Abstract: Provided are methods for the treatment of spinal muscular atrophy (SMA) in a fetal subject in need thereof comprising administering an amount of risdiplam to a carrier of the fetal subject. Administering the amount of risdiplam to the carrier of the fetal subject results in transplacental delivery to the fetal subject, resulting in an increase in SMN protein production.

Abstract: Methods, computer systems, and apparatus, including computer programs encoded on computer storage media, for predicting an exchange-correlation energy of an atomic system. The system obtains respective electron-orbital features of the atomic system at each of a plurality of grid points; generates, for each of the plurality of grid points, a respective input feature vector for the electron-orbital features at the grid point; and processes the respective input feature vectors for the plurality of grid points using a neural network to generate a predicted exchange-correlation energy of the atomic system.

Abstract: Examples include a device including a fluid lens having a membrane, a substrate, and a fluid at least partially enclosed between the membrane and the substrate. The membrane may have a spatial variation in at least one membrane parameter along a particular direction, that may compensate for gravity sag in the membrane of the fluid lens when the device is worn by a user. Examples also include related methods and systems.

Abstract: Examples include a device including a fluid lens having a membrane (that may be in elastic tension), a substrate, a fluid at least partially enclosed between the membrane and the substrate, and a support structure configured to provide a guide path for an edge portion of the membrane, such as a membrane attachment at a periphery of the membrane. The guide path may be configured to greatly reduce (or substantially eliminate) changes in the elastic energy of the membrane as the membrane profile is adjusted. The guide path may be configured so that the elastic force exerted by the membrane is generally normal to the guide path for each location on the guide path. Adjustment of the membrane profile may include applying an actuation force that is normal to the elastic force exerted by the membrane. Various other methods and apparatus are also disclosed.

Abstract: The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to ATXN3 pre-mRNA sequences, which are capable of inhibiting the expression of ATXN3 protein. Inhibition of ATXN3 expression is beneficial for the treatment of spinocerebellar ataxia.

Abstract: The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to ATXN3 pre-mRNA sequences, which are capable of inhibiting the expression of ATXN3 protein.

Abstract: An example device may include a fluid lens having a membrane assembly including a membrane and one or more membrane attachments, a substrate, a fluid located within an enclosure formed at least in part by the membrane and the substrate, and a support structure, attached to the substrate, including an actuation guide. The device may include an actuator mechanically coupled to the actuation guide and configured to change an orientation of the actuation guide relative to another device component, such as a substrate or frame. An example actuation guide may engage with the membrane attachment, and the movement of the membrane attachment along the actuation guide in response to the change in the orientation of the actuation guide may adjust an optical property, such as a focal length, of the fluid lens.

Abstract: The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to ATXN3 pre-mRNA sequences, which are capable of inhibiting the expression of ATXN3 protein. Inhibition of ATXN3 expression is beneficial for the treatment of spinocerebellar ataxia.

Abstract: The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to ATXN3 pre-mRNA sequences, which are capable of inhibiting the expression of ATXN3 protein. Inhibition of ATXN3 expression is beneficial for the treatment of spinocerebellar ataxia.

Abstract: In some embodiments, a method sends a first instance of a media presentation description including first status information to a client. The first status information identifies a break from a stream of a media presentation for insertion of supplemental content. The method receives a request for a second instance of the media presentation description. The request includes information from the first status information that reverted the client back to the stream of the media presentation after insertion of the supplemental content. Then, the method sends the second instance of the media presentation description based on receiving the request from the client including the information from the first status information.

Abstract: Examples include a device including a fluid lens having a membrane (that may be in elastic tension), a substrate, a fluid at least partially enclosed between the membrane and the substrate, and a support structure configured to provide a guide path for an edge portion of the membrane, such as a membrane attachment at a periphery of the membrane. The guide path may be configured to greatly reduce (or substantially eliminate) changes in the elastic energy of the membrane as the membrane profile is adjusted. The guide path may be configured so that the elastic force exerted by the membrane is generally normal to the guide path for each location on the guide path. Adjustment of the membrane profile may include applying an actuation force that is normal to the elastic force exerted by the membrane. Various other methods and apparatus are also disclosed.

Abstract: The present invention relates to antisense LNA oligonucleotides (oligomers) complementary to ATXN3 pre-mRNA sequences, which are capable of inhibiting the expression of ATXN3 protein. Inhibition of ATXN3 expression is beneficial for the treatment of spinocerebellar ataxia.

Abstract: Examples include a device including a fluid lens having a membrane (that may be in elastic tension), a substrate, a fluid at least partially enclosed between the membrane and the substrate, and a support structure configured to provide a guide path for an edge portion of the membrane, such as a membrane attachment at a periphery of the membrane. The guide path may be configured to greatly reduce (or substantially eliminate) changes in the elastic energy of the membrane as the membrane profile is adjusted. The guide path may be configured so that the elastic force exerted by the membrane is generally normal to the guide path for each location on the guide path. Adjustment of the membrane profile may include applying an actuation force that is normal to the elastic force exerted by the membrane. Various other methods and apparatus are also disclosed.

Abstract: In some embodiments, a method sends a first instance of a media presentation description including first status information to a client. The first status information identifies a break from a stream of a media presentation for insertion of supplemental content. The method receives a request for a second instance of the media presentation description. The request includes information from the first status information that reverted the client back to the stream of the media presentation after insertion of the supplemental content. Then, the method sends the second instance of the media presentation description based on receiving the request from the client including the information from the first status information.

Abstract: In some embodiments, a method receives a request from a client including first status information. The status information was included in a first instance of a media presentation description for a first set of segments of a stream of a media presentation and identified a break from the stream of the media presentation for insertion of supplemental content. The method uses the first status information to identify supplemental content for the client. A second instance of the media presentation description is sent for at least a portion of the supplemental content. The second instance of the media presentation description includes second status information that reverts the client back to the stream of the media presentation after insertion of the supplemental content.

Abstract: The present invention relates to a redox fuel cell comprising an anode and a cathode separated by an ion selective polymer electrolyte membrane; means for supplying a fuel to the anode region of the cell; means for supplying an oxidant to the cathode region of the cell; means for providing an electrical circuit between the anode and the cathode; a non-volatile catholyte solution flowing in fluid communication with the cathode, the catholyte solution comprising a polyoxometallate redox couple being at least partially reduced at the cathode in operation of the cell, and at least partially re-generated by reaction with the oxidant in a regeneration zone after such reduction at the cathode, the catholyte solution further comprising one or more vanadium species that result from the speciation of the polyoxometallate at an elevated temperature and/or pressure, wherein the polyoxometallate is represented by the formula: Xa[ZbMcOd] wherein X is selected from hydrogen, alkali metals, alkaline earth metals, ammonium,

Abstract: In some embodiments, a method receives a request from a client including first status information. The status information was included in a first instance of a media presentation description for a first set of segments of a stream of a media presentation and identified a break from the stream of the media presentation for insertion of supplemental content. The method uses the first status information to identify supplemental content for the client. A second instance of the media presentation description is sent for at least a portion of the supplemental content. The second instance of the media presentation description includes second status information that reverts the client back to the stream of the media presentation after insertion of the supplemental content.

Abstract: The present invention relates to a redox fuel cell comprising an anode and a cathode separated by an ion selective polymer electrolyte membrane; means for supplying a fuel to the anode region of the cell; means for supplying an oxidant to the cathode region of the cell; means for providing an electrical circuit between the anode and the cathode; a non-volatile catholyte solution flowing in fluid communication with the cathode, the catholyte solution comprising a polyoxometallate redox couple being at least partially reduced at the cathode in operation of the cell, and at least partially re-generated by reaction with the oxidant in a regeneration zone after such reduction at the cathode, the catholyte solution further comprising one or more vanadium species that result from the speciation of the polyoxometallate at an elevated temperature and/or pressure, wherein the polyoxometallate is represented by the formula: Xa[ZbMcOd] wherein X is selected from hydrogen, alkali metals, alkaline earth metals, ammonium

Abstract: A redox fuel cell comprising an anode and a cathode separated by an ion selective polymer electrolyte membrane; means for supplying a fuel to the anode region of the cell; means for supplying an oxidant to the cathode region of the cell; means for providing an electrical circuit between the anode and the cathode; a non-volatile catholyte solution flowing fluid communication with the cathode, the catholyte solution comprising a polyoxometallate redox couple being at least partially reduced at the cathode in operation of the cell, and at least partially re-generated by reaction with the oxidant after such reduction at the cathode, wherein the polyoxometallate is represented by the formula: Xa[ZbMcOd] Wherein X is selected from hydrogen, alkali metals, alkaline earth metals, ammonium and combinations of two or more thereof; Z is selected from B, P, S, As, Si, Ge, Ni, Rh, Sn, Al, Cu, I, Br, F, Fe, Co, Cr, Zn, H2, Te, Mn and Se and combinations of two or more thereof; M comprises W and optionally one or more of