Abstract: A device for producing microscopic arrays of molecules is provided, the device comprising a plurality of inverted cavities containing solutions, a substrate adapted to be received by the cavities for extracting the solutions, a substrate for depositing the extracted solutions onto a location on a matrix; and a quality control monitoring system for verifying that the solutions are deposited onto the location on the matrix. A process for producing an array of molecules also is provided, the process comprising providing a plurality of inverted solution cavities, wherein each cavity contains a solution; extracting each solution from its respective inverted cavity; loading each solution at a predetermined position in an array; and verifying that each solution is loaded onto its respective position in the array.

Abstract: A biochip scanner device used to detect and acquire fluorescence signal data from biological microchips or biochips and method of use are provided. The biochip scanner device includes a laser for emitting a laser beam. A modulator, such as an optical chopper modulates the laser beam. A scanning head receives the modulated laser beam and a scanning mechanics coupled to the scanning head moves the scanning head relative to the biochip. An optical fiber delivers the modulated laser beam to the scanning head. The scanning head collects the fluorescence light from the biochip, launches it into the same optical fiber, which delivers the fluorescence into a photodetector, such as a photodiode. The biochip scanner device is used in a row scanning method to scan selected rows of the biochip with the laser beam size matching the size of the immobilization site.