Abstract: A seaming roll for sealing a container includes a rotation body rotatable on a bolt for sealing the container. The rotation body includes a first basic side and a second basic side different from the first basic side and a bearing. The bolt is arranged on the bearing via the first basic side such that the rotation body can be rotated about the bolt in the circumferential direction of the second basic side when the container is sealed. The seaming roll further includes an exchangeable seaming profile for seaming a container lid with a body of the container and a fastening mechanism. The exchangeable seaming profile is detachably connected to the rotation body via the fastening mechanism.

Abstract: The invention relates to using a graph database in genetic analyses to link mutation data to extrinsic data. Entities such as mutations, patients, samples, alleles, and clinical information are individually represented and stored as nodes and relationships between entities are also individually represented and stored. Each node and relationship can be stored using a fixed-size record and nodes can be flexibly invoked to represent any entity without disrupting the existing data. Systems and methods of the invention may be used for obtaining data representing a mutation in an individual and using a node in a graph database to store a description of the mutation. The node has stored within it a pointer to an adjacent node that provides information about a clinical significance of the variant. The graph database can be queried to provide a report of the clinical significance of the mutation.

Abstract: The invention relates to using a graph database in genetic analyses to link mutation data to extrinsic data. Entities such as mutations, patients, samples, alleles, and clinical information are individually represented and stored as nodes and relationships between entities are also individually represented and stored. Each node and relationship can be stored using a fixed-size record and nodes can be flexibly invoked to represent any entity without disrupting the existing data. Systems and methods of the invention may be used for obtaining data representing a mutation in an individual and using a node in a graph database to store a description of the mutation. The node has stored within it a pointer to an adjacent node that provides information about a clinical significance of the variant. The graph database can be queried to provide a report of the clinical significance of the mutation.