Assignee: Philip Morris Products S.A.Inventors: Alex Stenzler, Steve Han, Arthur Slutsky, Steven Ellis, Noe Zamel, William Alston
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Publication number: 20220015693Abstract: A spirometry coaching system and method is described. The system includes a spirometer comprising at least one detection element, a patient interactive display, and a control unit communicatively connected to the detection element and the patient interactive display, wherein the control unit directs an audio and visual presentation of at least one test instruction on the patient interactive display, and wherein the control unit directs an audio and visual presentation of at least one test result on the patient interactive display based on a measurement received from the at least one detection element.Type: ApplicationFiled: September 29, 2021Publication date: January 20, 2022Inventor: Alex Stenzler
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Patent number: 11224594Abstract: A method of reducing nicotine cravings is described. The method includes inhalation of a dry powder formulation containing a dose of nicotine by a subject seeking nicotine cravings reduction. The formulation includes amounts and concentrations of nicotine that are significantly lower than cigarettes or nicotine replacement therapies.Type: GrantFiled: September 16, 2015Date of Patent: January 18, 2022Assignee: Philip Morris Products S.A.Inventors: Alex Stenzler, Noe Zamel, Arthur Slutsky, Steven Ellis, Steve Han
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Publication number: 20210402113Abstract: The present invention provides dry powder inhaler (DPI) devices (100) for dispensing dry powder and methods for using the same. The DPI devices feature vortex mechanisms for directing air in a turbulent manner sufficient to entrain an amount of a dry powder dose for delivery into a user's lungs. The DPI devices feature replaceable dry powder cartridges (200). The DPI devices also feature a retractable configuration for storage and for accidental dispensing of dry powder. The DPI devices dispense dry powder in controlled dosages.Type: ApplicationFiled: January 13, 2020Publication date: December 30, 2021Applicant: PHILIP MORRIS PRODUCTS S.A.Inventors: Robin Craig Cocker, Ben Alexander King, Christopher Iain Davidson, Paul Mutti, Alex Stenzler, Steve Han, James Tibbatts
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Publication number: 20210308175Abstract: The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack.Type: ApplicationFiled: June 16, 2021Publication date: October 7, 2021Applicant: Proterris Inc.Inventors: Jeffrey D. Wager, Joseph Wager, Alex Stenzler, David Pinsky, Augustine Choi
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Publication number: 20210252043Abstract: The present invention relates to a liquid nitric oxide releasing solution (NORS) comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of nitric oxide gas (gNO). The present invention also relates to a liquid NORS comprised of at least one nitrite compound having a concentration of no greater than about 0.5% w/v and at least one acidifying agent, wherein the NORS releases a therapeutically effective amount of gNO. The present invention also relates to a method for the treatment of a wound in a human, the method comprising administering to the human a liquid NORS comprised of at least one nitric oxide releasing compound and at least one acidifying agent, wherein the NORS provides an extended release of a therapeutically effective amount of gNO.Type: ApplicationFiled: February 1, 2021Publication date: August 19, 2021Applicant: SaNOtize Research and Development Corp.Inventors: Alex Stenzler, Christopher C. Miller, Gilly Regev
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Patent number: 11090448Abstract: A device for accessing dry powder within a sealed chamber is described. The device includes a hollow housing having a proximal end opening, a primary distal end opening and a secondary distal end opening, at least one wing structure extending from the outer surface of the housing that is positioned distally from the primary distal opening. Also described is a dry powder inhaler having a housing, a penetrating component for accessing dry powder within a sealed chamber, and a mouthpiece, where the mouthpiece is connected to the proximal end opening of the penetrating component, and wherein the at least a portion of the distal end of the penetrating component is positioned within the inhaler housing.Type: GrantFiled: April 13, 2016Date of Patent: August 17, 2021Assignee: Philip Morris Products S.A.Inventors: Alex Stenzler, Steve Han, Arthur Slutsky, Steven Ellis, Noe Zamel, William Alston
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Publication number: 20210220584Abstract: A split passageway resuscitation training device is described. Embodiments of the split passageway resuscitation training device can be implemented with a cardiopulmonary resuscitation (CPR) mask, a CPR valve (with or without a mask), or a CPR resuscitation bag. The split passageway resuscitation training device can allow a simulated rescuer and a simulated victim to use a CPR mask. For instance, the split passageway resuscitation training device can allow the training rescuer to practice exhaling into the mask without the “live” victim having to inhale the rescuer's breaths. The split passageway resuscitation training device also allows the victim to breathe through a different passageway of the device while wearing the mask.Type: ApplicationFiled: January 15, 2021Publication date: July 22, 2021Inventors: George S. Panton, III, Alex Stenzler, Joanne Creighton
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Patent number: 11033692Abstract: A device for adding a flavor and/or cough suppressant component to an inhaler is described. The device includes a housing having an interior chamber, wherein the housing includes at least one air inlet and at least one air outlet connected to the interior chamber, thereby forming an airflow pathway through the interior chamber, and at least one flavoring and/or cough suppressant component positioned within the interior chamber, wherein the housing is attachable to an exterior surface of an inhaler having at least one air inlet, such that the at least one air outlet of the device aligns with the at least one air inlet of the inhaler to form an airflow path through the device and into the inhaler.Type: GrantFiled: April 13, 2016Date of Patent: June 15, 2021Assignee: Philip Morris Products S.A.Inventors: Alex Stenzler, Steve Han, Arthur Slutsky, Steven Ellis, Noe Zamel, Bildad Nyambura