Abstract: Automated pipetting systems and methods are disclosed for aspirating and dispensing fluids, particularly biological samples. In one aspect, a liquid dispenser includes a manifold and one or more pipette channels. The manifold includes a vacuum channel, a pressure channel, and a plurality of lanes. Each lane includes an electrical connector, a port to the pressure channel, and a port to the vacuum channel. The pipette channels can be modular. Each pipette channel includes a single dispense head and can be selectively and independently coupled to any one lane of the plurality of lanes. In some aspects, a valve in the pipette channel is in simultaneous fluid communication with a pressure port and a vacuum port of the manifold. The valve selectively diverts gas under pressure and gas under vacuum to the dispense head in response to control signals received through the electrical connector of the manifold.

Abstract: A computer system may receive one or more requests for access to one or more cloud services and may store the one or more requests in a request log. The computer system may receive one or more access rules applicable to cloud service access rights. The computer system may aggregate the one or more requests of the request log to determine access requirements for a container, the container being configured to store one or more applications. The computer system may generate and store container access policies that define access of a container and the one or more cloud services, the container access policies based at least in part on the aggregated one or more requests and the one or more access rules. The computer system may send the container access policies to a request forwarder of a compute instance in a production environment.

Abstract: The technology described herein efficiently determines whether a real inode is shared among views, or owned. In-memory data structures include a view snapshot generation counter that is increased as a snapshot that generates a view is created, and an inode total weight. An in-memory virtual inode cache dataset for a filesystem object associated with the view is instantiated with the value of snapshot generation counter, sharing-related data based on the inode mapping file entry for the object, and an inode access weight. To determine whether the inode is shared (and needs to be split), such as on a write to the object, the in-memory data is evaluated. The real inode is shared if the generation counters are unequal, if the sharing-related data indicates sharing at an intermediate indirect block level, or indicates sharing at the inode level and the inode access weight is less than the inode total weight.

Abstract: A method for determining improved control parameters of a number of wind turbines of a wind park is provided. The method considers the impact of individual turbine manufacturing tolerances on the turbine performance, thereby avoiding under-utilization of those wind turbines. The method includes the steps of: receiving, by an interface, one or more actual manufacturing tolerances of characteristic values for each of the number of wind turbines; determining, by a processing unit, for each of the number of wind turbines a power versus wind speed map which is calculated from a given turbine model with the one or more actual manufacturing tolerances of the respective wind turbines as input parameters; and deriving, by the processing unit, the control parameters for each of the number of wind turbines from their associated power versus wind speed map.

Abstract: The present invention relates to methods of detecting CD200L in a female subject from a secretory phase biological sample. Increased levels of CD200L have been determined to be associated with endometriosis. CD200L is therefore a useful biomarker for the diagnosis of endometriosis and a useful target for therapeutic intervention.

Abstract: A system may use sensor data from a facility to generate tentative values associated with an event, such as the identification of an item removed from a shelf of the facility. A confidence value associated with each of the tentative values may be less than a confidence threshold. In response, inquiry data seeking confirmation of a tentative value from an associate is generated and sent to one or more associates in the facility. Responses from the associates are collected to determine a selection of one of the tentative values. The selected tentative value is designated as output data for the system. Thereafter, the output data and the original sensor data are designated as training data, which can then be used to train or update machine learning systems. Subsequent use of the updated machine learning systems can yield more accurate results.

Abstract: Automated pipetting systems and methods are disclosed for aspirating and dispensing fluids, particularly biological samples. In one aspect, a liquid dispenser includes a manifold and one or more pipette channels. The manifold includes a vacuum channel, a pressure channel, and a plurality of lanes. Each lane includes an electrical connector, a port to the pressure channel, and a port to the vacuum channel. The pipette channels can be modular. Each pipette channel includes a single dispense head and can be selectively and independently coupled to any one lane of the plurality of lanes. In some aspects, a valve in the pipette channel is in simultaneous fluid communication with a pressure port and a vacuum port of the manifold. The valve selectively diverts gas under pressure and gas under vacuum to the dispense head in response to control signals received through the electrical connector of the manifold.

Abstract: The present invention relates to methods of detecting CD200L in a female subject from a secretory phase biological sample. Increased levels of CD200L have been determined to be associated with endometriosis. CD200L is therefore a useful biomarker for the diagnosis of endometriosis and a useful target for therapeutic intervention.

Abstract: This disclosure describes a system for tracking removal or placement of items at inventory locations with a materials handling facility. In some instances, a user may remove an item from an inventory location and the inventory management system may detect that removal and update a user item list associated with the user to include an item identifier representative of the removed item. Likewise, if the user places an item at an inventory location, the inventory management system may detect that placement and update the user item list to remove an item identifier representative of the placed item.

Abstract: An optical element comprising a window formed of synthetic diamond material and an optical surface pattern formed directly in a surface of the synthetic diamond material. The window of synthetic diamond material is in the form of a wedged diamond window with non-parallel major surfaces defining a wedge angle in a range (1) arcminute to 10° and the optical surface pattern is formed directly in one or both of the non-parallel major surfaces. There is also described a laser system comprising the optical element and a laser having a coherence length, wherein the coherence length of the laser is greater than twice a thickness of the wedged diamond window at its thickest point.

Abstract: This disclosure describes a system for tracking removal or placement of items at inventory locations with a materials handling facility. In some instances, a user may remove an item from an inventory location and the inventory management system may detect that removal and update a user item list associated with the user to include an item identifier representative of the removed item. Likewise, if the user places an item at an inventory location, the inventory management system may detect that placement and update the user item list to remove an item identifier representative of the placed item.

Abstract: This disclosure describes techniques for utilizing sensor data to determine the results of events within a system. Upon receiving sensor data indicative of an event, the sensor data is analyzed to determine a result of the event. For instance, a user may identified upon entry to a facility, may pick items from shelves in the facility, and may be identified upon exit. Contents of a virtual shopping cart of the user may be maintained based on analysis of the sensor data as the user picks the items. When a user exits, a payment instrument of the user may be charged for a cost of the items and a receipt may be sent to a device of the user. A state-invariant time, representing a time before which all events have been processed, may be maintained such that no shopping sessions are finalized prior to the state-invariant time to avoid mistaken charges.

Abstract: A bulk data distribution system in which, instead of multiple data consumers contending to access the same data sets from a primary data store, one or more producers capture snapshots (states of the data sets at particular points in time) and upload the snapshots to an intermediate data store for access by snapshot consumers. The snapshot consumers may download the snapshots to generate local versions of the data sets for access by one or more data processing applications or processes. A snapshot producer may periodically generate full snapshots of a data set, and may generate one or more incremental snapshots of the data set between full snapshots. A snapshot consumer may bootstrap a local data set from a full snapshot and one or more incrementals, and may maintain state of the local data set by accessing new snapshots uploaded by the producer.

Abstract: The present invention relates in part to devices, systems, and methods for the production and characterization of engineered tissue constructs. The devices and methods generate decellularized tissue constructs that can be recellularized using donor cells for high-throughput studies of organ physiology, and/or organ pathology. The devices and methods can be used with the systems to mechanically and electrically stimulate the engineered tissue constructs under culture or physiological conditions to detect and assess the presence and degree of any organ pathologies.

Abstract: In one example, an electronic device state may be set based on user activity modes. The electronic device may include a battery; a power adapter; a sensor device; a processor; and memory storing machine-readable instructions to cause the processor to: determine, using sensor device data, which one of a walk mode and a backpack mode the electronic device is in, where the electronic device is in motion during the walk mode, and the electronic device is in motion and is disposed in a bag during the backpack mode; and where the machine-readable instructions set the electronic device to a device ready if the electronic device is in the walk mode, set the electronic device to a low power state to reduce battery power usage if the electronic device is in the backpack mode.

Abstract: Automated pipetting systems and methods are disclosed for aspirating and dispensing fluids, particularly biological samples. In one aspect, a liquid dispenser includes a manifold and one or more pipette channels. The manifold includes a vacuum channel, a pressure channel, and a plurality of lanes. Each lane includes an electrical connector, a port to the pressure channel, and a port to the vacuum channel. The pipette channels can be modular. Each pipette channel includes a single dispense head and can be selectively and independently coupled to any one lane of the plurality of lanes. In some aspects, a valve in the pipette channel is in simultaneous fluid communication with a pressure port and a vacuum port of the manifold. The valve selectively diverts gas under pressure and gas under vacuum to the dispense head in response to control signals received through the electrical connector of the manifold.

Abstract: Automated pipetting systems and methods are disclosed for aspirating and dispensing fluids, particularly biological samples. In one aspect, a liquid dispenser includes a manifold and one or more pipette channels. The manifold includes a vacuum channel, a pressure channel, and a plurality of lanes. Each lane includes an electrical connector, a port to the pressure channel, and a port to the vacuum channel. The pipette channels can be modular. Each pipette channel includes a single dispense head and can be selectively and independently coupled to any one lane of the plurality of lanes. In some aspects, a valve in the pipette channel is in simultaneous fluid communication with a pressure port and a vacuum port of the manifold. The valve selectively diverts gas under pressure and gas under vacuum to the dispense head in response to control signals received through the electrical connector of the manifold.