Abstract: Disclosed are bifunctional compounds comprising a GDC-0068 analog that binds AKT isoforms AKT1, 2 and 3, pharmaceutical compositions, and methods for treating diseases or conditions mediated by dysfunctional AKT activity.

Abstract: Methods for treating cancer in a subject by administering a therapeutically effective amount of a pyrimidine synthesis inhibitor and a genotoxic chemotherapeutic agent. In some embodiments, the cancer is triple negative breast cancer.

Abstract: A method of device maintenance, comprising: providing a maintenance network including a user site and a multi-device servicing site that provides maintenance to at least one target device in said user site; selecting, by a user, a degree of access of maintenance functions of said servicing site to at least one of maintenance-related information of said target device and commanding said target device to perform a maintenance-related task; and setting said degree of access.

Abstract: The present invention provides therapeutic and diagnositic methods for neoplasia treatment. The invention also relates to determining the prognosis of a neoplasia or determining a treatment protocal. Further features of the invention are methods for identifying NFAT target genes that promote neoplasia progression.

Abstract: An abstraction unit, comprising a conversion module adapted to translate general instructions, having a format that is independent of a target device model, to specific instructions for each of a plurality of different target device models, said module having at least one programmable and user accessible rule element which defines said translation; and a presentation module adapted to receive responses from a plurality of said target devices, said module having at least one programmable and user accessible rule element which converts said responses into a standardized response format that is independent of the device model that sent the response.

Abstract: A generic software logging package (item 13 or FIG. 1) for using with a user software application (12). The software logging package includes at least one function which stores logging data into at least one logging buffer (17) and at least one macro command (20) which expands into a conditional call to the at least one function, the conditional call including a call statement which transfers to the called function at least one redundant parameter.