Abstract: An applicator for a syringe is provided that includes a hub configured to be disposed at least partially within a nozzle of the syringe and defining a fluid passage therethrough, with one or barbs on the hub that frictionally and sealingly engage an interior of the nozzle in a manner minimizing void space associated with waste of deliverable material, and an applicator tip extending distally from the hub. The barb(s) may have varying diameters in order to enable the applicator to be engaged and utilized with syringes having different diameter nozzles. Further the fluid passage through the hub and applicator tip is dimensioned to minimize the volume of material that is retained within the applicator after use, thereby increasing the volume of material that can dispensed from the syringe for use in a procedure or procedures and minimize waste.

Abstract: A hydrodissection material provides a flowable biocompatible material that increases in viscosity in situ to reduce material migration during an ablation procedure. One embodiment provides a material that increases in viscosity at normal body temperatures to permit injection using a standard hypodermic needle.

Abstract: The present invention provides TUP1 polynucleotides, including TUP1 polynucleotides encoding Tup1, and Tup1 polypeptides, from Candida albicans. Disruption of TUP1 function in C. albicans is associated with filamentous formation as well as low infectivity. These TUP1 polynucleotide and Tup1 polypeptide sequences (and anti-Tup1 antibodies derived from Tup1 polypeptides) may be used in methods of detecting C. albicans sequences in a biological sample. Further, the invention provides methods for screening agents which may control C. albicans virulence and compositions comprising these agents. The invention also provides methods of obtaining gene(s) and/or gene product(s) which are involved in a TUP1 pathway, as well as methods of controlling C. albicans virulence by comprising TUP1 function.

Abstract: The present invention provides RBT1 polynucleotides, including RBT1 polynucleotides encoding Rbt1, and Rbt1 polypeptides, from Candida albicans. Expression of the RBT1 gene is upregulated by the inactivation of the TUP1 gene and by environmental conditions that induce filamentous growth. Disruption of TUP1 finction in C. albicans is associated with filament fonnation as well as low infectivity. These RBT1 polynucleotide and Rbtl polypeptide sequences (and anti-Rbt1 antibodies derived from Rbt1 polypeptides) may be used in methods of detecting C. albicans sequences in a biological sample. Further, the invention provides methods for screening agents which may control C. albicans virulence and compositions comprising these agents.

Abstract: A skimmer assembly for use in a well has a shielded float/filter assembly with a hydrophobic/oleophilic filter element, which permits selective passage of lighter than water liquids, such as oil or other hydrocarbons, to the inlet of a pumping assembly. The pumping assembly is provided with two pumps: a lower pump for pumping the lighter than water liquid to the surface of the earth, and an upper pump for pumping water in the well to the surface of the earth. Each pump is operated by a common logic valve, to which compressed air is supplied and which regulates the application of compressed air to the upper side of a diaphragm in each pump. The lower side of the diaphragm is forced upwardly by means of a spring arranged within the pumping volume of the pump housing and a backing plate positioned just below the diaphragm. A bias spring between the backing plate and a centrally located inlet valve function to close the valve from the inlet to the pump.